Recombinant Mouse Proheparin-binding EGF-like growth factor (Hbegf), partial

1. via binding to hypoxia-responsive elements in MMP9 gene, HIF1alpha stimulated MMP9 expression, and therefore appeared as a prominent intermediary in HB-EGF-induced blood-brain barrier damage PMID: 27431094
2. Using the best available methods for preclinical evaluation in animal models, it is likely that HB-EGF-like growth factor treatment leads to regeneration of chronic tympanic membrane perforations and restoration of the tympanic membrane to normal function, suggesting a potential route for nonsurgical treatment. PMID: 28142401
3. In a clinically relevant CADASIL mouse model, we show that exogenous ADAM17 or HB-EGF restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-induced deficits. PMID: 27476853
4. HB-EGF Tg mice were shown to develop more severe liver fibrosis when treated with carbon tetrachloride or bile duct ligation, with increased matrix metalloproteinases 13 activity and enhanced expression of fibrogenic genes including alpha-smooth muscle actin and collagen I. PMID: 28864379
5. These results indicate that ATX-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways. PMID: 28588064
6. our results suggest that shedding of HB-EGF from endothelium plays an important role in Ang II-induced renal injury by linking Ang II-AT1R with EGFR transactivation. PMID: 27226110
7. Results suggest that HB-EGF secreted from KRas-mutated colorectal cancer cells promotes intestinal myofibroblasts migration through ERK and JNK activation, which, in turn, could support cancer progression. PMID: 28339087
8. this study revealed that HB-EGF as well as HGF inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively. PMID: 27779646
9. Abnormal keratinocyte migration and down-regulated expression of the Hbegf gene might be associated with impaired eyelid development in B6-Co mice. PMID: 27706598
10. Psychiatric, social-behavioral and cognitive abnormalities were also observed in hippocampal Hbegf knockout mice. PMID: 26637193
11. HB-EGF promotes enteric neural stem cell proliferation and migration in a mouse model PMID: 25806717
12. mice in which DTR is expressed on conventional Dendritic cells display marked lymph node hypocellularity and reduced frequency of Dendritic cells in the same organs but not in spleen or nonlymphoid tissues. PMID: 25411201
13. Decreased nitric oxide bioavailability leads to increased HB-EGF expression, which may be an important mediator of the resulting progressive diabetic nephropathy in eNOS-knockout diabetic mice. PMID: 23760291
14. HB-EGF changed morphology of 2D and Bioactive3D cultured astrocytes toward a radial glia-like phenotype and induced the expression of intermediate filament and progenitor cell marker protein nestin. PMID: 24188029
15. HB-EGF induction on Snail expression is dependent on the EGFR-ERK-Stat3 pathway. PMID: 23994020
16. HB-EGF did not prevent the TGF-beta-induced nuclear accumulation of Smad3, but did lead to stabilization of the Smad transcriptional co-repressor TG-interacting factor PMID: 23743191
17. HB-EGF induced heart fibrosis and proliferation of cardiac fibroblasts occurs through activation of the Akt/mTor/p70s6k pathway PMID: 22984591
18. HB-EGF gene knockout increases susceptibility to peritonitis-induced intestinal injury, which can be reversed by administration of HB-EGF. These results support a protective role of HB-EGF in peritonitis-induced sepsis. PMID: 22703966
19. HB-EGF plays a pivotal role in synaptic plasticity and memory formation. PMID: 21945083
20. Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice. PMID: 22330337
21. Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor. PMID: 22291012
22. Our results demonstrate that HB-EGF is an important factor involved in the healing of intestinal anastomoses. PMID: 20850767
23. This study indicated that HB-EGF may play a pivotal role in ischemia and reperfusion injury and that endogenously synthesized HB-EGF is necessary for both the neuroprotective effect and for regulation of cell proliferation in the subventricular zone. PMID: 21524692
24. Overexpression of HB-EGF increases resistance to hemorrhagic shock and resuscitation in mice. PMID: 20965535
