Recombinant Mouse RNA-binding protein Musashi homolog 1 (Msi1)

1. Msi1 has two RNA-binding domains. PMID: 28753936
2. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA. PMID: 29228137
3. Msi proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell. PMID: 27799368
4. photoreceptors lack prototypical neuronal splicing factors and their splicing profile is driven to a significant degree by the Musashi 1 (MSI1) protein. A striking feature of the photoreceptor splicing program are exons that display a "switch-like" pattern of high inclusion levels in photoreceptors and near complete exclusion outside of the retina. PMID: 27541351
5. Given that deregulated fatty acid metabolism plays a key role in kidney fibrosis, these results demonstrate a novel connection between fatty acid and Msi1, an RNA-binding protein, in kidney fibrosis PMID: 27129280
6. A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness. PMID: 26303183
7. studies highlight Msi reporters as a unique tool to identify therapy resistance, and define Msi signalling as a central regulator of pancreatic cancer PMID: 27281208
8. the RNA-binding protein Musashi 1 competes with miR130a and -206 for interaction with tachykinin mRNA PMID: 26373800
9. MSI1 and MSI2 display distinct expression profiles during mammalian folliculogenesis and that MSI2 is required for pre-antral follicle development PMID: 26131972
10. Osteoarticular expression of Msi1 protein is increased in joints with CIA-induced lesion and absent in nonlesioned joints, suggesting that this protein is expressed when the lesion is produced in order to favor tissue repair. PMID: 26064941
11. Msi1 is critical for constructing functional blood-testis barrier &maintaining spermatogenesis. Msi1 regulates Sertoli cell fate following heat-induced injury, likely through induction of stress granule formation & activation of p-ERK1/2 signaling PMID: 25717188
12. Through expression studies and utilizing a transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation. PMID: 25782991
13. Msi proteins contribute to an epithelial gene expression program in neural and mammary cell types. PMID: 25380226
14. MSI1 is specifically inhibited by 18-22 carbon omega-9 monounsaturated fatty acids; MSI1 regulates stearoyl-CoA desaturase PMID: 24935936
15. This study suggests that ciliogenic Rfx transcription factors regulate Msi1 expression in neural stem/progenitor cells. PMID: 25058468
16. Musashi1 binds to the Musashi binding element and that this element is required for polyadenylation in oocytes. PMID: 24586322
17. Msi1-dependent post-transcriptional enhancement of m-Numb is crucial in gastric epithelial regeneration. PMID: 23308249
18. RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways. PMID: 22428049
19. data show that ectopic MSI1 expression may contribute to tumorigenesis in selected bladder cancers through multiple mechanisms and reveal a previously unrecognized function of Musashi1 in the regulation of SG formation PMID: 20477901
20. A regulatory element for Msi1 transcription in neural stem/progenitor cells is located in the sixth intron of the Msi1 gene. PMID: 21486496
21. These data provide evidence that nuclear, and cytoplasmic sequestering of Musashi-1 in retinal cells is context-specific, and may contribute to downstream functioning of Musashi-1. PMID: 21320487
22. Musash1 and Hes1 high expression cells locate predominantly in impaired small-intestinal epithelium after transplantation and contribute to epithelial regeneration. PMID: 21221806
23. Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation. PMID: 21378162
24. overexpression induces tumorigenesis through Wnt and Notch activation PMID: 20826465
25. The Msi1-positive cells can differentiate into neural and intestinal epithelial-like cells in vivo. PMID: 20670215
26. Msi1-mediated posttranscriptional regulation of Robo3 controls midline crossing of precerebellar neurons. PMID: 20696379
27. Positional specification in a neural stem cell line gene expression is modulated by the RNA-binding protein Musashi1 PMID: 19645571
28. Msi1-expression is induced after brain ischemia and may be involved in the reactivation of astrocytes, including their proliferation. PMID: 20036290
29. Expression of the Msi1 and Hes1 small intestinal stem cell markers in the small intestine was not homogenous and the markers were more highly expressed in jejunal tissues. PMID: 20110912
30. Musashi-1 is present in a few epithelial cells just above the Paneth cells in the small intestinal crypt; Musashi-1 and Hes1 were coexpressed in the crypt base columnar cells located between the Paneth cells PMID: 12560091
31. Distribution of Musashi-1-positive cells corresponded with that of stem cells, as outlined in previous reports, implying that Musashi-1 is a key control element of asymmetrical division within the colon crypt. PMID: 12924647
32. Msi1 immunostaining was found in a variety of supporting cells but not in outer hair cells in the organ of Corti. Although an immunoreactive ring was found around the inner hair cells, it also seemed to originate from the supporting cells. PMID: 14700731
33. By immunohistochemistry and RT-PCR, researchers demonstrate for the first time the expression of Musashi1 during development of the inner ear. PMID: 15076722
34. Important for digestive organ development, particularly for epithelial differentiation. PMID: 16287482
35. It is proposed that ELAV RNA-binding proteins exert an important post-transcriptional control on Msi1 expression in the transition from proliferation to neural differentiation of stem/progenitor cells. PMID: 16554442
36. the complementary expression patterns of the murine Msi paralogues Msi1 and Msi2 during spermatogenesis support the idea of distinct, evolutionarily conserved roles of Msi PMID: 16717192
37. The RNA-binding protein, Msi1, is produced in mouse eyes from embryonic stages until adulthood. PMID: 17768378
38. Msi1 regulates oligodendrocyte lineage cell differentiation and survival. PMID: 18098125
39. These results identify Msi1 as a key determinant of the mammary lineage through its ability to coordinate cell cycle entry and activate the Notch and Wnt pathways by a novel autocrine process involving PLF1 and DKK3. PMID: 18362162
40. Msi-1 involved in cancer cell proliferation, inhibition of apoptosis, and mitotic catastrophe, suggesting an important potential mechanism for its role in tumorigenesis. PMID: 18471519
41. Poly(A) binding protein (PABP) is identified as an Msi1-binding protein, and Msi1 competes with eIF4G for PABP binding. PMID: 18490513
42. Data show that doublecortin (dcx) mRNA is a specific binding target of Musashi1 in vitro. PMID: 19573529

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KEGG: mmu:17690

STRING: 10090.ENSMUSP00000120516

UniGene: Mm.391995