Recombinant Mouse Nuclear receptor subfamily 4 group A member 1 (Nr4a1)

1. By facilitating Mff-mediated mitochondrial fission and FUNDC1-required mitophagy, NR4A1 disturbed mitochondrial homeostasis, enhanced endothelial apoptosis and provoked microvascular dysfunction in myocardial ischemia reperfusion injury. PMID: 29744594
2. identify Nur77 as a transcriptional regulator of T cell metabolism, which elevates the threshold for T cell activation and confers protection in different T cell-mediated inflammatory diseases. PMID: 30072431
3. The data show that NR4A1 expression by multipotent progenitors of the spleen limits erythropoiesis and megakaryopoeisis, permitting development to other myeloid lineages. This effect is specific to the spleen, revealing a unique molecular pathway that regulates myeloid bias in an extramedullary niche. PMID: 29282309
4. NR4A1 knockdown interrupted the Mff-related mitochondrial fission and recused Parkin-mediated mitophagy, reducing the hyperglycemia-mediated mitochondrial damage and thus improving renal function. PMID: 30077998
5. we found that either knockdown of Nr4a1 or 3, 3'- Diindolylmethane (DIM), an Nr4a1 antagonist, were able to rescue the effects of SNRPN knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN deletion disorders. We thus concluded that maintaining the proper level of SNRPN is critical in cortical neurodevelopment. PMID: 27430727
6. new insights into the understanding the mechanisms of the effects of Nur77 on LPS-activated microglia PMID: 28729074
7. Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death. PMID: 28622293
8. our data demonstrated that NR4A1 protein physically associates with the WT1 promoter, and enhanced WT1 promoter transactivation and knockdown of WT1 in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 expression. PMID: 28342843
9. These results suggest that berberine-induced activation of AMPK may contribute to hepatic FGF21 expression via NUR77. PMID: 29247651
10. we found that KLF6 transcriptionally cooperates with NUR77 and SF1 PMID: 26874000
11. additional loss of Nur77 in the absence of Bim led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance. PMID: 28947542
12. current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis. PMID: 28411187
13. Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2. Ubiquitinated Nur77 then interacts with p62/SQSTM1, leading to autophagy of dysfunctional mitochondria and alleviation of inflammation. PMID: 28388439
14. New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse. PMID: 28111880
15. Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells. PMID: 28170423
16. Using Nr4a1 transgenic mice, electrically evoked dopamine release was shown to differ between the striosome and matrix compartments of the corpus striatum in a regionally-distinct manner. PMID: 27036891
17. Nur77 was found to be an important modulator in microglia function and attenuated pro-inflammatory mediator production. PMID: 27889907
18. this study shows that in NR4A1-/- mice, inflammatory Ly6Chigh monocytes contribute to rapid development of arthritis in a serum transfer-induced arthritis model PMID: 27600773
19. Nur77 downregulation triggers pulmonary artery smooth muscle cell proliferation and migration in mice with hypoxic pulmonary hypertension PMID: 27871853
20. Our findings may throw light on the function of ApoA4 in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 relative diseases. PMID: 28412351
21. This study demonstrated that NGFI-B plays a role in controlling correct cerebellar development. PMID: 27769911
22. Nur77 modulates the inflammatory state of macrophages by decreasing inflammatory gene expression, inhibits the collagen content of the extracellular matrix of macrophages, and reduces phagocytosis by macrophages. PMID: 26932821
23. Detailed knowledge on the role of Nur77 in maintaining cardiomyocyte Ca(2+) homeostasis and the dual role Nur77 plays in cardiac remodelling will aid in developing personalized therapies against heart failure PMID: 26486271
24. Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells PMID: 25899083
25. NR4A1 functions as a master transcription factor for the development of this novel thymus-specific macrophage subset. PMID: 26091486
26. Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells. PMID: 26634653
27. In both mouse colitis models inflammation was increased in Nur77-/- mice.Overexpression of Nur77 in lipopolysaccharide activated RAW macrophages up-regulated IL-10 and downregulated TNFalpha, MIF-1 and MCP-1 mRNA expression through NFkappaB repression. PMID: 26241646
28. Nr4a1 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions. PMID: 26304965
29. Data show that transcription factor Nr4a1 expression in myeloid cells limits experimental autoimmune encephalomyelitis (EAE) severity. PMID: 26523867
30. Nur77 is a critical negative regulator of Ang II-induced VSMC proliferation, migration, and phenotypic switching via the downregulation of beta-catenin activity PMID: 26597820
31. Mechanistically, NFATc1 induces Nur77 expression at late stage of osteoclast differentiation; in turn, Nur77 transcriptionally up-regulates E3 ubiquitin ligase Cbl-b, which triggers NFATc1 protein degradation. PMID: 26173181
32. Nr4a1 induction is dependent on ERK1/2 and that MKP-1 negatively regulates this induction. PMID: 25657047
33. Pgc-1alpha and Nr4a1 represent candidate genes for linking circadian neurohormone release with functional adaptation and healthiness of retina and photoreceptor cells. PMID: 26393668
34. data support a novel and critical role for Nr4a1 in the regulation of CD8(+) T cell expansion and effector function through transcriptional repression of Irf4. PMID: 26363057
35. Whereas NR4A1, induced by PDGF-BB, suppresses cell growth on a solid surface, it increases anchorage-independent growth. PMID: 25269081
36. Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-beta signalling PMID: 24584437
37. these findings support a protective role of Nur77 in OVA-induced airway inflammation and identify Nur77 as a novel therapeutic target for airway inflammation. PMID: 26170382
38. These data show that GFP-Nur77 inhibited differentiation of oxLDL-treated macrophages into DC. T PMID: 25471687
39. Results show that NR4A1 expression identifies a highly quiescent and distinct population of myeloid-biased LT-HSCs. PMID: 25284014
40. Retinoids induce a Nur77-dependent cell death program in thymocytes activating the mitochondrial pathway of apoptosis. PMID: 25576519
41. Nur77 appears essential for regulating early signaling of liver regeneration by modulating cytokine-mediated inflammatory, apoptotic, and energy mobilization processes PMID: 25307349
42. These observations imply that zearalenone activity interferes with testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and Nur77 expression. PMID: 24512812
43. Nur77 mediates its effects on muscle size by orchestrating transcriptional programs that favor muscle growth, including the induction of insulin-like growth factor 1 (IGF1), as well as downregulation of growth-inhibitory genes, Fbxo32 and Trim63. PMID: 25605333
44. these results suggest that TGF-beta1/ALK5/Smad3 signaling represses the expression of steroidogenic genes via the suppression of Nur77 transactivation in testicular Leydig cells. PMID: 25140527
45. Ectopic induction of Nur77 in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 regulates the expression of integrin beta4 by targeting its promoter activity. PMID: 25326539
46. A role for endogenous MEF2 factors exclusively in hormone/Fsk/cAMP-induced Nr4a1 gene expression in mouse MA-10 Leydig cells. PMID: 24694307
47. This study showed that nurr77 has a similar mRNA expression pattern and low levels of expression at rest. PMID: 24753204
48. Data indicate that Nur77 is an important nuclear hormone receptor in regulation of atherosclerotic plaque formation and represents a promising target for the treatment of atherosclerosis. PMID: 24498071
49. Fasting-induced activation of orphan nuclear receptor Nur77 increases hepatic fibroblast growth factor (FGF)21 expression. PMID: 24885573
50. Accompanied by the substantial decline in apoptosis inducer Nur77, myocardial ischemia/reperfusion induced cardiac dysfunction was manifested as cardiomyopathy and increased Reactive Oxygen Spieces. PMID: 24680679

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KEGG: mmu:15370

STRING: 10090.ENSMUSP00000023779

UniGene: Mm.119