Recombinant Mouse Metallothionein-1 (Mt1)

1. Cardiac overexpression of either Nrf2 or metallothionein offered cardioprotection from Intermittent hypoxia-induced cardiomyopathy via complicated PI3K/Akt/GSK3B/Fyn signaling. PMID: 28778483
2. high fat diet (HFD) and zinc deficiency synergistically induce obesity-related cardiac hypertrophy (ORCH), by increasing oxidative stress-mediated activation of BCL10/CARD9/p38 MAPK signalling. Zinc supplement ameliorates ORCH through activation of metallothionein to repress oxidative stress-activated BCL10 expression and p38 MAPK activation. PMID: 28158919
3. these results demonstrate that MT1 plays a role in CD4+ T cell activation by transducing reactive oxygen species signals into an increased [Zn2+]i that subsequently affects downstream effector function PMID: 27251638
4. blockade of metallothioneins 1 and 2 constitutes a promising approach for the treatment of conditions which result in muscle atrophy. PMID: 27956698
5. Cardioprotective effects of MT1/2 seem to be exerted via modulation of contractile elements, antioxidative enzymes, inflammatory response, and myocardial remodeling. PMID: 27403038
6. MT-1(/2) protein levels were dramatically increased by Mt1 overexpression throughout the cortex (Cx), which showed a prominent caudal-rostral gradient, and the hippocampus (HC). PMID: 28134760
7. These results suggested that both melatonin and MT1 are involved in the downstream reaction of hCG (LH) and they play important roles in luteinization. PMID: 27177022
8. Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint PMID: 26267326
9. MT overexpression protected beta-cells from acute STZ-induced ROS damages at young age, whereas it impaired insulin secretion and promoted the development of diabetes in adult C57BL/6J mice PMID: 26335571
10. results showed that PQ treatments led to increased MT expression in several organs (liver, kidneys, testes) and in splenocytes, caused a reduction of both free zinc ions in sera and in free intracellular zinc PMID: 25496228
11. Enhanced senescence due to absence of metallothionein genes may shorten lifespan. PMID: 25871729
12. MT1/2 deficiency aggravated depleted uruanium-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression. PMID: 26148447
13. Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent. PMID: 24819347
14. The molecular mechanism underlying enhanced physiological function of Bmi1 depends on the injury context and it is mediated by metallothionein 1 (MT1)-driven modulation of resistance to oxidative stress in the satellite cell population. PMID: 25452464
15. Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure PMID: 25485709
16. zinc-stimulated changes in glucose metabolism mediated by Akt were actually found to be metallothionein dependent, but not Akt2 dependent PMID: 24296248
17. Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1. PMID: 24163136
18. It si an antioxidant pathway gene. PMID: 24467545
19. the metal binding abilities of mouse MT2 (mMT2) with divalent (Zn(II) and Cd(II)) and monovalent (Cu(I)) ions were analyzed and compared to those of the mouse MT1 (mMT1) isoform. PMID: 23925449
20. Metallothionein significantly attenuates tunicamycin-induced cardiac contractile dysfunction, intracellular calcium homeostasis, endoplasmic reticulum stress, oxidative stress, and the induction of autophagy. PMID: 24440343
21. The results of this study suggest that metallothioneins may play a key role in protecting the kidney against high glucose-induced ROS and subsequent inflammation in diabetic nephropathy. PMID: 24154695
22. these results demonstrate that MT-I/II knockout mice are more vulnerable to cadmium-induced fetal growth retardation. PMID: 23880315
23. These data indicate that metallothioneins play an important role in the prevention of colonic mucosal inflammation in a mouse model of dextran sulfate sodium-induced colitis. PMID: 23467591
24. Hypothermia is a potent inducer of metallothionein gene transcription in brain endothelial cells and is protective against cell hypoxia. PMID: 23374901
25. Metallothionein 1 h tumour suppressor activity in prostate cancer is mediated by euchromatin methyltransferase 1. PMID: 23355073