25. Results indicate that extracellular heparan-sulfate proteoglycans sequester the transmembrane pro-form of heparin-binding EGF-like growth factor at the point of cell-cell contact, governing the balance between juxtacrine vs. autocrine/paracrine signaling. PMID: 20530570
26. Data demonstrated that overexpression of airway HB-EGF induced by IL-17 secreted from redundant expanding Th17 cells might contribute to excessive mucus expression and ASM proliferation in chronic asthma. PMID: 20530256
27. These results indicate that interactions with HSPGs are essential for the function of HB-EGF, especially in cardiac valve development, in which HB-EGF suppresses mesenchymal cell proliferation. PMID: 20530548
28. alterations affecting HB-EGF signaling could comprise a contributing factor in psychiatric disorder, as shown in a knockout mouse model PMID: 19829704
29. Exogenously administered diphtheria toxin (DT) binds to and damages cells expressing the human precursor of heparin binding-EGF-like growth factor (proHB-EGF), also known as the diphtheria toxin receptor (DTR). PMID: 19850947
30. role in regulating mesangial cell hexokinase activity and expression PMID: 11782486
31. selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1 PMID: 12213819
32. HB-EGF activation of receptor tyrosine kinases is essential for normal heart function. PMID: 12621152
33. An elevation in HB-EGF protein in pancreatic islets led to altered interactions among islet cells and among islets, stromal tissues, and ductal epithelium involving altered cell adhesion. PMID: 12671899
34. cardiac valvulogenesis is dependent on EGFR activation by TACE-derived soluble HB-EGF, and that EGFR signaling is required to regulate bone morphogenetic protein signaling PMID: 12773386
35. HB(uc/uc) mice developed severe heart failure and enlarged heart valves, phenotypes similar to those in proHB-EGF null mice. Ectodomain shedding of proHB-EGF is essential for HB-EGF function in vivo and requires strict control. PMID: 14597776
36. Lysophosphatidic acid accelerates blastocyst differentiation through its ability to induce Ca2+(i) transients and HB-EGF autocrine signaling PMID: 15149861
37. the heparin-binding domain serves as a negative regulator of heparin-binding EGF-like Growth Factor PMID: 15331606
38. HB-EGF is a key factor for hepatocyte progression through G(1)/S transition during liver regeneration PMID: 15536070
39. HB-EGF is a mediator of multiple physiological and pathological pathways [review] PMID: 15621728
40. role for PI3K/Akt and MEK/ERK signaling in HB-EGF-stimulated cell proliferation PMID: 15952178
41. HB-EGF is not required for arteriogenesis or angiogenesis in hindlimb ischemia PMID: 15994441
42. Overexpression of Hbegf in transgenic mice downregulates Igfbp3 and Igfbp4 and mRNA. PMID: 16019424
43. HB-EGF secreted from the tip of the leading edge activates the EGFR and ERK pathway, and that synergy with TGFalpha is required for leading edge extension in epithelial sheet migration during eyelid closure. PMID: 16141218
44. EGF may have a role in accelerating expression of integrin alphanubeta3 in peri-implantation mouse embryos PMID: 16622802
45. Expression of HB-EGF in smooth muscle and/or endothelial cell lineages is essential for proper heart development and function in mice. PMID: 17010937
46. These findings demonstrate that amino-terminally truncated, membrane-bound form of HB-EGF stimulates cell proliferation but lacks insulin-like signalling. PMID: 17472728
47. HB-EGF has a novel suppressive function that contributes to decelerating distal lung cell proliferation synergistically with TGFalpha through EGFR in perinatal distal lung development. PMID: 18069687
48. HB-EGF signaling is required for low flow-induced hypertrophic remodeling and may participate in vascular wall disease and remodeling PMID: 18436796
49. Endogenous HB-EGF significantly enhances healing by restitution, prolongs survival, and enhances angiogenesis in mice subjected to intestinal I/R injury. PMID: 18558204
50. a novel characteristic of regulatory macrophages is the production of angiogenic HB-EGF. PMID: 19201846

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KEGG: mmu:15200

STRING: 10090.ENSMUSP00000025363

UniGene: Mm.289681