Recombinant Mouse Paraspeckle component 1 (Pspc1)

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Pspc1

Uniprot No.

Q8R326

Alternative Names

Pspc1; Psp1; Paraspeckle component 1; Paraspeckle protein 1; mPSP1

Species

Mus musculus (Mouse)

Expression Region

1-523

Target Protein Sequence

MMLRGNLKQV RIEKNPARLR ALESAAGESE PVAAAAMALT LAGEQAPPPA PSEEHPDEEL GFTIDIKSFL KPGEKTYTQR CRLFVGNLPT DITEEDFKRL FERYGEPSEV FINRDRGFGF IRLESRTLAE IAKAELDGTI LKSRPLRIRF ATHGAALTVK NLSPVVSNEL LEQAFSQFGP VEKAVVVVDD RGRATGKGFV EFAAKPPARK ALERCGDGAF LLTTTPRPVI VEPMEQFDDE DGLPEKLMQK TQQYHKEREQ PPRFAQPGTF EFEYASRWKA LDEMEKQQRE QVDRNIREAK EKLEAEMEAA RHEHQLMLMR QDLMRRQEEL RRLEELRNQE LQKRKQIQLR HEEEHRRREE EMIRHREQEE LRRQQEGGFK PNYMENREQE MRMGDMGPRG AINMGDAFSP APAGTQGPPP MMGMNMNNRG TIPGPPMGPG PAMGPEGAAN MGTPMIPDNG AVHNDRFPQG PPSQMGSPMG NRTGSETPQA PMSGVGPVSG GPGGFGRGSQ GGNFEGPNKR RRY

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

Gene References into Functions

These findings highlight a role for PSPC1-dependent RNA maturation in the posttranscriptional control of adipose development and function. PMID: 28192372
Specific interaction with the nuclear transporter importin alpha2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles. PMID: 25694451
A protein complex was identified containing PSPC1, PSF and LMX1B, suggesting the existence of this complex in mesodiencephalic dopaminergic neurons. PMID: 23308148
mPSP1 may regulate multiple phases of important nuclear events during spermatogenesis. PMID: 15140795

Subcellular Location

Nucleus, nucleolus.; [Isoform 1]: Nucleus matrix. Cytoplasm. Nucleus speckle.

Protein Families

PSPC family

Tissue Specificity

Isoform 1 is strongly expressed in testis (leptoten spermatocytes, round spematids and Sertoli cells) and moderately in cerebrum, cerebellum, lung, spleen and ovary (at protein level). Isoform 2 is strongly expressed in kidney and moderately in salivary g

Database Links

KEGG: mmu:66645

STRING: 10090.ENSMUSP00000022507

UniGene: Mm.20129

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Recombinant Mouse Paraspeckle component 1 (Pspc1)

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