Recombinant Mouse Recombining binding protein suppressor of hairless (Rbpj)

1. homoeostatic repressor of multiple pro-angiogenic and angiostatic factor genes in cardiomyocytes PMID: 27357444
2. Early pancreatic islet fate and maturation is controlled through RBP-Jkappa. PMID: 27240887
3. In this study, the authors found that conditional disruption of RBP-J, the transcription factor of canonical Notch signaling, increased irradiation sensitivity in mice. PMID: 27188577
4. Macrophage maturation is controlled by Notch ligand Dll1 expressed in vascular endothelial cells of arteries and requires macrophage canonical Notch signaling via Rbpj, which simultaneously suppresses an inflammatory macrophage fate. Conversely, conditional mutant mice lacking Dll1 or Rbpj show proliferation and transient accumulation of inflammatory macrophages, which antagonizes arteriogenesis and tissue repair. PMID: 29038527
5. RBPJ binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 production in Th17 cells. PMID: 27346359
6. RBP-J deficiency drastically reduced dopamine release in the striatum and caused a subtle decrease in the number of dopaminergic neurons. These findings demonstrated that Notch/RBP-J signaling regulates dopamine responsiveness in the striatum, which may explain the mechanism whereby Notch/RBP-J signaling affects an individual's susceptibility to neuropsychiatric disease. PMID: 28267151
7. RBP-J-mediated Notch signalling is critical for basophil-dependent immunoregulation. Deficiency of RBP-J influences the immunoregulatory functions of BA, which include activation of T cells and their differentiation into T helper cell subtypes. PMID: 28493549
8. study uncovered a regulatory network, where miR-182 functions as an important new node that receives inputs from RBP-J and TNF-alpha signaling and positively regulates inflammatory osteoclastogenesis; suppression of miR-182 by RBP-J serves as an important mechanism that restrains TNF-alpha induced osteoclastogenesis PMID: 27183593
9. structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J. PMID: 28487372
10. RBP-J mediated by miR-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma PMID: 27794430
11. Rbpj-kappa mediated Notch signaling plays a critical role in development of hypothalamic Kisspeptin neurons. PMID: 26318021
12. Results reveal an essential role for canonical Notch/RBP-J signaling in hippocampal synaptic plasticity and suggest that role, at least in part, is mediated by the regulation of GABAergic signaling PMID: 25515406
13. The bone marrow contains a progenitor that expresses renin throughout development and possesses a B-lymphocyte pedigree. This cell requires RBP-J to differentiate. PMID: 24549417
14. functions as a transcriptional repressor on the promoter of the microRNA miR-155 PMID: 24996169
15. DNA methylation-dependent binding of RBPJ to a GC repressor element can negatively regulate smooth muscl myosin heavy chain promoter activity and can inhibit marker gene expression in phenotypically modulated cells PMID: 25324571
16. Rbpj directly regulates the expression of uterine matrix metalloproteinase in a Notch pathway-dependent manner, which is required for normal post-implantation decidual remodeling. PMID: 24971735
17. RBP-J maintains the identity of the renin cell by not only activating genes characteristic of the myo-endocrine phenotype but also, preventing ectopic gene expression and adoption of an aberrant phenotype PMID: 24904090
18. RBP-J-mediated Notch signaling is required for macrophages to promote hepatic fibrosis by up-regulation of NF-kappaB activation through CYLD. PMID: 25145286
19. Environmental cues that regulate RBP-J expression/function potentially modulate the requirement for costimulatory signaling for osteoclast differentiation and bone remodeling. PMID: 25329696
20. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. PMID: 25406395
21. Rbpj is required in postnatal endothelial cells to maintain proper artery, capillary and vein organization and to prevent abnormal arteriovenous shunting and malformation pathogenesis. PMID: 25209249
22. we found that a fraction of RBPJ occupancy sites shifted between interphase and mitosis, suggesting that RBPJ can be retained on mitotic chromatin by sliding on DNA rather than disengaging from chromatin during mitotic chromatin condensation PMID: 24603501
23. The CSL-KyoT2 corepressor complex is a negative regulator of Notch signaling. PMID: 24290140
24. Disruption of the transcription factor RBP-J results in osteopenia attributable to attenuated osteoclast differentiation. PMID: 23224519
