Recombinant Mouse Prolow-density lipoprotein receptor-related protein 1 (Lrp1), partial

1. the intracellular domain of Lrp1 interacts with the nuclear receptor Ppargamma, a central regulator of lipid and glucose metabolism, acting as its transcriptional co-activator in endothelial cells. PMID: 28393867
2. LRP1 mediates cell adhesion by orchestrating a multi-protein pathway to activate, traffic and degrade integrins. Thus, LRP1 may serve as a focal point in the integrin quality control system to ensure a firm connection to the extracellular matrix. PMID: 29116364
3. Collectively, these studies reveal a novel role for Lrp1 in peroxisome biogenesis, lipid homeostasis, and OPC differentiation during white matter development and repair. PMID: 29251594
4. A knockin mouse model was used to uncover a novel atheroprotective role for LRP1 in macrophages where tyrosine phosphorylation of an NPxY motif in its intracellular domain initiates a signaling cascade along an LRP1/SHC1/PI3K/AKT/PPARgamma/LXR axis to regulate and integrate cellular cholesterol homeostasis through the expression of the major cholesterol exporter ABCA1 with apoptotic cell removal and inflammatory respon... PMID: 29144234
5. MMP-9 activation by hypoxia requires LRP1 and Pyk2 phosphorylation in fibroblasts. PMID: 28378397
6. Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK and Akt activation. PMID: 27258849
7. FVIIa-antithrombin but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin in vivo PMID: 27614059
8. Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli. PMID: 28972143
9. In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis. PMID: 27400748
10. Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis. PMID: 28867180
11. This study demonstrated that LRP1 suppresses microglial activation by modulating JNK and NF-kappaB signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation PMID: 27931217
12. These results provide evidence supporting a key role for the p38 MAPK signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo. PMID: 27163530
13. BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response. PMID: 28596374
14. report that LRP1 expression is rapidly lost as oligodendrocyte progenitor cells differentiate, and is absent from all oligodendrocytes, including newborn oligodendrocytes PMID: 27280679
15. Results show evidence of low-density lipoprotein receptor-related protein 1 ( (LRP1) expression and activity modulation by Intravenous immunoglobulin (IVIg), and support the role of LRP1 as a partner of IVIg in the execution of its neuroprotective effects. PMID: 27181517
16. LRP1 deficiency in mature adipocytes promotes diet-induced inflammation and atherosclerosis. PMID: 28473440
17. TNF-alpha blockade exerts antiatherosclerotic effects that are dependent on the presence of macrophage LRP1. PMID: 27365402
18. these results documented that LRP1 deficiency in hepatocytes promotes lipid accumulation and lipotoxicity through lysosomal-mitochondrial permeabilization and ER stress that ultimately result in cell death. Hence, LRP1 dysfunction may be a major risk factor in fatty liver disease progression. PMID: 27317662
19. A critical role was determined for astrocytic LRP1 in brain for clearing amyloid-beta accumulation. PMID: 28275161
20. Findings provide evidence for a central role of LRP1 in overall energy homeostasis, and specifically liver glucose and fatty acid metabolism. Its somatic inactivation in the liver predisposes to diet-induced insulin resistance with dyslipidemia and non-alcoholic hepatic steatosis. PMID: 27322467
21. Studies demonstrate a role for ADAM10 in the ectodomain shedding of LRP1 in the brain and the clearance of Abeta across the blood-brain barrier, which may provide a novel strategy for attenuating Abeta accumulation in the AD brain PMID: 27503326
22. Study demonstrated that 1,25(OH)2D3, the active form of vitamin D, plays an important role in increasing Abeta1-40 vectorial transport from the brain to blood and systemic clearance from peripheral circulation through increasing LRP1 levels both in vivo and in vitro, and reducing RAGE level in the blood-brain barrier model in vitro PMID: 26820600
23. extracellular (alpha) chain of LRP1 mediates TGFbeta-induced enhancement of Wnt5a, which limits intracellular cholesterol accumulation. PMID: 26792864