26. Metallothioneins act as negative regulators for IL-27-induced Tr1 cells. PMID: 23630250
27. These results suggest that MT prevention of diabetes-induced pathological changes in cardiac tissues is most likely mediated by suppression of SCOT nitration at Trp(374). PMID: 23423173
28. Metallothionein protects against cold exposure-induced cardiac anomalies possibly through attenuation of cardiac autophagy. PMID: 23132296
29. MT1 + 2 effectively alters the amyloid cascade, survival, body weight, and behavior in a complex manner PMID: 22766972
30. Down-regulation of MT1 and MT2 after electromagnetic fields in mouse testis might be followed by some consequences that result in infertility. PMID: 22395140
31. in the present study, we demonstrated that MT-enhanced HIF-1alpha activity is likely through a mechanism of protein nuclear translocation. These results suggest that MT induces HIF-1alpha expression, leading to increased HK-II in the diabetic heart. PMID: 22523246
32. analysis of the influence of a zinc-enriched environment on survival of metallothionein-1 transgenic mice PMID: 22533418
33. MT-I/II is up-regulated in the liver after brain injury and modulates the amount of zinc that is sequestered to the liver. PMID: 22363575
34. the absence of MT1 and MT2 has no unfavorable effect on ischemic brain injury PMID: 21913972
35. Data suggest that metallothionein (MT)-I/II(-/-) mice have altered immune function and provide a new hypothesis that this alteration is partly responsible for the differences observed in MT-I/II(-/-) mice after brain injury relative to wild type mice. PMID: 22152221
36. MT-I/II may play a key role in IDC proliferation, but is not a useful prognostic factor of this disease PMID: 21868554
37. The study proved that the expression of mice metallothionein in E. coli is suitable for the removal of the heavy metal ions studied from aqueous solutions. PMID: 21866758
38. These data suggest that MT1-MMP directly cleaves Dll1 on bone marrow stromal cells to negatively regulate Notch signalling to specifically maintain normal B-cell development in bone marrow. PMID: 21572390
39. data show that increasing dietary Zn has little effect on disaccharidases activity in metallothionein wild-type mice; presence of MT may enhance morphological and functional development of the gut PMID: 21253395
40. The inhibitory effects of Cr(VI) on MT-I transcription may be due to its effects on the HAT-independent transactivation ability. PMID: 21467744
41. Data show that disruption of nucleosome structure at the MT-I promoter is mediated by zinc-responsive recruitment of an active MTF-1-coactivator complex. PMID: 21035574
42. Knockdown of metallothionein 1 does not affect atrophy or oxidant activity in skeletal myotubes subject to serum reduction. PMID: 20798270
43. Induction of metallothionein-I and -II occurs in the retinitis pigmentosa models studied and correlates with glial activation PMID: 20357188
44. preventive role against high-fat diet-induced obesity by regulating adipocyte enlargement and leptin signaling PMID: 20219986
45. MT-l/II null cardiomyocytes were more sensitive to butenolide-induced cytotoxicity than wild-type cardiomyocytes PMID: 20144643
46. The present results demonstrate that despite the MT-1 domains are chemically independent, they show some cross-talk biologically, and that motifs present in the -domain are essential not only for the biological functions' PMID: 20127815
47. The solution structures of Cd(3)-thiolate cluster containing beta-domain of mouse beta-MT-1 and rat beta-MT-2 show high structural similarities, but widely differing structure dynamics. PMID: 19609577
48. Metallothionein (MT) plays an important role in collateral flow recovery and angiogenesis, mediated in part by the effects of MT on the functionality of 3 cell types: endothelial cells, smooth muscle cells, and macrophages. PMID: 20056912
49. These data favor a beneficial effect of MT in the management of cardiac dysfunction in sepsis. PMID: 19914257
50. MT prevents both diabetes- and angiotensin II-induced cardiac endoplasmic reticulum associated cell death. PMID: 19583814

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KEGG: mmu:17748

STRING: 10090.ENSMUSP00000034215

UniGene: Mm.192991