Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ryr3

Uniprot No.

A2AGL3

Alternative Names

Ryr3Ryanodine receptor 3; RYR-3; RyR3; Brain ryanodine receptor-calcium release channel; Brain-type ryanodine receptor; Type 3 ryanodine receptor

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity.

Gene References into Functions

Deletion of RyanR3 increased hippocampal neuronal network excitability and accelerated Alzheimer disease pathology. PMID: 24476841
Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2+) stores via the type 3 RyR. PMID: 23818952
Silencing of RyR3 expression in 3T3-L1 preadipocytes resulted in up-regulated adiponectin promoter activity, enhanced adiponectin mRNA expression, and more adiponectin protein secreted into the medium. PMID: 23389954
Requirement of functional ryanodine receptor type 3 for astrocyte migration PMID: 11709492
Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3. PMID: 11867448
Duodenal myocytes expressed both type 2 and type 3 ryanodine receptors and were unable to produce calcium sparks. PMID: 14985349
The short isoform of RYR3 controls calcium release through RYR2 in native smooth muscle cells. PMID: 16678258
Physiologically voltage-controlled Ca(2+) sparks thus require a voltage sensor, a master junctional RyR1 channel that provides trigger Ca(2+), and a slave parajunctional RyR3 cohort PMID: 17360329
Kinetic analysis reveals that systemic ablation of RyR3 results in significant changes to the initiation, duration and amplitude of individual Ca2+ sparks in muscle fibers. PMID: 17412417
There is a specialized function of RyR3 in CA1 pyramidal cells in triggering slow afterhyperpolarization currents due to their localization in the apical dendrite. PMID: 17562071
physiological regulation of RYR3 alternative splicing may play an essential role at the end of pregnancy PMID: 17596299
RyR3 is a very potent source of voltage-independent Ca2+ release activity in adult mouse skeletal muscle fibres. PMID: 18006577
Although RyR3 immunostaining appeared in the dendrites of granule cells, more intense RyR3 staining in rolling mice than in controls was uniformly observed throughout all cerebellar lobules PMID: 18313230

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Subcellular Location

Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Sarcoplasmic reticulum.

Protein Families

Ryanodine receptor (TC 1.A.3.1) family, RYR3 subfamily

Tissue Specificity

Detected in hippocampus, cerebellum, striatum, frontal brain cortex and parietal brain cortex. Detected in skeletal muscle, diaphragm muscle and myometrium (at protein level). Detected in egg cells. Detected in heart, diaphragm, stomach, spleen, ovary, te

Database Links

STRING: 10090.ENSMUSP00000089426

UniGene: Mm.436657

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