Recombinant Mouse Myosin-10 (Myh10), partial

1. data therefore reveal a role for NMIIA and NMIIB as negative regulators of proliferation in the mammary epithelium. PMID: 28821574
2. A novel mechanism linking epicardial formation and epicardial function to the activity of the cytoplasmic motor protein NMIIB. PMID: 28687623
3. Positional cloning and candidate gene analysis revealed that the EHC phenotype results from a point mutation in a splice donor site of the Myh10 gene, which encodes NMHC IIB. Our studies on the EHC mutant demonstrate a requirement for NMHC IIB in epicardial function and coronary vessel formation, highlighting the importance of this protein in cardiac development and ultimately, embryonic survival. PMID: 29084269
4. Data show that deletion of myosin heavy chain II-A (Myh9)/myosin heavy chain II-B (Myh10) caused severe hydroureter/hydronephrosis at birth. PMID: 28478097
5. cytokinesis failure in megakaryocytes is the consequence of both the absence of NMIIB and a low RhoA activity that impairs NMIIA localization at the cleavage furrow through increased actin turnover. PMID: 27737892
6. The experimental and in silico results suggest two divergent evolutionary pathways: NMIIA and NMIIB evolved to possess S100A4-dependent and -independent regulations, respectively. PMID: 27029887
7. The novel finding that calponin 2 regulates myosin-dependent CTF in non-muscle cells demonstrates a mechanism for controlling cell motility-based functions PMID: 27733037
8. Study suggests that NMIIB remains constitutively active in support of methamphetamine associations, continuing to drive actin polymerization, such that memories associated with methamphetamine can be selectively targeted without the need for retrieval days to weeks after learning PMID: 26239291
9. A central biophysical role for NMIIB in nuclear translocation during 3D invasive migration. PMID: 26261182
10. We have discovered that NMIIB is the major isoform regulating Schaffer collateral inputs, and that this regulation is restricted to early postnatal development. PMID: 25931194
11. regulates morphogenesis of immature nephrons PMID: 25168025
12. These results supported the hypothesis that, like NMHC-IIA, NMHC-IIB associated with herpes simplex virus 1 gB and mediated herpes simplex virus 1 entry. PMID: 25428876
13. Point mutation in Myh10 causes major defects in heart development and ventral body wall closure. PMID: 24825879
14. The C-terminal domain of MYH10 is responsible for the specific localization of myosin II in megakaryocyte contractile ring. PMID: 25185263
15. The results of this study propose a pivotal role of NM II in cytoskeleton organization during microglial activation. PMID: 25150163
16. This study reveals divergent functions for the 2 Myo10 isoforms in controlling both the direction of migration and neuronal morphogenesis during radial cortical neuronal migration. PMID: 23300110
17. The data validate the function of NMII as that of a negative regulator of OL myelination in vivo and provide a novel target for promoting myelin repair in conditions such as multiple sclerosis. PMID: 24470341
18. emerin functions with myosin IIB to polarize actin flow and nuclear movement in fibroblasts, suggesting a novel function for the nuclear envelope in organizing directional actin flow and cytoplasmic polarity. PMID: 24152738
19. These results indicate that MIIB-driven tension or actin dynamics regulate the major pathway for synaptic vesicle retrieval PMID: 24107946
20. NMII plays a role in T-cell polarity and is regulated by upstream signals. PMID: 23818610
21. NMIIB is required for IRE1-alpha aggregation and foci formation under endoplasmic reticulum stress PMID: 23237951
22. In spite of the presence of multiple non-muscle myosin II isoforms, we demonstrate that a single member, NMIIB, plays an essential and non-redundant role in cytokinesis during meiotic cell divisions of the male germline. PMID: 22820068
23. RUNX1-mediated silencing of MYH10 is required for the switch from mitosis to endomitosis, linking polyploidization with megakaryocyte differentiation. PMID: 22395608
24. that the major roles of NM II in vertebrate cell cytokinesis are to bind and cross-link actin filaments and to exert tension on actin during contractile ring constriction PMID: 22393000
