Recombinant Mouse Nuclear receptor subfamily 0 group B member 1 (Nr0b1)

1. CpG methylation within the NR0B1 promoter is not involved in the in vivo regulation of NR0B1 expression, whereas the hyperacetylation of histone H4 and the unmethylation of histones H3K9 and H3K27, and their binding to the NR0B1 promoter results in decondensed euchromatin for NR0B1 activation. PMID: 27281610
2. Sf1 SUMOylation and Dax1 have roles in the physiological cessation of FAdE-mediated Sf1 expression and the resultant regression of the postnatal fetal cortex (X-zone) PMID: 28893949
3. Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3, and Dax1 inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells. PMID: 27601327
4. Data indicate that nuclear receptor subfamily 0 group B member 1 (Nr0b1) interacted with androgen receptor (AR) in Sertoli cells (SCs). PMID: 27431683
5. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells PMID: 25772165
6. Dax1 and Nanog have roles in stabilizing mouse embryonic stem cells and induced pluripotency PMID: 25284313
7. Here we review the current knowledge on properties, functions and mechanisms of DAX1 action. PMID: 25916112
8. Insulin-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin-resistant states. PMID: 23589295
9. Dax1 functions as a negative regulator of Esrrb and Oct3/4, and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of embryonic stem cells. PMID: 23508100
10. Transcriptional differences between mouse embryonic and epiblast stem cells is mediated through a Sox2/Esrrb heterodimer regulating Nr0b1. PMID: 23169531
11. Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9). PMID: 22294746
12. overexpression of DAX-1 had no effect on the retinoic acid-induced differentiation of P19 cells to either endodermal or neuronal cells PMID: 21678401
13. these data reveal that both Dax1(-/Y) mice and patients with X-linked AHC exhibit adrenal failure that is consistent with adrenocortical subcapsular progenitor cell depletion and argue for a significant role of Dax1 in maintenance of these cells. PMID: 21733829
14. These data indicate that LRH-1 and Nanog cooperate to regulate Dax1 expression in mouse embryonic stem cells. PMID: 20937355
15. Dax1 plays an important role in the maintenance of pluripotency in mES cells through interaction with LRH-1 and transcriptional activation of Oct4 and other genes PMID: 20943815
16. DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis PMID: 20080977
17. describe phenotypic spectrum of disorders associated with mutations and reveal how the discovery of naturally occurring mutations is helping to unravel the role in development and disease [review] PMID: 11738790
18. important regulators of steroidogeneisis are present in human skin and its appendages. PMID: 11886523
19. expression is dependent on steroidogenic factor 1 in the developing gonad PMID: 11923472
20. study revealed that the expression of Dax-1 in the adrenal cortex is regulated by androgen and the receptor PMID: 12081648
21. the specificities of LXXLL-related motifs in Dax-1 based on their amino acid sequences play an important role in regulation of orphan receptors. PMID: 12482977
22. Data show that Dax1 plays a crucial role in testis differentiation by regulating the development of peritubular myoid cells and the formation of intact testis cords. PMID: 12538527
23. Wnt4 signaling mediates the increased expression of Dax-1 as the ovary becomes sexually differentiated PMID: 12554773
24. testis phenotype of Dax1 knockout mice reflects the combined effects of Dax1 deficiency in both Sertoli and Leydig cells PMID: 12606353
25. The results reveal that the subcellular localization of Dax-1 is influenced by the presence of Ad4 binding protein/steroidogenic factor 1, and that two regions of Dax-1 have important roles for this process. PMID: 12610109
26. required for testis differentiation PMID: 12679814
27. Required for normal steroidogenic axis development. PMID: 14678822
28. DAX-1 may play a key role in the regulation of Nur77-mediated steroidogenesis in testicular Leydig cells PMID: 15155786
29. Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development. PMID: 15829514
30. upregulation of Sox9 expression depends on the coordinated expression of Dax1, Sry and Tda1 PMID: 15944188
31. The estrogen receptor-related receptor gamma belongs to a new autoregulatory loop that governs DAX-1 gene expression. PMID: 16314306
32. Nr0b1 functions in a novel role in the maintenance of a relatively undifferentiated state and suggest that the failure of conventional murine Nr0b1 knockout attempts may be due to disregulated differentiation. PMID: 16466956
33. DAX-1 expression is regulated during mammary epithelial cell differentiation PMID: 16627587
34. STAT3 and Oct3/4, essential transcription factors for ES cell self-renewal, are involved in the regulation of Dax1 expression. PMID: 18471437
35. Dax1 deficiency on a partial B6 genetic background results in further modulation of gene expression changes that affect both Sertoli cell and germ cell fate PMID: 18633137
36. DAX-1 influences the protein kinase signaling pathways involved in the regulation of the StAR protein and steroidogenesis in mouse Leydig tumor cells. PMID: 18787026
37. These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology. PMID: 19188450
38. Data suggest that Dax1, a novel molecule interacting with Oct3/4, functions as a negative regulator of Oct3/4 in embryonic stem cells. PMID: 19528230
39. Data show that Dax-1 is an essential element in the maintenance of ES cell pluripotency and have implications for the understanding of stem cell function in both physiological and clinical settings where Dax-1 plays a pivotal role. PMID: 19530134
40. DAX-1 inhibits transcriptional activity of HNF4alpha and modulates hepatic gluconeogenic gene expression PMID: 19651776

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KEGG: mmu:11614

STRING: 10090.ENSMUSP00000026036

UniGene: Mm.5180