Recombinant Mouse Retinoic acid-induced protein 1 (Rai1), partial

Product Details

Purity

≥85% (SDS-PAGE)

Target Names

Rai1

Uniprot No.

Q61818

Alternative Names

Rai1; Kiaa1820; Retinoic acid-induced protein 1

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation.

Gene References into Functions

Haploinsufficiency of Retinoic Acid Induced 1 causes Smith-Magenis syndrome. PMID: 30275311
Rai1 preferentially occupies DNA regions near active promoters and promotes the expression of a group of genes involved in circuit assembly and neuronal communication. Behavioral analyses demonstrated that pan-neural loss of Rai1 causes deficits in motor function, learning, and food intake. PMID: 27693255
Mice haploinsufficient for Rai1 fed a high carbohydrate or a high fat diet gained weight at a significantly faster rate than their wild type littermates. PMID: 25127133
Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. PMID: 25752576
Rai1 dosage in forebrain neurons is critical during the development and is related to body weight regulation, activity levels and learning and memory. PMID: 24218365
Rai1 is likely one of the main genes responsible for the circadian clock regulation PMID: 23703963
The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development. PMID: 23345394
RAI1 is a positive transcriptional regulator of CLOCK, pinpointing a novel and important role for this gene in the circadian oscillator PMID: 22578325
study provides evidence to show that Rai1 haploinsufficiency affects feeding, satiety and fat deposition patterns; RAI1 directly regulates the expression of BDNF PMID: 20663924
transcriptional regulator, deficiency is responsible for obesity and craniofacial phenotypes in mice with SMS deletions PMID: 15746153
Activation of the host response by RIG-I early in infection is important for controlling replication of West Nile virus NY PMID: 16501100
Normal disomic Rai1 gene dosage was sufficient to rescue the complex physical and behavioral phenotypes observed in Dp(11)17/+ mice PMID: 17024248
Genomic interval surrounding Rai1 are the major modifying genetic element(s) affecting the craniofacial penetrance PMID: 17273973
Rai1 is a critical gene in the central nervous system functioning in a dosage sensitive manner and that the neurobehavioral phenotype is modified by regulator(s) in the approximately 590 kb genomic interval. PMID: 17517686
Rai1 overexpression is associated with mental retardation, growth and developmental delays, and defective neurological and behavioral functions PMID: 18285828
Distorted Mendelian transmission as a function of genetic background in Rai1-haploinsufficient mice is reported. PMID: 19116176
Rai1 played an important role in the serotonin pathway in a dosage-dependent manner. PMID: 19319603

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Subcellular Location

Cytoplasm. Nucleus. Note=In neurons, localized to neurites.

Tissue Specificity

Detected in all tissues examined with strong expression in the thymus and brain. Expressed in epithelial cells involved in organogenesis. No expression was seen in the corpus callosum of the brain.

Database Links

KEGG: mmu:19377

STRING: 10090.ENSMUSP00000070896

UniGene: Mm.296366

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Recombinant Mouse Retinoic acid-induced protein 1 (Rai1), partial

Product Details

Customer Reviews and Q&A

Target Background

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