Recombinant Mouse Paired box protein Pax-3 (Pax3)

1. Zac1 and GPR39 are upregulated by Pax7 but not Pax3. Pax3 plays a different role in myogenic progression than Pax7. PMID: 29079520
2. Mass spectrometry based screening for potential interaction partners revealed that BRAF interacts and phosphorylates PAX3. PMID: 27906130
3. Sequence analysis identified a missense point mutation (c.101G>A) in exon 2 of Pax3 that resulted in a methionine to isoleucine conversion at amino acid 62 of the PAX3 protein PMID: 28381738
4. This study show that Pax3+ satellite cells retain long-term self-renewal ability and express slow-MyHC isoforms after differentiation. PMID: 27014961
5. Pax3 enhances expression of Polysialic acid on neural cell adhesion molecule in NMuMG cells by upregulating ST8Sia II expression and downregulating ST8Sia IV expression. PMID: 27651434
6. PAX3 role in neural tube defects PMID: 28043919
7. The Pax3(GFP) allele proved to be a convenient marker to identify and directly sort heterogeneous populations of melanoma cells within the tumor bulk at each stage of melanoma progression. PMID: 26587692
8. These results demonstrate a requirement for endoglin in descendants of Pax3-expressing vascular cell precursors. PMID: 26481065
9. Results suggest that regional Pax3 expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis PMID: 25330836
10. we show that the ability of Pax3 to induce the skeletal myogenic cell fate occurs at the expenses of the cardiac lineage. PMID: 24677751
11. Pax3 activity is regulated by the Hippo pathway and Pax factors are Hippo effectors. PMID: 25466249
12. Loss of Pax3 expression is associated with craniofacial abnormalities. PMID: 25800090
13. positive input from the neural-specific transcription factor Sox2. Altogether, our data provide important mechanistic insights into the coordinated integration of different signaling pathways on a short Pax3 CRM. PMID: 24815547
14. Inner ear morphology is affected indirectly by neural tube defects in Pax3 mutants. PMID: 24565836
15. We used a combination of comparative genomics and transgenic assays to define and dissect several functional cis-regulatory modules associated with the Pax3 locus PMID: 24098141
16. Transgenic activation of Pax3 cDNA can rescue the closure defect in the beta-catenin mutants, suggesting that Pax3 is a key downstream effector of beta-catenin signaling in the dorsal posterior neuropore closure process. PMID: 24284205
17. Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer. PMID: 24036067
18. Itm2a, which encodes a type 2 transmembrane protein, is a direct Pax3 target in vivo. PMID: 23650549
19. Cells that express Pax3 are characterised by a peripheral glioblast phenotype. PMID: 23527126
20. A role for Pax3 during myogenesis has not been elucidated beyond mammals, so the ancestral role of Pax3 in myogenesis is unclear; study determined that Pax3-expressing somite cells give rise to oesophageal striated muscle and sternohyoid muscle, a process that is Pax3b dependent in zebrafish and is required for efficient ingestion and swallowing. PMID: 23760954
21. Tcof1 acts as a modifier of Pax3 during enteric nervous system development. PMID: 23283078
22. Pax3 induction during embryoid body differentiation results in the upregulation of genes expressed in the presomitic and somitic mesoderm. PMID: 23081715
23. P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness. PMID: 22710718
24. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution. PMID: 23020925
25. these results allow us to propose a mechanism to describe the ordered phosphorylation of Pax3 throughout early myogenesis. PMID: 23058914
26. 73 genes were differentially expressed (56 downregulated, 17 upregulated) in the CXL-Splotch mouse relative to their wild-type controls. PMID: 23024056
27. Pax3/7BP as an essential adaptor linking Pax3/7 with the histone 3 lysine 4 (H3K4) methyltransferase to regulate the proliferation of muscle precursor cells PMID: 22862948
