Recombining binding protein suppressor of hairless is a protein in humans that is encoded by RBPJ gene. Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen)
The following RBPJ reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RBPJ Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019486GA01HU | RBPJ Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA019486LA01HU | RBPJ Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA019486LB01HU | RBPJ Antibody, HRP conjugated |
Human | ELISA |
CSB-PA019486LC01HU | RBPJ Antibody, FITC conjugated |
Human | |
CSB-PA019486LD01HU | RBPJ Antibody, Biotin conjugated |
Human | ELISA |
RBPJ Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP019486MO CSB-EP019486MO CSB-BP019486MO CSB-MP019486MO CSB-EP019486MO-B |
Recombinant Mouse Recombining binding protein suppressor of hairless (Rbpj) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RBPJ Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP664862BO CSB-EP664862BO CSB-BP664862BO CSB-MP664862BO CSB-EP664862BO-B |
Recombinant Bovine Recombining binding protein suppressor of hairless (RBPJ) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RBPJ Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP725470PYX CSB-EP725470PYX CSB-BP725470PYX CSB-MP725470PYX CSB-EP725470PYX-B |
Recombinant Pongo abelii Recombining binding protein suppressor of hairless (RBPJ) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RBPJ Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP835525XBE CSB-EP835525XBE CSB-BP835525XBE CSB-MP835525XBE CSB-EP835525XBE-B |
Recombinant Xenopus laevis Suppressor of hairless protein homolog (rbpj), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |