Recombinant Mouse Poliovirus receptor-related protein 1 (Pvrl1), partial

1. finding suggests that necroptosis is responsible for GalN/LPS-induced liver injury through DAMP-activated PRR signaling. PMID: 28752362
2. Nectin-1 promotes chlamydial infection in the female genital tract but does not appear to contribute to rectal infection in male mice. PMID: 27486990
3. nectin-1 regulates the neuronal activities in the CA3 region of the hippocampus. PMID: 26663531
4. Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4. It's implicated in prolactin receptor signaling for mammary gland development. PMID: 26757815
5. The synergistic action of nectins generates mosaic pattern, which cannot be achieved by a single mechanism. PMID: 26929452
6. These results indicate that the nectin-1 spots regulate the branching of mitral cell dendrites in the deep sub-lamina of the EPL and suggest that the nectin-1 spots are required for odor information processing in the olfactory bulb. PMID: 26169026
7. Results indicate that the nectin-1 spots constitute a novel adhesion apparatus that tethers mitral cell dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb PMID: 25967681
8. results demonstrate a role for both nectin-1 and HVEM as receptors and suggest a further receptor which appears much less efficient. PMID: 26136572
9. In summary, herpes simplex virus 1 entry into epidermis was shown to strongly depend on the presence of nectin-1, but the restricted presence of HVEM can potentially replace nectin-1 as a receptor. PMID: 25320325
10. This study demonstrated that nectin1- and nectin3-mediated interactions between Cajal-Retzius cells cells and migrating neurons are critical for radial migration PMID: 23931996
11. PRR1 nectin-1 plays a role in the formation of intimal thickening after carotid artery ligation. PMID: 23539219
12. Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia. PMID: 23213272
13. These results suggest that differences in nectin-1 and HVEM receptor expression between adults and newborns may partially explain differences in susceptibility to herpes simplex 2. PMID: 23097453
14. Loss of presenilin 1/gamma-secretase activity delays processing of nectin-1 and causes accumulation of its full-length and carboxyl-terminal fragments. PMID: 21910732
15. The authors report that either HVEM or nectin-1 must be present for HSV-1 infection of the cornea. PMID: 21795335
16. hair cells and supporting cells express nectin-1 and -3, respectively; their interaction mediates the heterotypic adhesion between these 2 cell types; nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia PMID: 21798896
17. Results suggest that heterophilic interaction between nectin-1 and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation. PMID: 21038445
18. Nectins asymmetrically localize at puncta adherentia junctions and at synaptic junctions. Inhibition of the nectin-based adhesion by an inhibitor of nectin results in a decrease in synapse size and a concomitant increase in synapse number. PMID: 11827984
19. Nectin-1alpha is an immunoglobulin-like receptor involved in the formation of synapses and is a substrate for presenilin/gamma-secretase-like intramembrane proteolytic activity PMID: 12376527
20. primary receptor for HSV-1 infection of mouse sensory neurons PMID: 12584355
21. regulates the velocity of the formation of the E-cadherin-based adherens junctions and the subsequent formation of the claudin-based tight junctions PMID: 12788073
22. importance of nectin-1 in mediating viral entry for both HSV-1 and HSV-2 in the genital mucosa in female hosts PMID: 14963155
23. nectins and afadin are involved in dynamic epithelial remodeling during mouse development PMID: 15108322
24. regulation of E-cadherin-based adhesion involving cellular nectin-1 trans-interacting with nectin-3 is qualitatively different from that involving cellular nectin-3 trans-interacting with nectin-1 and depends on the nectin levels expressed by cells PMID: 15550395
25. integrin alpha(v)beta3 and nectin play pivotal roles in the cross-talk between cell-matrix and cell-cell junctions and the formation of cadherin-based adherens junctions PMID: 16679515
26. The axon-biased localization of Nectin 1 and its trans-interaction with Nectin 3 in cooperation with the cadherin machinery is critical for the ordered association of axons and dendrites. PMID: 16801389
27. results indicate that nectin-1-dependent events occurring at the plasma membrane during cell-cell spread of herpes simplex virus type 1 were equivalent to those for virus entry PMID: 16823958
28. Discrete nectin-1 immunopositivity was observed in regions susceptible to herpes simplex virus infection in specific developmental phases of central nervous system PMID: 16877297
29. nectin-1 plays a key role in the expression of loricrin in the epidermis PMID: 17472964
30. While nectin-1 proved not to be essential for herpex simplex infection of the nervous system, it is required for the full manifestations of disease, as seen in knockout mice. PMID: 18005714
31. These data indicate that the synaptic localization of nectin-1 and l-afadin are F-actin-dependent and that the shedding of nectin-1 is a mechanism contributing to synaptic plasticity. PMID: 18181141
32. Soluble forms of the first Ig-like domain of nectin-1 (PHveC-VhIg and PHveC-VpIg), but not those of the entire ectodomain (PHveCIg and PHveCpIg), lead to microphthalmia and lack of vitreous body in the transgenic mice. PMID: 18204934
33. study has shown for the first time that nectin-1 has a fundamental role in murine amelogenesis PMID: 18703497
34. expressed in early epithelial structures of the nephron generated from metanephric mesenchyme PMID: 19116242
35. expression of nectin-1 is necessary for HSV infection via the intracranial route and for encephalitis PMID: 19805039

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KEGG: mmu:58235

STRING: 10090.ENSMUSP00000034510

UniGene: Mm.335096