Recombinant Mouse Protein unc-93 homolog B1 (Unc93b1), partial

1. autoantibody production in systemic mercury-induced autoimmunity was dependent on the endosomal TLR transporter UNC93B1 PMID: 29055005
2. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3/7/9 in macrophages; macrophages deficient for Tlr3/7/9, Unc93b1, or MyD88 fail to undergo L. major-induced autophagy. (TLR = Toll-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 = myeloid differentiation primary response gene 88) PMID: 28607148
3. Describe a mechanism for differential sorting of endosomal toll like receptors by UNC93B1. PMID: 23426999
4. These observations establish a significant role for Unc93b1 in the regulation of the host inflammatory response to CVB3 infection and also reveal potential mediators of host tissue damage that merit further investigation in acute viral myocarditis. PMID: 25675947
5. Unc93b1 controls activation of both myeloid and lymphoid cells during the innate immune response to influenza. PMID: 24848930
6. The observations demonstrate for the first time that activation of interferon and estrogen signaling in immune cells up-regulates the expression of murine Unc93b1. PMID: 23728775
7. Mutation of the acidic residues in TLR3 and TLR9 prevents UNC93B1 binding, and impairs TLR trafficking and renders the mutant receptors incapable of transmitting signals; therefore, the acidic residues in the juxtamembrane region of the nucleotide-sensing TLRs have important functional roles PMID: 23585677
8. Data indicate that UNC93B1 mutant and triple TLR3/7/9 knock-out mice are highly susceptible to infection with Leishmania major. PMID: 23325805
9. UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection. PMID: 22723955
10. UNC93B, but not Toll-like receptors 3, 7, and 9, is required for bacterial RNA-induced IL-1beta production and activation of caspase-1. PMID: 22634614
11. restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking PMID: 21683627
12. association with UNC93B1 and the intracellular localization of TLRs are not unique features of nucleic acid-sensing TLRs but is also essential for TLR11-dependent recognition of T. gondii profilin and for host protection against this parasite. PMID: 21097503
13. our results reveal a critical role for UNC93B1 on induction of IL-12/IFNgamma production as well as autonomous control of Toxoplasma replication by macrophages. PMID: 20865117
14. identified 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 PMID: 16415873
15. Study shows that UNC93B specifically interacts with TLR3, 7, 9, and 13, whereas introduction of the point mutation H412R in UNC93B abolishes their interactions. PMID: 17452530
16. the function of the polytopic membrane protein UNC93B1 is to deliver the nucleotide-sensing receptors TLR7 and TLR9 from the ER to endolysosomes PMID: 18305481
17. Data suggest that the Toll-like receptor 7/9 response to nucleic acids in dendritic cells is biased toward DNA-sensing by Unc93B1. PMID: 19451267

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KEGG: mmu:54445

STRING: 10090.ENSMUSP00000124272

UniGene: Mm.262094