Recombinant Mouse Programmed cell death 1 ligand 2 (Pdcd1lg2), partial

1. Data demonstrates that during Fasciola hepatica infection, the PD-L2 signaling pathway is involved in alternative macrophage polarization as well as in the control of the underlying Th1-type immune response, and concomitantly plays a key role in determining the susceptibility to this heminth infection. PMID: 27783986
2. PD-L1 and PD-L2 in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin. PMID: 28777458
3. this study demonstrates that PD-L2 regulates the production of natural Abs against phosphorylcholine PMID: 28768724
4. findings indicate that the PerC B cells, including PD-L1/PD-L2 B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection PMID: 28570665
5. this study shows that PD-L2 is essential for effective CD4+ T cell immunity and determines the severity of malarial infections PMID: 27533014
6. injection of gene knockdown-dendritic cells induces intra-tumor T cell infiltration and release of inflammatory cytokines PMID: 26599163
7. The endogenous PD-1/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis. PMID: 26043977
8. PD-L1 and PD-L2 are nonredundant aspects of the natural protective response to ischemic injury and may be novel therapeutic targets for Acute kidney injury. PMID: 25404361
9. long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2. PMID: 26162855
10. demonstrate that subcategorizing memory B cells on the basis of their expression of CD80 and PD-L2 PMID: 24880458
11. In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells. PMID: 24098455
12. Blockade of PD-L2 and RGMb interaction prevented the development of respiratory tolerance PMID: 24752301
13. Endogenous IL-21, therefore, has potent and specific effects on mucosal antiviral responses, assisting viral clearance, regulating pulmonary T- and B-cell responses, and inhibiting IL-17 production. PMID: 23149662
14. Host PD-L1 is dominant over PD-L2 expression in regulating graft-versus-host disease lethality. PMID: 24030385
15. Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity. PMID: 23174661
16. PD-L2 induction on dendritic cells exposed to Mycobacterium avium downregulates BCG-specific T cell response. PMID: 21147037
17. results demonstrate that PD-L2 is involved in the arginase/inducible nitric oxide synthase balance during Trypanosoma cruzi infection PMID: 21303364
18. Deficiencies of B7-H1 and B7-DC abrogated oral tolerance, accompanied by enhanced antigen-specific CD4(+) T-cell response and IgG(1) production. PMID: 20574047
19. PD-L2(-/-) mice show increased airway hyperreactivity and enhanced production of IL-4 by iNKT cells PMID: 19741598
20. PD-L2 expression is regulated by two different promoters that function in a lineage-specific manner, with the B-1-specific promoter being constitutively active as a result of Oct1 and Oct2 binding. PMID: 19710692
21. B7-DC plays a critical inhibitory role in controlling the exaggerated T helper type (Th)2 responses induced by Nippostrongylus brasiliensis infection. PMID: 20065112
22. B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes. PMID: 19757438
23. The expression of PD-1/PD-L1, L2 is upregulated in EAH and regulated by IFN-gamma and IL-4. PD-1 system may play an important role in the pathogenesis of autoimmune hepatitis. PMID: 19781375
24. expression patterns of PD-L1 and PD-L2 with the cells of lymphohematopoietic tissues exclusively expressing the former PMID: 12161284
25. B7-DC expression is inducible on macrophages and dendritic cells upon stimulation with IFN-gamma, GM-CSF, or IL-4. PMID: 12421930
26. most normal tissues and cardiac isografts had minimal expression of PD-1, PD-L1, or PD-L2, but intragraft induction of all three molecules occurred during development of cardiac allograft rejection PMID: 12444166
27. molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction PMID: 12719480
28. Data show that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. PMID: 12810690
29. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. PMID: 12847135
30. A unique role is suggested for B7-DC in the regulation of asthmatic response through an IFN-gamma-dependent, but programmed death-1(PD-1)-independent, mechanism. PMID: 14764726
31. T-cell-associated B7-H1 and B7-DC negatively regulate the T-cell response via the T-T interaction PMID: 16236366
32. PD-L1 and PD-L2 differentially regulate the susceptibility and chronic progression of EAE in a strain-specific manner PMID: 16517716
33. Results demonstrate that PDL2 negatively regulates T cells in immune responses and plays an essential role in immune tolerance. PMID: 16864790
34. Blockade of PD-1 or B7-H1, but not B7-DC, at the time of self-antigen encounter mitigates tolerance induction and results in CD8 T-cell differentiation into functional cytolytic T lymphocyte PMID: 17392506
35. Contributes to the poor stimulatory capacity of immature dendritic cells, which have a hypothetically inhibitory bias. PMID: 17412283
36. extend the range of known PD-L2 expression to B cells and show that B1 cells identified by this marker express a specific repertoire associated with anti-bacterial immunity PMID: 17683117
37. PD-1/PD-L pathway has an important role in downregulating proatherogenic T cell response and atherosclerosis by limiting APC-dependent T cell activation. PMID: 17853943
38. PD-L1 and PD-L2 function differently in regulating alloreactive T-cell activation in vivo, and PD-L2 is predominant in this graft vs host disease model in limiting alloreactive CD8(+) T-cell proliferation. PMID: 17924994
39. The PD-L2 provide distinct negative regulatory checkpoints poised to suppress autoimmune renal disease. PMID: 18025191
40. PD-1/PD-L pathway has a key role in the regulation of antifungal immunity PMID: 18268348
41. analysis of the crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2 PMID: 18641123
42. suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid dendritic cells PMID: 19342693
43. Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model. PMID: 19724910

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KEGG: mmu:58205

STRING: 10090.ENSMUSP00000108195

UniGene: Mm.116737