Recombinant Mouse Mitogen-activated protein kinase kinase kinase 12 (Map3k12), partial

1. These findings demonstrate that pathological activation of DLK is a conserved mechanism that regulates neurodegeneration. PMID: 28814543
2. These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration. PMID: 28440222
3. Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function. PMID: 27468987
4. LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury. PMID: 28641113
5. the prevention of the nuclear localization of DLK as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus PMID: 26776303
6. Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK does not appear to have a critical function in axonal degeneration; function appears restricted to soma PMID: 24878510
7. This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates PMID: 25100604
8. DLK-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures. PMID: 24166713
9. Abundance of DLK in turn controlled the levels of downstream JNK signaling and apoptosis. PMID: 23979718
10. DLK is required for RGC JNK activation and cell death in a rodent model of optic neuropathy PMID: 23431148
11. The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK is an essential upstream mediator of both of these divergent outcomes in the same cell type. PMID: 23431164
12. These data demonstrate that DLK enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program. PMID: 22726832
13. The mixed lineage kinase dual leucine zipper kinase (DLK) selectively regulates the JNK-based stress response pathway to mediate axon degeneration and neuronal apoptosis without influencing other aspects of JNK signaling. PMID: 21893599
14. ZPK/DLK plays a critical role in naturally occurring programmed cell death of motoneurons. PMID: 21593306
15. This study indicated that the DLK-JNK pathway facilitates axon formation in neocortical neurons via stage-specific regulation of microtubule stability. PMID: 21525288
16. Hepatic progenitors from DLK+ hepatocytes were maintained in long-term culture. PMID: 15572411
17. This protein kinase is tightly associated with the microtubules of neurond in the embryonic nervous system. PMID: 15749080
18. Hsp70 contributes to the regulation of activated DLK by promoting its CHIP-dependent proteasomal degradation PMID: 16931512
19. These data suggest that DLK plays a significant role in the coordinated regulation of radial migration and axon projection by modulating JNK activity. PMID: 17108173
20. Activation of Map3k12 and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A is reported. PMID: 18042735
21. Src-dependent tyrosine phosphorylation of endogenous DLK may be important for regulation of its activity. DLK may have a role in PDGF signaling. PMID: 19146952
22. These results indicate that ZPK/DLK is involved in regenerative responses of mammalian dorsal root ganglion neurons to axonal injury through activation of c-JUN. PMID: 19358824

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KEGG: mmu:26404

STRING: 10090.ENSMUSP00000023812

UniGene: Mm.172897