Recombinant Mouse Macrophage-stimulating protein receptor (Mst1r), partial

1. RON has a role in cancer-induced bone destruction and osteoporosis PMID: 28123075
2. this study shows that Ron is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1 PMID: 27233965
3. Report Ron receptor-dependent gene regulation of inflammatory/anti-inflammatory gene expression in Kupffer cells during endotoxemia. PMID: 24919612
4. Ron knockdown further sensitized breast cancer cells to the growth inhibitory effects of vitamin D3, while constitutive activation of beta-catenin reverted the effects of vitamin D3. PMID: 26008979
5. Studies demonstrate that DEK overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt/beta-catenin signaling. PMID: 24954505
6. A previously unknown function for the Ron receptor in mediating High Fat Diet-induced obesity and metabolic dysregulation. PMID: 25648832
7. important functional roles for Ron in inflammatory bowel diseases by regulating healing of the colonic epithelium and by controlling cytokine secretion PMID: 24742989
8. DC-STAMP, Siglec-15, Tspan7 and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro. PMID: 23945674
9. Stem cell-derived tyrosine kinase plays a role in regulating macrophage recruitment and activation in the liver following acetaminophen administration and in hepatotoxicity. PMID: 22575169
10. studies show a critical role for the Ron receptor in the tumor microenvironment, whereby Ron loss in tumor-associated macrophages inhibits prostate cancer cell growth, at least in part, by derepressing the activity of CD8(+) T cells PMID: 23328584
11. Identify a novel signaling mechanism by which the Ron receptor regulates acute liver failure progression. PMID: 22893465
12. HGF/c-Met plays a crucial role in host and donor cells of the liver for the cursiv selection of transplanted hepatocytes. PMID: 22287599
13. Data suggest an important role for beta-catenin downstream of Ron receptor signaling during the development of mammary tumorigenesis. PMID: 22474186
14. loss of ERalpha on a Ron overexpressing background in mice leads to the development of breast tumors PMID: 22226043
15. The Ron receptor promotes prostate tumor growth in the TRAMP mouse model. PMID: 21625214
16. Ron overexpression led to the development of prostate intraepithelial neoplasia (mPIN) with local invasion and was associated with increases in prostate cell proliferation and decreases in cell death. PMID: 22004727
17. we show that genetic ablation of beta-catenin in Ron-expressing breast cancer cells decreases cellular proliferation in vitro, as well as mammary tumor growth and metastasis PMID: 21423209
18. Inhibition of TLR4-induced IkappaB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein. PMID: 21078906
19. Ron impacts the progression of inflammatory immune responses in vivo and further support a role for the Ron receptor and its various forms in liver pathophysiology. PMID: 17008558
20. Ron overexpression on a Chk2*1100 deletion background accelerates the development of mammary tumors. PMID: 20434834
21. MSP/STK signaling plays a role in up-regulating macrophage and endothelial cell anti-inflammatory activity during hepatic inflammatory responses PMID: 20453108
22. Results indicate that Ron plays a critical role in regulation of alveolar macrophage signaling and validates this receptor as a target in TNFalpha-mediated pulmonary pathologies. PMID: 19487969
23. data demonstrate that the interaction of gp55 with Sf-Stk is dependent on cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk PMID: 20016000
24. Findings indicate that RON signaling mediates cell survival and in vivo resistance to gemcitabine in pancreatic cancer. PMID: 20103639
25. Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein induces arginase activity in peritoneal macrophages. PMID: 11777982
26. demonstrate that the control of erythroid blast-forming unit cycling is encoded by a gene linked to, but distinct from, Fv2, and suggest that this gene is the dual-specific protein phosphatase Cdc25A PMID: 12411323
27. Data show that Ron mRNA is expressed by nerve growth factor-dependent sensory and sympathetic neurons and that these neurons survive and grow with macrophage stimulating protein (MSP) at different stages of development. PMID: 12538524
28. activation of the Ron receptor by may aid in implantation by way of trophoblast function and viability PMID: 12606483
29. sf-Stk, activated by either point mutation or interaction with SFFV gp55, is sufficient to induce Epo-independent erythroid colonies from both Fv-2-susceptible and -resistant mice but is unable to cause erythroleukemia in Fv-2-resistant mice. PMID: 15078939
30. Ron receptor can interact with each of the three members of class B Plexins and control tumor invasive growth. PMID: 15184888
31. Loss of Ron receptor signaling significantly reduced the percent of papillomas that underwent malignant conversion and the number of mice developing other malignant tumor types (Ron receptor) PMID: 15531916
32. the activated beta-catenin cascade is one of the pathways involved in tumorigenic activities mediated by the oncogenic RON variant PMID: 15878878
33. The proto-oncogene, c-Cbl, which modulates ubiquitylation of RON, was increased in glia in both multiple sclerosis brains and experimental autoimmune encephalomyelitis spinal cords PMID: 15929040
34. the ligand-dependent and -independent activity of mRon can be uncoupled through the alteration of selective sets of tyrosines PMID: 16103119
35. altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity PMID: 16166096
36. Results suggest that Mst1r signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. PMID: 16166746
37. Ron is ubiquitylated also by the U-box E3 ligase C-terminal Hsc70-interacting protein (CHIP), recruited via chaperone intermediates Hsp90 and Hsc70 PMID: 16740632
38. Data demonstrate that Stat3 is required for the erythropoietin-independent growth of Friend virus-infected cells and that the activation of Stat3 by Sf-Stk is mediated by a novel Stat3 binding site in Gab2. PMID: 17353274
39. Expression of a Cbl-Grb2 chimera rescued impaired cMet endocytosis in cells depleted of endogenous Grb2 PMID: 17449471
40. RON receptor signaling may contribute to pancreatic carcinogenesis PMID: 17616662
41. Stk and its downstream effectors are critical to the Friend spleen focus-forming virus transformation in fibroblasts. PMID: 17959667
42. RON receptor regulates both the production of and response to IFN-gamma, resulting in enhanced susceptibility to endotoxin challenge. PMID: 18684919
43. Microarray analysis of pubertal RonTK-/- glands revealed 393 genes temporally impacted by Ron expression with significant changes observed in signaling networks regulating development, morphogenesis, differentiation, cell motility, and adhesion. In PMID: 19576199

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KEGG: mmu:19882

STRING: 10090.ENSMUSP00000035203

UniGene: Mm.3901