24. conclude that LRP1, NFkappaB, and miR-155 function as members of a previously unidentified system that has the potential to inhibit or sustain inflammation PMID: 26787872
25. This study demonstrated that bexarotene rescues aging-related declines of synaptic proteins through a neural LRP1-mediated pathway presumably by increasing apoE levels and lipidation. PMID: 26688581
26. LRP1 interacts with beta1-integrin mediating integrin internalization and thus correlates with downstream signaling of beta1-integrin such as focal adhesion dynamics. PMID: 26610862
27. Selective deletion of Lrp1 in the brain endothelium of C57BL/6 mice strongly reduced brain efflux of injected [125I] Abeta(1-42). PMID: 26619118
28. Suggest role for LRP1/PARP1 signaling in endothelial cell proliferation and retinal neovascularization induced by hypoxia. PMID: 26634655
29. The LRP1/Pyk2 axis represses SERCA2 mRNA expression via HIF-1a. PMID: 25968337
30. Lrp1 mediates the internalization of non-phosphorylated cathepsins. Lrp1 inhibitor increased the secretion of cathepsins. PMID: 25786328
31. we detected the thymic expression of receptors responsible for endocytosis of gp96-chaperoned peptides (CD91) and intracellular activation of ER-stress pathways PMID: 25693689
32. PAI-1 can promote cell migration via LRP1-dependent activation of the beta-catenin and ERK1/2 MAPK pathway PMID: 25694133
33. Macrophage LRP may not be necessary for IFN-gamma responses, it can contribute to invariant natural killer T cell activation by enhancing early IL-4 secretion. PMID: 25050824
34. macLRP1-/- mice displayed elevated plasma cholesterol and triglyceride levels resulting from accumulation of large, triglyceride-rich lipoprotein particles in the circulation PMID: 26061292
35. Lrp1-antisense directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1. PMID: 25937287
36. Certain VWD-type 2B mutations relieve the need for shear stress to induce LRP1 binding. Enhanced LRP1 binding coincides with a reduced survival of VWF/p.R1306Q and VWF/p.V1316M PMID: 25728415
37. we have consistently detected lower ApoE levels in young and aged huApoE4 TR mouse brain, and this was associated with reduced expression of the ApoE receptor, LRP1 and NR2A-Y1246 phosphorylation PMID: 25301084
38. TIMP-1 is a ligand of LRP-1 and we highlight a new example of its MMP-independent, cytokine-like functions. PMID: 25075518
39. Results show that LRP1 interacts with and controls the cellular distribution, turnover and phosphorylation of GluA1, which in turn influences calcium influx, neurite outgrowth and filopodia formation in neurons. PMID: 25500815
40. LRP1 deficiency in conditional knock-out mice resulted in glucose intolerance in the brain and hyperglycemia suppresses LRP1 expression. PMID: 25855193
41. Results suggest that in hypothyroidism, decreased expression of hepatic LRP1 may be associated with reduced clearance of circulating remnant lipoproteins. PMID: 23517243
42. This study demonstrated that FVIIIa interacts with Low-density lipoprotein receptor-related protein 1 cluster III. PMID: 25486042
43. Study shows that the levels of hippocampal ApoE receptors Lrp1 and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent PMID: 24251389
44. Angiotensin II infusion in LRP1(-/-) mice exacerbated superior mesenteric artery and ascending aorta dilation. PMID: 25395615
45. The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. PMID: 25377550
46. Using targeted genetic disruption of the interaction between HSPs and CD91, study demonstrated that specific ablation of CD91 in antigen-presenting cells prevented the establishment of antitumor immunity. PMID: 24778318
47. Data indicate that plasminogen activator inhibitor type-1 (PAI-1)-mediated migration of CpG-ODN-stimulated macrophages is low-density lipoprotein receptor-related protein 1 (LRP1)-independent. PMID: 24440681
48. Results demonstrate that LRP-1 affects macrophage polarization and promotes the development of an anti-inflammatory M2 functional phenotype. PMID: 23963646
49. smooth muscle cell Lrp1 deficiency results in aortic dilation and insufficiency that causes secondary cardiomyopathy that can be improved by captopril PMID: 24312398
50. LRP1-deficient cells are not able to take up TpeL and are not intoxicated. PMID: 24737893

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KEGG: mmu:16971

STRING: 10090.ENSMUSP00000044004

UniGene: Mm.271854