Recombinant Mouse Pulmonary surfactant-associated protein D (Sftpd)

1. Colitis caused a notable increase in Sftpd gene expression in the gallbladder, but not in the lung, via the activity of glucocorticoids produced in the liver. PMID: 28878025
2. SP-D deficiency reduces atherosclerosis in ApoE-knockout mice by decreasing the accumulation and proliferation of macrophages and by reducing IL-6 levels systemically. PMID: 28472244
3. Our data may promote further studies on the morphological development of the aging lung and the role of SP-D in this process. PMID: 28185902
4. The experimentally induced alterations were more severe in the SP-D(-/-) than in the WT mice, particularly with respect to the surfactant-storing lamellar bodies which were sometimes extremely enlarged in SP-D(-/-) mice. PMID: 27565967
5. these results demonstrate SP-D plays protective roles by inhibiting apoptosis and modulating NF-kappaB-mediated inflammation in CLP-induced acute pancreatic injury . PMID: 26634656
6. our results demonstrate that SFTPD deficiency affects female fertility, highlighting roles for SFTPD in ovarian and uterine physiology PMID: 26874827
7. the collectin Surfactant Protein D is an essential component of host innate immunity to helminths PMID: 26900854
8. SP-D protects the ocular surface from S. aureus infection. PMID: 26398197
9. Estrogen positively regulates expression of SP-D in the mouse uterus. Progesterone, along with estrogen synergizes SP-D expression, however, when administered alone results in negative regulation. PMID: 25693975
10. NOS2 mediates remodeling of septal walls, resulting in deposition of interstitial tissue in Sftpd(-/-). PMID: 26320150
11. Suggest a protective role for SP-D in the pathogenesis of sub-epithelial fibrosis in a mouse model of allergic inflammation through regulation of eosinophil-derived TGF-beta1. PMID: 25472740
12. Data indicate that although iNOS is involved in radiation-induced injury and altered SP-D structure, in the absence of SP-D, it functions to promote proinflammatory signaling. PMID: 25552309
13. No effect of ablation of surfactant protein-D on acute cerebral infarction in mice. PMID: 25038795
14. These results establish that DPPI is a major determinant of survival following Klebsiella pneumoniae lung infection and suggest that the survival disadvantage in DPPI(+/+) mice is in part due to processing of surfactant protein D by DPPI. PMID: 24955853
15. Together, these studies support the conclusion that surfactant protein D increases susceptibility to Cryptococcus neoformans infection by promoting Cryptococcus neoformans-driven pulmonary IL-5 and eosinophil infiltration. PMID: 24478083
16. Sp-D was identified as the ligand of Ig-Hepta/GPR116. PMID: 23922714
17. Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. PMID: 23762428
18. Serum levels of SP-D increase during lung injury, with a sustained increment during chronic inflammation compared with acute inflammation. PMID: 23435873
19. SP-D participates in host defense against the vaccinia virus infection by interaction with the viral surface protein A27. PMID: 23518578
20. SP-D can protect the bladder urothelium against UPEC infection and suggest a possible function of SP-D in urinary tract. PMID: 23012359
21. Mice lacking SP-D were partially protected during Cryptococcus neoformans infection; they displayed a longer mean time to death and decreased fungal burden at several time points postinfection than wild-type mice. PMID: 22547543
22. The data suggest SP-D as a regulator of energy intake and body composition and an inhibitor of metabolic endotoxemia. SP-D may play a causal role at the crossroads of inflammation, obesity, and insulin resistance. PMID: 22509382
23. Inflammation is initiated from abnormal alveolar epithelial cells in Hermansky-Pudlak syndrome, and S-nitrosylated SP-D plays significant role in amplifying pulmonary inflammation. PMID: 21616998
24. a unique biological relevance for SP-D-DNA interactions and places SP-D as an important innate immune protein that promotes bacterial trapping by NETs during neutrophil-mediated host defense. PMID: 21724991
25. SP-D inhibits pulmonary inflammation and migration of peripheral monocyte/macrophages into the lung through GM-CSF-dependent pathways during indirect lung injury PMID: 20639460
