Recombinant Mouse Myogenic factor 5 (Myf5)

1. Novel RNA-binding activity of MYF5 enhances Ccnd1 mRNA translation during myogenesis. PMID: 26819411
2. Transcription of the skeletal muscle program is achieved by the expression of MyoD, which binds to the same sites as Myf5, indicating that each factor regulates distinct steps in gene initiation and transcription at a shared set of binding sites PMID: 26906734
3. The Myf5- and Myogenin-deficient mice showed a partial or complete, respectively, loss of TMC in an otherwise regularly structured thymus. PMID: 26708556
4. Elimination of Myf5(Cre)-DTA cells on a Myod null background did not result in the total absence of skeletal muscles PMID: 25490270
5. A muscle-specific regulatory element of p57(kip2) directly activated by muscle regulatory factors in myoblasts but repressed by the Notch targets Hes1/Hey1 in progenitor cells, is identified. PMID: 25005473
6. lineage tracing based on multiple reporter lines has demonstrated that regardless of common ancestral expression of Myf5, there is a clear distinction between periocular myogenic and non-myogenic cell lineages PMID: 23969310
7. The results demonstrate the heterogeneity and functional differences of the Myf5- and non-Myf5-lineage cells in the white adipose tissue. PMID: 23740968
8. Adult satellite cells derive from progenitors that first express the myogenic determination gene Myf5 during fetal stages of myogenesis. PMID: 23639729
9. Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer PMID: 23384562
10. The observations provide a mechanism linking Myf5 levels to muscle stem cell heterogeneity and fate by exposing two distinct and opposing phenotypes associated with Myf5 haploinsufficiency. PMID: 22366456
11. Mesenchymal precursors expressing Myf5--which are thought to give rise only to brown adipocytes and skeletal muscle--also give rise to a subset of white adipocytes. PMID: 22940198
12. Myf5 mRNA, together with microRNA-31, which regulates its translation. PMID: 22770245
13. Upregulation of myf5 mRNA and a decrease of myoD protein level during leucine starvation. PMID: 22079119
14. Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. PMID: 21527258
15. Myf5-dependent myogenesis is insensitive to genotoxins PMID: 21212806
16. Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation, and both Zic2 and Myf5 require noggin for their activation PMID: 21211521
17. Notch1 activates the expression of regulatory transcription factors such as Sox9, Pax6, Runx1, Myf5 and Id proteins that are critically involved in lineage decisions in the absence of protein synthesis. PMID: 20628604
18. These results reveal a novel genetic network, comprising a Pax3/Dmrt2/Myf5 regulatory cascade that operates in stem cells of the epaxial dermomyotome to initiate skeletal muscle formation. PMID: 20368965
19. Data demonstrated that Myf5 is Tceal7 upstream transactivators using transcriptional assays. PMID: 20307260
20. Hox genes produce global patterns in the axial skeleton; Myf5 and Myf6 have roles in rib formation PMID: 20412779
21. DUX4c induces the MYF5 protein and myoblast proliferation, and has a role in facioscapulohumeral muscular dystrophy PMID: 19829708
22. early epaxial enhancer is essential for the initial expression of the skeletal muscle determination gene Myf5 but not for subsequent, multiple phases of somitic myogenesis PMID: 12223413
23. Myf5 expression in somites and limb buds of mouse embryos is controlled by two distinct distal enhancer activities PMID: 12783799
24. Myf5 and MyoD activation define independent myogenic compartments during embryonic development. PMID: 12798290
25. results showed a positive correlation between NOS-Imu and myf5 expression in regenerating muscles of mdx mice PMID: 12798794
26. To identify the elements involved in the regulation of Myf5 in adult muscle, we analysed reporter gene expression in a transgenic bacterial artificial chromosome (BAC) deletion series of the Mrf4/Myf5 locus. PMID: 15328025
27. skeletal muscle is present in the new Myf5:Myod double-null mice only when Mrf4 expression is not compromised PMID: 15386014
28. in the absence of Myf5 and MyoD, the esophageal muscle cells failed to develop the striated phenotype of acetylcholine receptors PMID: 15497153
29. Myf5 has a role in development of the intercostal muscles and the rib cage PMID: 15580568
30. there are both positive and negative regulatory functions for Gli2 and Gli3 in the control of Myf5 activation in the epaxial muscle progenitor cells and in dorsoventral and mediolateral patterning of the somite PMID: 15604102
31. role of contractile activity of respiratory muscles in fetal lung growth and cell differentiation was examined using Myf5-/-:MyoD-/- mouse embryos PMID: 15844178
32. The presence of all other musculature in Myf5-/- fetuses may allow for normal sternal fusion despite vastly reduced ribs. PMID: 16208536
33. Myf5 functions toward myoblast proliferation. PMID: 16275751
34. Data show MyoD, Myf5, and the calcineurin pathway developmentally activate myosin heavy chain genes; findings indicate Myf5 initiates expression of MyHC-emb, while MyoD enhances it PMID: 16584724
35. Results demonstrate that Myf5 is a direct target of Wnt/beta-catenin, and that its full activation requires a cooperative interaction between the canonical Wnt and the Shh/Gli pathways in muscle progenitor cells. PMID: 16936075
36. The data presented here demonstrate that a composite homeo and paired domain-binding motif within the -58/-56 enhancer is required and sufficient for activation of the Myf5 gene in muscle progenitor cells in the limb. PMID: 17301086
37. Control of Myf5 activation in adult skeletal myonuclei requires ERK signaling. PMID: 17481856
38. Myf5 supports efficient skeletal muscle regeneration by enabling transient myoblast amplification. PMID: 17495111
39. Myf5 is a regulator of regenerative myogenesis and homeostasis, with functions distinct from those of Myod and Mrf4. PMID: 17961534
40. Ablating the myf5 lineage is compatible with myogenesis sustained by myf5-independent, myoD-expressing myoblasts, whereas ablation of the myf6 lineage leads to an absence of all differentiated myofibers, although early myogenesis appears to be unaffected. PMID: 18331721
41. Myf5 and Myod1 define different cell lineages with distinct contributions to muscle precursor cells and differentiated myotubes. Individual myogenic cell lineages seem to substitute for each other within the developing embryo. PMID: 18367555
42. regulatory sequences that direct neuronal Myf5 transcription are present in a distal element located between -55 and -54.3 Kb from the Myf5 gene PMID: 19100730

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KEGG: mmu:17877

STRING: 10090.ENSMUSP00000000445

UniGene: Mm.4984