25. MHCIIB deficiency causes imbalances in signalling pathways that are responsible for cell polarity determination. PMID: 21785947
26. Data show that CXCL13/CXCR5 facilitated antigen encounter and BCR signaling by promoting membrane ruffling and LFA-1-supported adhesion require a functional actin cytoskeleton and the activity of the motor protein non-muscle myosin II (NM-II). PMID: 21659539
27. myosin IIA and IIB are differentially expressed and localized and have clearly different functions in hepatic stellate cells PMID: 20932596
28. Ozz-E3 as the ubiquitin ligase complex that interacts with and regulates myosin within its fully assembled cytoskeletal structure PMID: 20352047
29. The migration defect in Cln3(-/-) results, in part, from the loss of the CLN3-myosin-IIB interaction. PMID: 20850431
30. Loss of myosin II, VI or VIIa function had no significant effects on rates of endocytic vesicle movement in bone marrow-derived dendritic cells.[myo2a or Non muscle myosin II] PMID: 17615572
31. Results highlight the functions of the N-terminal motor and C-terminal rod domains of NM II and their different roles in cell-cell and cell-matrix adhesion. PMID: 20679233
32. Myosin IIA knockdown significantly increased, whereas myosin IIB knockdown significantly decreased, macropinocytosis with correlating changes in membrane ruffle formation. PMID: 19743471
33. The mRNA levels for myosin IIb increased significantly between 5 and 7 weeks in developing postnatal mice. PMID: 20166551
34. cell volume perturbations are associated with changes in myosin IIB distribution. PMID: 12061817
35. the forward advance of the growth cone is myosin II dependent and involves multiple myosin II isoforms. PMID: 12584251
36. Myosin IIB is involved not in propelling but in directing the cell movement, by coordinating protrusive activities and stabilizing the cell polarity PMID: 14699073
37. NMHC II-B is particularly important for normal migration of distinct groups of neurons during mouse brain development PMID: 15034141
38. we suggest that cyclic myosin II-B assembly and contraction in lamellipodia power 3D fibre movements. PMID: 15654332
39. Both myosin IIA and myosin IIB are localized in nerve terminals. PMID: 16012337
40. the presence of different alternatively 5'-spliced smooth muscle-myosin heavy chain (SM-MHC) isoforms does not dominate the different contractile features of physiologically loaded renal afferent or efferent arterioles PMID: 16316347
41. Deletion of the B1 alternative exon, together with reduced expression of myosin II-B, results in abnormal migration and consequent protrusion of facial neurons into the fourth ventricle. PMID: 16481398
42. Data suggest that non-muscle myosin 2B is important for bipolar shape formation and adhesion owing to its preferential interaction with membrane-associated actin, and the role myosin 2B in retraction prevents over-elongation of myoblasts PMID: 16895968
43. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation. PMID: 17389233
44. These studies show that the scaffolding properties of NM II-B play an important role in cell adhesion, thereby preventing hydrocephalus during mouse brain development. PMID: 17429076
45. Replacement of Myh2a with myosin IIB rescues brain from hydrocephalus and manttains integrity of the spinal canal. PMID: 17519229
46. downregulation of myosin II-B, the major myosin isoform in neurons, is able to increase Abeta deposition, concomitantly altering the subcellular localization of APP PMID: 17727819
47. The results show that NMHC IIB knockdown led to decreased N-RAP levels through proteasome-mediated degradation. PMID: 18615632
48. Expression of full-length human NMHC-IIA and -IIB in 10 T1/2 cells demonstrated that flectin antibody recognizes both isoforms PMID: 18697221
49. The response of dorsal root ganglion (DRG) neurons to Semaphorin 3A gradients can be divided into two steps: growth cone collapse and retraction. Collapse is inhibited by overexpression of myosin IIA or growth on high substrate-bound laminin-1. PMID: 19109430
50. myosin II, directly regulates cellular patterning and alignment within the cochlear sensory epithelium. PMID: 19439495

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KEGG: mmu:77579

STRING: 10090.ENSMUSP00000099671

UniGene: Mm.218233