Recombinant Mouse Pancreas transcription factor 1 subunit alpha (Ptf1a)

1. non-neural progenitor transcription factor Ptf1a alone is sufficient to directly reprogram mouse and human fibroblasts into self-renewable induced neural stem cells capable of differentiating into functional neurons, astrocytes and oligodendrocytes, and improving cognitive dysfunction of Alzheimer's disease mouse models when transplanted PMID: 30030434
2. Ptf1a is regulated by active and repressive inputs integrated through multiple sequence elements within a highly conserved sequence downstream of the Ptf1a gene. PMID: 27350561
3. the Tfap2a and Tfap2b transcription factors were identified as two major downstream effectors of Ptf1a. PMID: 25966682
4. This study demonstrated that the transcription factor Ptf1a is capable of cell autonomously redirecting cortical pyramidal cell identity toward an inhibitory peptidergic fate. PMID: 25878276
5. We provide strong evidence for spatiotemporally context-dependent activity of Ptf1a as a potent gain-of-function trigger of pro-pancreatic commitment. PMID: 25371369
6. Data suggest the role of pancreas-specific transcription factor 1a (PTF1a) in pancreas development in directing differentiation of embryonic stem cells (ESCs) to endocrine cells. PMID: 24375815
7. These data identify Ptf1a as the first gene involved in the segregation of the cerebellum from the more ventral brainstem. PMID: 24733890
8. The results of this study suggested that Ptf1a specify spatial identities of cerebellar neuron progenitors in the neuroepithelium, leading to appropriate production of GABAergic and glutamatergic neurons, respectively. PMID: 24695699
9. The results support a model whereby Ptf1a directs distinct gene expression programs that are established by the interplay of chromatin accessibility, collaborating transcription factors, and the DNA motifs within tissue-specific regulatory enhancers. PMID: 23754747
10. and and V PMID: 23349836
11. Ptf1a-deficient mice lack all inhibitory interneurons in the dorsal horn. PMID: 23616538
12. we demonstrated that misexpression of Ptf1a, but not of Gm13344 or Gm13336, in the notochord, hindgut, cloaca, and mesonephros was sufficient to replicate the Sd phenotype PMID: 23436999
13. We show that Ptf1a expression is significantly upregulated in Sd mutant embryos. PMID: 23437000
14. The Sd heterozygote phenotype was not ameliorated by Ptf1a haploinsufficiency, further suggesting that the developmental defects result from ectopic expression of Ptf1a. PMID: 23437001
15. binding of Rbms3 to the 3'UTR of Ptf1a regulates the production of the Ptf1a protein PMID: 22372950
16. Tlx1/3 and Ptf1a, the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord PMID: 22723691
17. Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of Ptf1a and is regulated by a distant enhancer element. PMID: 22232429
18. miR-18a plays a fine-tuning role in regulating pancreatic progenitors and exocrine cells through the repression of Ptf1a expression. PMID: 22265691
19. Ptf1a-induced Dll1 expression stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining Hes1 expression and Ptf1a protein levels. PMID: 22096075
20. Ptf1a, which plays a role in controlling both amacrine and horizontal cell fates, is a downstream effector of amyloid precursor protein (APP). PMID: 20978902
21. Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development. PMID: 20627083
22. Replacement of Rbpj by Rbpjl in the PTF1 complex drives acinar differentiation by maximizing secretory protein synthesis. PMID: 20398665
23. Nephrin and Neph3 might regulate certain developmental aspects of Ptf1a-positive neurons as homo- or heterooligomers. PMID: 19887377
24. evidence that Ptf1a expression is specifically connected to the acquisition of pancreatic fate by undifferentiated foregut endoderm PMID: 12185368
25. Ptf1 function is inhibited by notch PMID: 15280211
26. Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum. PMID: 16039563
27. Ptf1a function is essential for GABAergic over glutamatergic neuronal cell fates in the developing spinal cord, and provides an important genetic link between inhibitory and excitatory interneuron development. PMID: 16291784
28. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. PMID: 17075007
29. Ptf1a contributes to the differentiation of horizontal cells and types of amacrine cells during mouse retinogenesis. PMID: 17301087
30. These findings indicate that Ptf1a is necessary for the specification and normal production of Purkinje cells and cerebellar interneurons. PMID: 17360405
31. interaction between PTF1a and RBPJ is required for the early stage of pancreatic growth, morphogenesis, and lineage fate decisions PMID: 17938243
32. The dosage of Ptf1a is crucial for pancreas specification, growth, total beta-cell number, islet morphogenesis, and endocrine function PMID: 18591390
33. The trimeric PTF1 complex forms dual autoregulatory loops with the Ptf1a and Rbpjl genes that may maintain the stable phenotype of pancreatic acinar cells. PMID: 18606784
34. Ptf1a is a master regulator, as indicated by a requirement of Ptf1a for the expression of GlyT2 and a set of peptides, including neuropeptide Y (NPY), nociceptin/orphanin FQ (N/OFQ), somatostatin (SOM), enkephalin (ENK), dynorphin (DYN) and galanin (GAL) PMID: 18634777
35. inhibitory and excitatory subtypes of CN neurons are defined by Ptf1a and Atoh1, respectively and, furthermore, provide important insights into understanding the machinery of neuron subtype specification in the dorsal hindbrain. PMID: 19439493
36. Data show that Neurog2 expression is directly regulated by the PTF1-Rbpj complex, identifying Neurog2 as the first neural target of Ptf1a and revealing a bHLH cascade in the specification of GABAergic neurons in the dorsal spinal cord and cerebellum. PMID: 19641016

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KEGG: mmu:19213

STRING: 10090.ENSMUSP00000028068

UniGene: Mm.69647