Recombinant Mouse Nuclear receptor subfamily 2 group E member 1 (Nr2e1)

1. Results demonstrate that social isolation stress during adolescence attenuates an exercise-induced increase in neurogenesis. This effect is most pronounced in the ventral hippocampus. TLX is necessary for the pro-neurogenic effects of exercise during adolescence. PMID: 28972669
2. This study demonstrated that deletion of Tlx impairs motor, cognitive and anxiety-related behaviours during adolescence and adulthood in male and female mice with most effects occurring during adolescence rather than adulthood, independent of housing conditions. PMID: 26970576
3. This study demonstrated that Nr2e1 could be regulated by retinoic acid, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality. PMID: 28427488
4. Nr2e1 deficiency augments palmitate-induced oxidative stress. Nr2e1 deficiency also resulted in decreases in antioxidant enzymes and expression level of Nrf2. PMID: 26649147
5. TLX is essential for SOX2-mediated in vivo reprogramming of astrocytes and itself is also sufficient to induce neurogenesis in the adult striatum. PMID: 26607952
6. TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing. miR-219 suppresses mouse NSC proliferation downstream of TLX. PMID: 26965827
7. At high glucose concentrations in vitro, AdipoR1 regulated the survival of neural stem cells through the p53/p21 pathway and the proliferation- and differentiation-related factors of neural stem cells via TLX. PMID: 26247729
8. role in regulating STAT1 signaling and host defense PMID: 26196739
9. Nr2e1 regulates processes involved in neurite development and terminal retinal cell differentiation. PMID: 26092486
10. we have provided new candidate interacting partners and numerous well-developed testable hypotheses for understanding the pathways by which Nr2e1 functions to regulate neocortex development. PMID: 26204903
11. TLX overexpression promotes beta cell proliferation and decreases cell apoptosis causes significant expression changes of 225 genes. PMID: 26471300
12. data suggest that miR-378 is a novel miRNA that regulates NSC proliferation and differentiation via targeting TLX PMID: 26361139
13. NR2E1 regulates CBX7 and restrains senescence in neural stem cells. PMID: 25328137
14. TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes PMID: 25557355
15. MiR-9 and TLX form a feedback regulatory loop to coordinate the proliferation. PMID: 24901604
16. These results suggest a strong association between hippocampal neurogenesis and cognition, as well as significant contributions of TLX to hippocampal neurogenesis, learning, and memory. PMID: 24927526
17. Results of the current study suggest aggression displayed by TLX null and heterozygous mice involves 5-HT(2A/C) receptors. PMID: 23933143
18. By interacting with its cofactors, Tlx represses its target genes and plays an important role in the maintenance of adult neural stem cells. (Review) PMID: 23415832
19. TLX/NR2E1 and related NRs such as PNR and COUPTFs can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains . The interaction with BCL11A facilitates TLX-mediated repression of the RARb2 gene. PMID: 23975195
20. Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires an F/YSXXLXXL/Y motif. Interactions of NSD1 with liganded NRs require an overlapping LXXLL motif. PMID: 23975195
21. Characterization of TLX expression in neural stem cells and progenitor cells in adult mouse brains PMID: 22952666
22. While brain tumors still form in Tlx mutant mice, these tumors are less infiltrative and rarely associate with the adult neurogenic niches, suggesting a non-stem-cell origin. PMID: 23028043
23. miR-137 forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development. PMID: 22068596
24. Cerebrum and olfactory bulb hypoplasia, hallmarks of the Nr2e1-null mice phenotype, were not fully corrected in animals harboring one functional copy of human NR2E1. PMID: 22290436
25. Tlx affects gene expression in a positive and negative manner in in the neonatal activated neural stem cells and transit-amplifying progenitors. PMID: 21714038
26. Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia. PMID: 21135096
27. our results do not support Nr2e1(frc/frc) mice as pharmacological models for bipolar disorder PMID: 20497236
28. nuclear receptor tailless (Tlx), which in the adult is expressed exclusively in astrocyte-like B cells of the subventricular zone, acts as a key regulator of neural stem cell (NSC) expansion and brain tumor initiation from NSCs PMID: 20360385
29. Introducing an expression vector of Tlx or cyclin D1 that lacks the let-7b recognition site rescued let-7b-induced proliferation deficiency, suggesting that TLX and cyclin D1 are targets for let-7b-mediated regulation of neural stem cell proliferation. PMID: 20133835
30. compared sequence from human, mouse, and the puffer fish Fugu rubripes PMID: 12079282
31. Loss of the tailless gene affects forebrain development and emotional behavior PMID: 12527005
32. Expression of the transcription factor, tailless (tlx), is required for formation of superficial cortical layers. PMID: 12902391
33. TLX maintains adult neural stem cells in an undifferentiated, proliferative state; TLX-expressing cells from adult brains can proliferate, self-renew and differentiate into all neural cell types in vitro PMID: 14702088
34. Tlx underlies a fundamental developmental program of retinal organization and controls the generation of the proper numbers of retinal progenies and development of glial cells during the protracted period of retinogenesis. PMID: 15371513
35. These studies indicate that tlx is an essential intrinsic regulator in the decision to proliferate or differentiate in the developing forebrain. PMID: 15385616
36. Absence of the transcription factor tailless (tlx) leads to premature laminar development and thinning of neocortex. PMID: 15950290
37. Transgenic human NR2E1 was sufficient to fix structural brain & eye abnormalities & hyperaggressiveness in mice deleted for mouse Nr2e1. NR2E1 protein & regulatory sequences are comparable between these species. PMID: 16000615
38. Nr2e1 deletion can significantly alter both synaptic plasticity and dendritic structure in the dentate gyrus PMID: 16289828
39. Data show that in the postnatal mouse retina, the orphan nuclear receptor tailless is strongly expressed in the proangiogenic astrocytes, which secrete VEGF and fibronectin. PMID: 16424942
40. TLX interacts with atrophin1 (Atn1), a corepressor that is involved in human neurodegenerative dentatorubral-pallidoluysian atrophy (DRPLA) and that is essential for development of multiple tissues. PMID: 16702404
41. The results indicate that TLX plays an important role in neural development by regulating cell cycle progression and exit of neural stem cells in the developing brain. PMID: 17901127
42. In the tailless germline mutants, They are less anxious and much more aggressive than controls, In contrast to germline mutants, the conditional mutants are not impaired in fear conditioning. PMID: 17953618
43. TLX (also called NR2E1) regulates adult neural stem cell proliferation in a cell-autonomous manner by controlling a defined genetic network implicated in cell proliferation and growth PMID: 18235445
44. findings demonstrate the crucial role of Tlx in the generation and maintenance of neural stem cells in the adult subventricular zone in vivo PMID: 18794344
45. Here the authors show that miR-9 suppresses TLX expression to negatively regulate neural stem cell proliferation and accelerate neural differentiation. PMID: 19330006

Show More

Hide All

KEGG: mmu:21907

STRING: 10090.ENSMUSP00000019938

UniGene: Mm.287100