Recombinant Mouse Regulator of G-protein signaling 16 (Rgs16)

1. This study reveals how RGS proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking. PMID: 28235863
2. Findings indicate that regulator of G-protein signaling 16 (RGS16) plays an important role in platelet function by modulating CXCL12-dependent platelet activation. PMID: 26628381
3. RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-mediated pulmonary inflammation. PMID: 22593615
4. Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm. PMID: 21610730
5. RGS16 provides a signaling mechanism for glucose production to inhibit GPCR-stimulated fatty acid oxidation in hepatocytes PMID: 21357625
6. The present study suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s). PMID: 21408016
7. Rgs16 and Rgs8 are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults. PMID: 20616094
8. results suggest that the amino-terminal palmitoylation of regulator of G-protein signaling 16 protein(RGS16) promotes its lipid raft targeting that allows palmitoylation of a poorly accessible cysteine residue PMID: 12642593
9. RGS16 expression in T lymphocytes results in selective blockade of T cell migration to certain chemokines and enhancement of T cell cytokine synthesis in response to a complex inflammatory stimulus. PMID: 12874248
10. Rgs16 was found to change rhythmically in hypothalamic and extra-hypothalamic brain regions reaching peak levels early in the light phase. PMID: 16517089
11. Regulator of G Signaling 16 has a role in the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency PMID: 17635928
12. data show that most likely ET(B)- and S1P1-receptors induce RGS16 protein expression in cardiac myocytes by increasing the transcriptional activity of the rgs16 gene PMID: 18046543
13. The 2.9 A crystal structure of the enigmatic, neuronal G protein Galpha(o) in the GTP hydrolytic transition state, complexed with RGS16.[Galphao] PMID: 18434540
14. Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13. PMID: 18625716
15. cytoplasm, GTPase activator, signal transduction and G-protein coupled receptor protein signaling pathway PMID: 9223279

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KEGG: mmu:19734

STRING: 10090.ENSMUSP00000027748

UniGene: Mm.181709