Recombinant Mouse Oxysterols receptor LXR-beta (Nr1h2)

1. LXRbeta was dynamically expressed during dentate gyrus development.LXRbeta plays a central role in orchestrating the timely differentiation of neural progenitor cells within the dentate gyrus, thereby providing a likely explanation for its association with the genesis of autism-related behaviors in LXRbeta-deficient mice. PMID: 29507213
2. Unr is required in vivo for the formation of Unr-containing nucleoplasmic reticulum because these structures are absent in Unr-null trophoblast giant cells. PMID: 28386023
3. LXRbeta is involved in acute and inflammatory pain. PMID: 26846362
4. PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway. PMID: 27394190
5. Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis. PMID: 28420650
6. Ativation of LXRbeta increases AQP2 protein levels in the renal collecting ducts via a posttranscriptional mechanism top regulate water electrolyte balance. PMID: 28052875
7. Saponin-enriched sea cucumber extracts up-regulation hepatic LCR-beta signaling, preventing obesity in mice fed a high-fat diet. PMID: 26440226
8. LXRB in Sertoli cells plays a role in the blood-testis barrier, germ cell epithelium integrity, paracrine action on Leydig cells modulating testosterone synthesis, paratubular smooth muscle function and metabolism, and lipid homeostasis. PMID: 26402841
9. Liver X receptor beta controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue. PMID: 26504234
10. The oxysterol receptor LXRbeta protects against DSS- and TNBS-induced colitis in mice. PMID: 24803164
11. results suggest that LXRbeta, by driving Radial Glial Cells to become oligodendrocytes in the dorsal cortex, is critical for white matter development and CNS myelination. PMID: 24934178
12. Ligand-activated Liver X Receptor beta (LXRbeta) has an important function in cholesterol homeostasis and endogenous Abeta maintenance in neurons. PMID: 24394905
13. ABCA12 regulates the cellular cholesterol metabolism via an LXRbeta-dependent posttranscriptional mechanism. PMID: 23931754
14. A major effect of NCoR KOknockout in macrophages is to derepress LXR, which leads to the induction of lipogenic pathway genes. This causes increased biosynthesis of palmitoleic acid and omega3 fatty acids within macrophages, which exert robust local anti-inflammatory effects and are associated with the in vivo insulin sensitive phenotype. PMID: 24074869
15. BMP macrophage accumulation reduced cholesterol efflux to both apolipoprotein A1 and high-density lipoprotein by 40% and correlated with a 40% decrease in mRNA contents of ABCA1, ABCG1, and liver-X receptor alpha and beta. PMID: 23788762
16. Three new cell surface markers that could be useful to monitor LXR activation, were identified. PMID: 23185273
17. Data indicate that myelin alters the macrophage Phenotype by activating the liver-X-receptor beta (LXRbeta) isoform. PMID: 22984598
18. Results suggest that PIAS1 may serve as a lipogenic regulator by negatively modulating liver X receptors (LXRs) in a SUMOylation-independent manner. PMID: 22969086
19. Liver X receptor beta protects dopaminergic neurons in a mouse model of Parkinson disease. PMID: 22826221
20. Data show that the female LXRbeta(-/-) mice were anxious with impaired behavioral responses but normal locomotion and memory. PMID: 22529354
21. The persistent high urine volume after arginine vasopressin administration was traced to a reduction in aquaporin-1 expression in the kidney of LXRbeta(-/-) mice. PMID: 22323586
22. Data show that protein expression of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4 was downregulated upon LXR activation. PMID: 21398609
23. Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. PMID: 21173252
24. LXRbeta is required to mediate many of the negative side effects of glucocorticoids. Mice lacking LXRbeta (but not LXRalpha) were resistant to dexamethasone-induced hyperglycemia, hyperinsulinemia, and hepatic steatosis. PMID: 21123945
25. ABCA1 contributes to several beneficial effects of the LXR agonist GW3965 in APP/PS1 mice PMID: 20739291
26. Findings suggest that LXRbeta in a complex interplay with estrogens and TGF-beta could play a crucial role in the malignant transformation of the gallbladder epithelium. PMID: 20679224
27. LXRbeta appears to be a major regulator of glucose homeostasis and energy utilization and of fat storage in muscle and visceral white adipose tissue. PMID: 19690071
28. Data suggest that reduction in the level of ApoER2 is the reason for the retarded migration of eurons in LXRbeta(-/-) mice. PMID: 20566868
29. These results suggest that LXRbeta may inhibit neuroinflammation and maintain cholesterol homeostasis PMID: 20467332
30. Thus, based on these findings we propose that LXR ligand such as T0901317, may be useful in the treatment of various inflammatory diseases. PMID: 20175894
31. During liver regeneration LXR activity is abated in spite of increasing intracellular cholesterol levels. PMID: 20044803
32. DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis PMID: 20080977
33. In conclusion, LXRbeta seems to be the main LXR subtype regulating lipogenesis and cholesterol efflux in skeletal muscle. PMID: 19996385
34. LXRbeta(-/-) mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26weeks. PMID: 20079709
35. selective synthetic agonists induce SUMOylation-dependent recruitment of either LRH-1 or LXR to hepatic APR promoters and prevent the clearance of the N-CoR corepressor complex upon cytokine stimulation PMID: 20159957
36. the functional roles of LXR and ABCA1 in cholesterol trafficking processes in caput epididymidis PMID: 19395734
37. A liver X receptor-beta alternative splicing variant LXRBSV acts as an RNA transcript not as a protein. PMID: 19878653
38. Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus PMID: 12610110
39. liver X receptor beta has a flexible ligand-binding pocket that can accommodate fundamentally different ligands PMID: 12819202
40. LXRbeta is detected in the liver starting at 11.5 days postcoitum; later, LXRbeta is more ubiquitously expressed and enriched in tissues of neuronal and endocrine origin. PMID: 15052659
41. LXR-beta receptors are important actors in epididymis function. PMID: 15525595
42. Activation of liver X receptor results in reduction of tissue factor expression. PMID: 15752369
43. crucial role for LXRbeta in retaining cholesterol homeostasis in Sertoli cells PMID: 15761042
44. LXRbeta is required for expression of the cholesterol transporters, ABCA1 and ABCG1 PMID: 15831500
45. by selectively sensing the cholesterol component of a lipid-rich diet, liver X receptors govern the balance between storage and oxidation of dietary fat. PMID: 16054068
46. 24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway PMID: 16524875
47. LXRbeta modulates trabecular bone turnover. PMID: 16869726
48. Laminar flow increases LXR function via a PPARgamma-CYP27 dependent mechanism, which reveals an atheroprotective role for laminar flow exerting on endothelium. PMID: 18096827
49. The network of CD36 regulation by LXR, PXR, and PPARgamma establishes this free fatty acid transporter as a common target of orphan nuclear receptors in their mediation of lipid homeostasis. PMID: 18242221
50. glucose is required for ChREBP functional activity and that LXRs are not necessary for the induction of glucose-regulated genes in liver. PMID: 18292813

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KEGG: mmu:22260

STRING: 10090.ENSMUSP00000073188

UniGene: Mm.968