Recombinant Mouse Metabotropic glutamate receptor 5 (Grm5), partial

1. Describe a complete knockout mouse model of the autism-associated Shank3 gene, with a deletion of exons 4-22 (Deltae4-22). Both mGluR5-Homer scaffolds and mGluR5-mediated signalling are selectively altered in striatal neurons. These changes are associated with perturbed function at striatal synapses, abnormal brain morphology, aberrant structural connectivity and autism spectrum disorder-like behaviour. PMID: 27161151
2. Study identified an unexpected age-linked recovery of synaptic gain function in Fragile X syndrome (FXS) model mice medial prefrontal cortex. Stimulus evoked long-term depression mediated by endocannabinoids, absent in early adulthood (2-month-old), is recovered with senescence (at 1-year-old); recovery depends on the engagement of alternative mGlu5 coupled mechanisms. PMID: 27797833
3. Study shows that blocking of metabotropic glutamate type 5 receptor (mGlu5) reduced the dysregulation of glutamate transmission and improved motor coordination in the Grm1crv4 mouse model of cerebellar ataxia SCAR13. PMID: 28982591
4. The authors here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5) contribute to the molecular machinery governing sleep-wake homeostasis. PMID: 28980941
5. mGluR5 was significantly more mobile at synapses in hippocampal Fmr1 KO neurons, causing an increased synaptic surface co-clustering of mGluR5 and NMDAR. PMID: 29062097
6. Results support positive allosteric modulation of mGlu5, particularly with VU0409551, as a viable mechanism to reverse the deficits in NMDA receptor function, synaptic plasticity, and memory that are known to be impaired in schizophrenia. PMID: 26741285
7. Collectively, these results indicate that selective antagonism of glutamate and mGluR5 has a potentially beneficial effect in both liver cancer and Parkinson's disease, and thus may provide more understanding for the clinical investigation and further an additional therapeutic target for these two diseases. PMID: 28455267
8. beta-arrestin2-biased negative modulators of mGlu5 offer significant advantages over first-generation inhibitors for the treatment of fragile X and related disorders. PMID: 28329674
9. mGluR5 and CB1 act in concert to activate neuroprotective cell signaling pathways and promote neuronal survival. PMID: 27543109
10. This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 from hippocampal tissue. PMID: 27392515
11. Here, we show in a mouse model of Rett syndrome (Mecp2 KO) that metabotropic glutamate receptor 5 (mGluR5)- and protein-synthesis-dependent synaptic plasticity are abnormal in the hippocampus. PMID: 27881780
12. In a mouse model mimicking n-3 PUFA dietary deficiency during adolescence and adulthood, we found strong increases in anxiety and anhedonia which lead to decreases in specific cognitive functions in adulthood. We found that endocannabinoid/mGlu5-mediated LTD and NMDAR-dependent LTP were lacking in adult n-3-deficient mice. PMID: 28630250
13. findings demonstrate a causal role for increased mGluR5 signaling in driving striatal output abnormalities and behaviors with relevance to Obsessive Compulsive Disorder and show the tractability of acute mGluR5 inhibition to remedy circuit and behavioral abnormalities. PMID: 27436084
14. our novel mGlu5 PAM improves Rett syndrome (RS)phenotypes and synaptic plasticity defects without evoking the overt adverse effects commonly associated with potentiation of mGlu5 signaling (i.e. seizures), or affecting cardiorespiratory defects in RS model mice. These findings provide strong support for the continued development of mGlu5 PAMs as potential therapeutic agents for use in RS, and, more broadly, for utility in PMID: 26936821
15. This study used genetic mGluR5 mosaic animals to elucidate mGluR5s' cell-autonomous influences on the anatomical and functional development of cortical glutamatergic neurons. PMID: 27559164
16. There was a general decline in mGluR5 brain expression and elevated levels of mGluR5 in older amyloid precursor protein transgenic mice compared to wild-type. PMID: 27743932
17. Here we identify mGluR1 and mGluR5 as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN. Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain. PMID: 27466334
18. The present results showed that ER knockout alpha and beta male mice had lower striatal mGlu5 receptor binding and protein measured by Western blot. PMID: 26873133
19. These results suggest that PrP(C)-mGluR5 form a functional response unit by which multiple ligands can trigger signaling. We propose that trafficking of PrP(C)-mGluR5 may modulate signaling intensity by different PrP(C) ligands. PMID: 27563063
20. GluD1 interacts with mGlu5, and loss of GluD1 impairs normal mGlu5 signaling potentially by dysregulating coupling to its effector. PMID: 27231330
21. This study further distinguishes two separate Abetao-dependent signaling cascades, one dependent on extracellular Ca(2+) and Fyn kinase activation and the other dependent on the release of Ca(2+) from intracellular stores. Thus, Abetao triggers multiple distinct PrP(C)-mGluR5-dependent events implicated in neurodegeneration and dementia. PMID: 27325698
22. mGluR5 may mediate amyloid beta synaptotoxicity and it is a novel therapeutic targets for AD and other cognitive syndromes. PMID: 27103515
23. Dysregulation of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling pathway, accompanied with a downregulation of GABA(A) receptor beta3 subunit expression, may contribute to the 'autistic-like' features knockout mice. PMID: 26559723
24. Our findings suggest a fundamental role for mGluR5 in the development of Pv(+) neurons and show that alterations in this system can produce broad-spectrum alterations in brain network activity PMID: 26260494
25. This work provides strong evidence that Homer-mGlu5 binding contributes to symptoms associated with neurodevelopmental disorders PMID: 26888925
26. This study identify highly specialized roles of lateral septal mGluR5 and Oxtr in the the regulation of discrete social behaviors, and suggest that deficits in social interactions. PMID: 25824423
27. Results offer the first evidence that changes in the striatal expression of mGlu4 and mGlu5 receptors occur in acute models of parkinsonisms PMID: 25747602
28. We show for the first time that knockdown of mGlu5 in the dorsal hippocampus is sufficient to impair spatial learning in Morris Water Maze PMID: 25957750
29. The results of this study demonstrated an important role for mGlu5 in environmental modulation of schizophrenia-related behavioral impairments. PMID: 25666312
30. chronic postnatal down-regulation of mGluR5 signaling produces coordinated impairments in both NMDAR-dependent LTD in vitro and ocular dominance plasticity in vivo. PMID: 26417096
31. mGluR5 blockage elicits distinct outcomes in terms of locomotor activity and motor coordination depending on the brain region injected with mGluR5 antagonist. PMID: 25885370
32. Results provide compelling evidence for the involvement of the Homer1/mGluR5 complex in the emergence and regulation of stress-induced behavioral and neuroendocrine phenotypes PMID: 25409593
33. activating mGlu5R increases the synaptic residency time of Ubc9 via a Galphaq/PLC/Ca(2+)/PKC cascade. PMID: 25311713
34. mGluR5 acting through TRPC3 is of central importance in radial glial-mediated neuronal guidance. PMID: 25347706
35. Genetic and pharmacological reductions of mGluR5 function led to a partial rescue of the social behavior deficit in Fmr1 knockout mice PMID: 25562659
36. Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity PMID: 25297838
37. mGluR5 is necessary for synapse elimination to stimulate dendritic translation of the MEF2 target gene Arc/Arg3.1. PMID: 24857654
38. Targeting the putative MOR-mGluR5 heteromer is far superior to univalent interaction with receptors in reducing tumor-induced nociception. PMID: 25239072
39. A serine residue 870 (S870) in mGluR5, was identified as a direct substrate for protein kinase A. PMID: 25639954
40. findings suggest that changes in astrocyte mGlu5 receptors may be part of an adaptive response to the progressive nature of Alzheimer's disease PMID: 19401173
41. Conditional ablation of mGluR5 in CA1 pyramidal neurons resulted in the inability of low-frequency trains of afferent activation to synapses. PMID: 25505329
42. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. PMID: 24282028
43. The mGlu5 receptor regulates the extinction of cocaine-driven behaviors. PMID: 24576814
44. Amyloid beta (Abeta) activation of mGluR5 appears to initiate a positive feedback loop resulting in increased Abeta formation and Alzheimer's disease pathology. PMID: 24886239
45. vulnerability of hippocampal neurons to alpha-syn and Abeta might be mediated via mGluR5 PMID: 24885390
46. These data indicate that Homer1c-mGluR5 interactions are necessary for mGluR-dependent long-term potentiation PMID: 24167026
47. beta-N-methylamino-l-alanine leads to tau pathology by inhibiting PP2A through the activation of mGluR5, the consequent release of PP2Ac from the mGluR5-PP2A complex, and its phosphorylation at Tyr(307) by Src PMID: 24395787
48. The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. PMID: 23861896
49. FMRP positively regulates translational expression of mGluR5 in astroglial cells, and FMRP-dependent down-regulation of mGluR5 underlies GLT1 dysregulation in fmr1(-/-) astrocytes PMID: 23396537
50. This study demonistrated that Expression of CRFR1 and Glu5R mRNA in different brain areas following repeated testing in mice that differ in habituation behaviour. PMID: 23458743

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KEGG: mmu:108071

STRING: 10090.ENSMUSP00000129181

UniGene: Mm.235018