Recombinant Mouse Plasma membrane calcium-transporting ATPase 2 (Atp2b2), partial

1. Early growth response protein 1 regulates promoter activity of alpha-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system PMID: 28532435
2. These findings indicate a novel role for PMCA2 in modality- and sex-dependent pain responsiveness. Female-specific molecular changes potentially account for the altered pain responses PMID: 27702770
3. PMCA2 interacts with HER2 in specific actin-rich membrane domains. PMID: 26729871
4. These results indicate that a significant fraction of the postsynaptic NMDAR current is reliant on a perisynaptic extracellular alkaline shift generated by the PMCA. PMID: 25609607
5. Our results demonstrate that PMCA2 activity is an important regulator of the dendritic calcium equilibrium controlling Purkinje cell dendritic growth PMID: 24288624
6. This study further resolves the interaction between Atp2b2 and Cdh23 in a gene dosage and frequency-dependent manner, and finds that low auditory frequencies are significantly affected by the interaction. PMID: 23792079
7. loss of PMCA2 adversely influences the function and organisation of Purkinje neuron synaptic inhibition PMID: 23568408
8. The Atp2b2 (Deaf13) mutation leads to a p. R561S substitution in the catalytic core. Mice homozygous for these mutations display profound hearing loss. PMID: 23826306
9. Amplitude of depolarization and AMPAR-mediated Ca(2+) transients are significantly higher in cultured PMCA2(+/-) than in PMCA2(+/+) Purkinje cells due to increased Ca(2+) influx. PMID: 22789621
10. G293S and V586M mutations in the PMCA2 Calcium Transporting ATPase of the stereocilia are associated with deafness. (Review) PMID: 22349217
11. Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2. PMID: 22252018
12. PMCA1 but not PMCA2 localization is compromized by the loss of Cav1.4 protein. PMID: 22183401
13. The murine mutant of PMCA2 overexpressed in model cells (HeLa) displayed an evident defect both in the basal activity of the Ca(2+)pump and in the long range ejection of Ca(2+). PMID: 22047666
14. Whole cell patch clamp recordings from PMCA2-/- PNs revealed that they possessed hyperpolarised membrane potentials, reduced frequency and increased irregularity of spontaneous action potential firing. PMID: 21232211
15. Data link the reduction in PMCA2 expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE. PMID: 20489728
16. PMCA2 missense mutation, Tommy, impairs cytosolic calcium clearance in hair cells and Tommy mice show hearing impairment. PMID: 20826782
17. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer PMID: 20534448
18. Although PMCA2(+/-) mice exhibited outwardly normal behaviour and little change in their gait pattern, when challenged to run on a narrow beam they exhibited clear deficits in hindlimb coordination. PMID: 20083513
19. In homozygous mice structural changes in cochlear hair cells, spiral ganglion neurones and spherical cells in the cochlear nucleus result from PMCA2 mutation and the subsequent accumulation of toxic levels of calcium that alter their functional integrity. PMID: 11875276
20. Fifteen days following an 8 h, 113 dB noise exposure, Pmca2+/- mice displayed significant permanent threshold shifts at 16 and 32 kHz that were 15 or 25 dB greater than those observed in Pmca2+/+ littermates. PMID: 11950541
21. PMCA2 is localized to rod bipolar cells, horizontal cells, amacrine cells, and ganglion cells PMID: 12209837
22. the activity of PMCA2bw is required for secretion of much of the calcium in milk PMID: 15302868
23. Hearing loss and ataxia are dependent on gene dosage and PMCA2 dysfunction. PMID: 15350283
24. PMCA2, located in hair cell stereocilia, contributes significantly to endolymph calcium maintenance. PMID: 15357414
25. Loss of motor neurons in the spinal cord of PMCA2 null and PMCA2 dfw(23) functionally null mutation mice. PMID: 15576480
26. Decrease in PMCA2 transcript and protein levels and correlation between expression and disease course in two different allergic encephalomyelitis models further highlight the importance of this calcium pump in neuronal dysfunction during inflammation. PMID: 15926914
27. PMCA2-mediated Ca2+ extrusion modulates the amplitude and timing of the high-sensitivity rod pathway to a much greater extent than that of the cone pathway PMID: 16822977
28. Fast PMCA2 isoform strongly influences development and maintenance of cerebellar function. PMID: 17409239
29. even partial reductions in PMCA2 levels are sufficient to cause delayed death of motor neurons in disease PMID: 18848933
30. Oblivion, a new Atp2b2 mutant showed a missense mutation (2630C-->T) in exon 15, causing a serine to phenylalanine substitution (S877F) in transmembrane domain 6 of the PMCA2 pump, the resident Ca(2+) pump of hair cell stereocilia,leading to deafness PMID: 18974863
31. The deaf-waddler isoform of PMCA2, operating at 30% efficacy, showed a significantly decreased ability to rescue the Ca(2+) loading of cells expressing TRPML3(A419P). PMID: 19299509

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KEGG: mmu:11941

STRING: 10090.ENSMUSP00000086398

UniGene: Mm.321755