Recombinant Mouse Peptidyl-prolyl cis-trans isomerase D (Ppid)

1. stimulates mitochondrial permeability transition pore excessive opening, causing endoplasmic reticulum stress through p38 mitogen-activated protein kinase activation, resulting in enhanced sterol regulatory element-binding protein-1c transcription and hepatic steatosis PMID: 29356058
2. Data suggest that mitochondrial functions in osteoblasts during osteogenesis are regulated, in part, by CypD-mPTP axis; CypD appears to contribute to mitochondrial dysfunction in bone inflammation via excessive opening of mPTP. (CypD = cyclophilin D; mPTP = mitochondrial permeability transition pore) PMID: 29679227
3. CypD regulates complex I-induced ROS production in heart mitochondria and modulates the cardioprotective effect of isoflurane, sevoflurane, and desflurane. PMID: 28328748
4. Murine eosinophil necrosis is regulated in vitro and in vivo by cyclophilin D. PMID: 26893161
5. Suggest that cyclosporin A-mediated CypD inhibition may provide a promising therapeutic potential for protecting retinal ganglion cells against ischemic injury-mediated mitochondrial dysfunction. PMID: 24603333
6. Loss of CypD results in changes in a number of mitochondrial proteins and metabolic pathways. PMID: 23262437
7. CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells PMID: 23303179
8. BAX/BAK-independent cell death did not require Cyclophilin D (CypD) expression, an important regulator of the mitochondrial permeability transition pore PMID: 22719850
9. At the whole muscle level, lack of cyclophilin-D does not protect against muscle atrophy, release of mitochondrial pro-apoptotic factors and activation of caspases following denervation. PMID: 21224232
10. mitochondrial permeability transition was increased by hypoxia-reoxygenation but was less in normoxic and hypoxia-reoxygenation Ppif(-/-) than wild type tubules PMID: 21490135
11. These findings point to a possible role of immunophilin signal transduction pathways in astrocytic modulation of neuronal activity at the tripartite synapse. PMID: 21163525
12. Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. PMID: 20942566
13. Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state. PMID: 21173147
14. these data suggest that CypD-dependent mitochondrial permeability transition does not play a major role in neurodegeneration in mnd2 mice. PMID: 20123086
15. the permeability transition pore can form and open in the absence of CyP-D, which is the target for PTP inhibition by Cyclosporin A PMID: 15792954
16. implicate pathological activation of the mitochondrial permeability transition pore in the axonal damage occurring during multiple sclerosis and identify CyPD, as well as the permeability transition pore PMID: 17463082
17. suggest a novel CypD-dependent negative-feedback mechanism regulating arterial thrombosis PMID: 17989312
18. Cyclophilin D-dependent (CyD) mitochondrial permeability transition (CyD-mPT) plays an important role in glutamate-triggered delayed calcium deregulation (DCD) and excitotoxic neuronal death. PMID: 19236863
19. In the absence of Cyp-D, Col6a1(-/-) mice show negligible myofiber degeneration, rescue from mitochondrial dysfunction, and normalized incidence of apoptosis. PMID: 19293339
20. CyPD association to the lateral stalk of ATP synthase modulates the activity of the complex PMID: 19801635

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KEGG: mmu:67738

STRING: 10090.ENSMUSP00000029382

UniGene: Mm.295252