28. the transcription factors Pax3 and Pax9 as redundant regulators of mouse heterochromatin, as they repress RNA output from major satellite repeats by associating with DNA within pericentric heterochromatin PMID: 22983563
29. study shows FGFR4 is specifically up regulated by PAX3-FOXO1; however this FGFR4 over expression does not contribute to PAX3-FOXO1 tumorigenic phenotypes in primary skeletal muscle myoblasts PMID: 21882254
30. the balance of Pax3, Nkx3.2 and Sox9 may act as a molecular switch during the chondrogenic differentiation of muscle progenitor cells, which may be important for fracture healing. PMID: 22768305
31. Cdx proteins operate via direct binding to an evolutionarily conserved neural crest enhancer of the Pax3 proximal promoter PMID: 22457346
32. a novel pathway in the melanocyte lineage, linking FGF2-STAT3 signaling to increased PAX3 transcription. PMID: 21997191
33. inactivating p53 is the only required Pax3 function during neural tube closure and cardiac neural crest development, and inactivating p53 does not require Pax3-dependent transcription regulation PMID: 22216266
34. Melanocyte migration and proliferation are controlled both through the regulation of Pax3 by nonphosphorylated Brn2 and through the regulation of MITF-M by the overall BRN2 level. PMID: 22290434
35. Pax3 promotes the activation of myogenesis in blood vessel-derived cells. PMID: 22159413
36. The characterization of the new mutation expanded our understanding the transactivation and DNA-binding structure of Pax3 protein PMID: 21867959
37. Pitx2c modulates Pax3+/Pax7+ cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis. PMID: 21749861
38. data show that Pax3 is essential for early neural crest progenitor formation, but is not required for subsequent cardiac neural crest progeny morphogenesis involving their migration to the heart or septation of the outflow tract PMID: 21600894
39. results suggest that both Pax3 and Pax7 transcripts are required for commitment of cells to the myogenic lineage, with each transcript having a distinct role PMID: 21421465
40. Expression of full length IRIZIO cDNA also cooperated with PAX3-FOXO1 in the transformation of Arf-/- myoblasts. Given that IRIZIO is expressed at increased levels in rhabdomyosarcoma, it might contribute to rhabdomyosarcomagenesis in humans. PMID: 21177767
41. These studies suggest that Pax3 acetylation results in decreased Hes1 and increased Neurog2 activity, thereby promoting sensory neuron differentiation. PMID: 21169561
42. Foxd3 and Pax3 act together to affect survival and maintenance of cardiac NC progenitors, and loss of these progenitors catastrophically affects key aspects of later cardiovascular development PMID: 21254333
43. Pax3 orchestrates many of the signalling pathways implicated in the activation or repression of myogenesis. PMID: 21143873
44. The miRNA-mediated down-regulation of Pax3 by MyoD regulates terminal differentiation in muscle cells. PMID: 20956382
45. The further demonstrated that Pax3 exhibited genetic interaction with c-Kit by intercrossing the wps and wbs mice. PMID: 20095975
46. Data indicate Pax3 binds Lef1 & the complex binds to Lef1 promoter at Lef1 binding sites to enhance transcription of Lef1. PMID: 20006729
47. Shows reciprocal inhibition between Pax3 and Foxc2 in the mouse embryo; using both genetic approaches and manipulation of external signals in somite explants, demonstrated that the Pax3:Foxc2 ratio modulates myogenic versus vascular cell fates. PMID: 20059958
48. data show that ectopic Pax3 expression in two distinct phenotypically mesenchymal mammalian cell lines induces the formation of multi-layered condensed cell aggregates with epithelial characteristics PMID: 11861759
49. Data show that Pax3 regulates morphogenetic cell behavior and that regulation of a conserved, planar cell polarity/noncanonical Wnt-signaling cascade entailing JNK activation is a function of Pax3 activity PMID: 11861760
50. Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis PMID: 11914272

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KEGG: mmu:18505

STRING: 10090.ENSMUSP00000004994

UniGene: Mm.1371