25. RBP-J is essential for proper formation and maintenance of the kidney vasculature and glomeruli PMID: 24226518
26. RBP-Jkappa-dependent Notch signaling is required for murine articular cartilage and joint maintenance. PMID: 23839930
27. Data indicate the function of Rbpj is diversified and context dependent in the gliogenesis of somatosensory ganglia. PMID: 23826407
28. Notch/Rbpjkappa signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons, which contribute to homeostatic regulation of body size. PMID: 23884446
29. Notch negatively regulates chondrocyte differentiation in the axial skeleton by suppressing Sox9 transcription, and Rbpj-independent Notch signaling mechanisms may also contribute to axial skeletogenesis PMID: 22991339
30. demonstrate dynamic binding of RBPJ in response to Notch activation at essentially all sites co-occupied by NICD PMID: 23651858
31. RBP-J deficient dendritic cells exhibit attenuated cytoskeleton reorganization when contacting T cells. PMID: 23138187
32. Data found that loss of RBPj in mature excitatory neurons was well tolerated, with no evidence for neurodegeneration or of learning and memory impairment in mice aged up to 18 months. PMID: 23110206
33. Based on the transgenic mouse model, our data indicate that MZ B cells with certain BCR specificity can develop in a Notch-RBP-J independent manner PMID: 22719978
34. The results defined a signaling network in which signaling via Notch-RBP-J and TLRs is integrated at the level of IRF8 synthesis. A mechanism was identified by which heterologous signaling pathways can regulate TLR-induced polarization of macrophages. PMID: 22610140
35. Mice carrying a mesenchymal-specific deletion of CSL/RBP-Jkappa, a key Notch effector, exhibit spontaneous multifocal keratinocyte tumors that develop after dermal atrophy and inflammation. PMID: 22682244
36. RBP-J-mediated Notch signaling in aortic valves may be critically involved in valve homeostasis and valve diseases as well. PMID: 21773950
37. Mice harboring intestinal epithelial cell-specific deletion of Rbpj, a transcription factor that mediates signaling through Notch receptors, develop chronic colitis characterized by the accumulation of T helper (Th)17 cells in colonic lamina propria. PMID: 22279105
38. data demonstrate that Notch regulation of chondrocyte maturation is solely mediated via the RBPj-kappa-dependent pathway, and the perichodrium or osteogenic lineage probably influences chondrocyte terminal maturation and turnover of the cartilage matrix PMID: 22354840
39. RBP-J strongly suppresses tumor necrosis factor-induced osteoclastogenesis and inflammatory bone resorption, but has minimal effects on physiological bone remodeling. PMID: 22249448
40. When HNF-6 loss is combined with RBP-J loss, a phenotype consisting of cholestasis, hepatic necrosis, and fibrosis is observed that is more severe than the phenotype seen with Notch signaling loss alone. PMID: 21898486
41. The data of this study indicated that Rbpj-mediated canonical Notch signaling inhibits DRG neuronal differentiation. PMID: 21510873
42. differentiating hair cells and supporting cells rapidly die in RBPjkappa mutants, suggesting a requirement of RBPjk for cell survival in this tissue. PMID: 21632926
43. Notch signaling disruption via RBPJk heterozygous inactivation results in aortic valve disease. PMID: 21493891
44. Study shows a novel RBP-J function that promotes INP differentiation. PMID: 21443869
45. MINT forms a high affinity complex with CSL; the domains of MINT and CSL that are necessary and sufficient for complex formation are delineated PMID: 21372128
46. roles for Rbpj and notch signaling in multiple aspects of inner ear development including prosensory cell maturation, cellular differentiation and survival PMID: 21420948
47. RBP-J-mediated canonical Notch signaling governs retinal cell specification and differentiation, and maintains retinal lamination through the expression of beta-catenin. PMID: 20017954
48. reduction in graft survival was associated with augmented alloantigen specific T-cell proliferation and increased number of Th1, Th2, and Th17 cells in the RBP-J deficient recipient mice PMID: 21168915
49. This study suggested RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer PMID: 20950430
50. Repression of p53 by RBP-Jkappa and activation of p53 by C/EBPbeta through differential binding of these two factors indicates a type of co-operative regulation in p53 expression. PMID: 20446924

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KEGG: mmu:19664

STRING: 10090.ENSMUSP00000040694

UniGene: Mm.209292