26. Viruses expressing the hemagglutinin of pandemic influenza A viruses were associated with significant pathology in the lower respiratory tract, including acute inflammation, and showed low binding activity for lung surfactant protein D. PMID: 21334038
27. SP-D decreases allergen responses, an effect that may be mediated by increase of CTLA4 in T cells. PMID: 20435925
28. Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein PMID: 11956209
29. Results suggest that SP-D-dependent processes regulating surfactant lipid homeostasis were disassociated from those mediating emphysema. PMID: 12163500
30. SP-D-deficient mice have an up to 10-fold increase in the number of apoptotic and necrotic alveolar macrophages with excess surfactant phospholipid accumulation that is reversible by intrapulmonary administration of a fragment of recombinant SP-D. PMID: 12218102
31. SP-D binds to apoptotic cells in a localized, patchy pattern, drives apoptotic cell ingestion by phagocytes through a mechanism dependent on calreticulin and CD91, and alters apoptotic cell clearance from the naive lung. PMID: 12244199
32. CRP-ductin binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. PMID: 12884308
33. Surfactant-associated protein D plays a role in host defense against Pneumocystis carinii in vivo by modulating clearance of organisms, lung inflammation, and metabolism of NO. PMID: 15073692
34. surfactant protein D gene transcription is regulated by NFAT and thyroid transcription factor-1 PMID: 15173172
35. local cytokine release is regulated by SP-D when the (IAV) Influenza A virus is glycosylated at a specific site (N165) suggesting a role in protection from IAV infection. PMID: 15280465
36. GM-CSF-dependent macrophage activity is not necessary for emphysema development in SP-D-deficient mice PMID: 15310555
37. SP-D regulates uptake and catabolism by type II cells and influences the ultrastructure of surfactant in the alveolus. PMID: 15579631
38. SP-D influences innate host defense, in part, by regulating sCD14 in a process mediated by MMP-9 and MMP-12. PMID: 15814723
39. Sp-D has an important role in the regulation of cytokine milieu and eosinophilia in the lungs, and its absence highlights its essential role in host defense against pulmonary allergenic challenge. PMID: 15905537
40. SP-D can bind free DNA and DNA present on apoptotic and necrotic cells, enhance their phagocytosis, and minimize autoantibody generation. PMID: 15905582
41. serum SP-D can serve as a biomarker of lung inflammation in both acute and chronic lung injury in mice PMID: 15967375
42. Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood. PMID: 16255775
43. The ligand binding of homologous human, rat, and mouse trimeric trimeric neck plus carbohydrate recognition domain (neck+CRD) fusion proteins, each with identical N-terminal tags remote from the ligand-binding surface, was compared. PMID: 16514117
44. allergen exposure induces elevation in SP-D protein levels in an interleukin-4/interleukin-13-dependent manner, which in turn, prevents further activation of sensitized T cells PMID: 16517724
45. collagen domain of SP-D is required for the regulation of pulmonary macrophage activation, airspace remodeling, and surfactant lipid homeostasis PMID: 16787926
46. Our data suggest that SP-D in BALF binds beta-glucan on Blastomyces dermatitidis, blocking alveolar macropahges access to beta-glucan, thereby inhibiting TNF-alpha production. PMID: 16861641
47. SP-D regulates surface CD11b and CD11c levels on the alveolar macrophage by modulating receptor trafficking, providing a mechanism by which SP-D mediates phagocytic activity in the alveolar macrophage. PMID: 17056703
48. The in vitro expression of SP-D gene in A549 cells prolonged cell survival following exposure to cigarette smoke condensate. PMID: 17298450
49. Data are suggestive that SP-D may play a role in innate immunity in the female reproductive tract in vivo. PMID: 17954522
50. Important in ocular host defense. Interference with the action of or a deficiency in SPD, even transiently, could predispose the eye to Pseudomonas keratitis. PMID: 17972221

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KEGG: mmu:20390

STRING: 10090.ENSMUSP00000076383

UniGene: Mm.1321