Recombinant Mouse Neurotrophin-4 (Ntf4)

1. mast cell degranulation and NT4 release serve as upstream events that ultimately trigger long-lasting changes in airway smooth muscle innervation and function following early life insults. These findings suggest that blockade of mast cell degranulation may be a preventative strategy for young children at high risk of asthma. PMID: 26860818
2. BDNF and NT4 play interchangeable roles in gustatory development. PMID: 24378336
3. Data indicate that BDNF, NT3 and NT4 trophic factors were detected in the conditioned medium of both wild-type and Friedreich's ataxia YG8 stem cells. PMID: 23671637
4. during early embryonic development, NT-4 produced in the ganglion and along the projection pathway inhibits cell death through an activated caspase-3 independent mechanism PMID: 22353733
5. The results of the present study demonstrate the post-transcriptional up-regulation of the Cav3.2 T-current through TrkB activation and identify NT-4 as a target-derived factor that regulates the mechanosensitive function of D-hair neurons. PMID: 21892923
6. Suggest that a dysregulated TrkB/NT4/5 axis may contribute to several of the pathological lesions associated with pulmonary fibrosis, including type 2 alveolar cell hyperplasia and the proliferation of fibroblasts. PMID: 21330466
7. the enhancing effects of treadmill training on axon regeneration include NT-4 5 in the proximal stump. PMID: 21623957
8. Findings indicate that NT4 functions at early embryonic stages and is derived from different sources than Bdnf. PMID: 21038447
9. Data show that gustatory neurons are equally dependent on BDNF and NT-4 expression for survival, regardless of what peripheral target they innervate, but taste buds are more sensitive to BDNF than NT-4 removal. PMID: 20575060
10. NT-4, alone or when co-expressed with brain-derived neurotrophic factor, is processed within and secreted by the constitutive secretory pathway PMID: 12970359
11. results suggest that the NT-4 gene knock-in, probably involving increased intestinal intraganglionic laminar ending innervation, altered short-term feeding, in particular by enhancing satiation and sensitivity to CCK. PMID: 15297267
12. NT-4 is not implicated in the development of Meissner corpuscles in murine glabrous skin. PMID: 15722178
13. Requirement for NT-4/5 from within the pathway used by regenerating axons for the successful growth of those axons in peripheral nerves. PMID: 15926911
14. Nt-4/5 gene depletion causes a delay in formation and maturation of the periodontal Ruffini endings by inhibiting the growth of the periodontal nerves at an early stage. PMID: 16477147
15. Epithelial overexpression of NT4 produces distinct gustatory axon morphologies that disrupt initial targeting. PMID: 16500639
16. Moreover, on high-fat access days the alternating NT-4 mutants significantly increased caloric intake by 9% compared to alternating wild types. PMID: 16530962
17. These results suggest that post-traumatic increases in endogenous NT-4/5 may be part of an adaptive neuroprotective response in the injured brain, and that administration of this neurotrophic factor may be useful as a therapeutic strategy following TBI. PMID: 16553773
18. NT4-OE mice had increased innervation to the skin but no increase in sensory neuron number. NT4 overexpression also enhanced hair follicle innervation and the size and density of innervation to Meissner corpuscles. PMID: 16937395
19. Findings indicate that the nt-4/5-depletion causes a delay in the regeneration of the periodontal Ruffini endings, but the delay is shortened by an exogenous administration of NT-4/5. PMID: 17245704
20. These results support the hypothesis that NT-4KO mice have deficits in macronutrient feedback from the gastrointestinal tract. PMID: 17303678
21. NT-4 regulates proliferation and differentiation of the dental epithelium and promotes production of the enamel matrix PMID: 18045880
22. Data show that, in striatal tissue, NT-4 increased up to age P42 and remained constant, thereafter in the cell's soma. PMID: 19173033
23. taste cell progenitors express taste cell markers during early taste bud development but at later stages, lack of innervation becomes prominent in BDNF(-/-)xNT-4(-/-) mice leading to morphologically degenerating taste cells PMID: 19629530

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KEGG: mmu:78405

STRING: 10090.ENSMUSP00000057916

UniGene: Mm.20344