Product Details

Purity

>85% (SDS-PAGE)

Target Names

Shank2

Uniprot No.

Q80Z38

Alternative Names

Shank2; Cortbp1; Kiaa1022SH3 and multiple ankyrin repeat domains protein 2; Shank2; Cortactin-binding protein 1; CortBP1

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene References into Functions

The results indicate that SHANK2 is crucial for parallel fiber-Purkinje cell long-term potentiation, but not long-term depression. In addition, SHANK2 is important for intrinsic plasticity of neuronal excitability. PMID: 27581745
location memory acquired in a head-fixed virtual environment. Encoding and updating of virtual cued goal location memory was impaired in Shank2-deficient mice that mimic a deletion found in human autistic patients and exhibit impaired spatial learning in a real environment. These results highlight the roles of the dorsal hippocampus and postsynaptic protein complexes in spatial learning and navigation in virtual reality. PMID: 28484738
Shank2 protein is involved in spinal NMDA receptor-mediated pain, and mutations of Shank2 may suppress NMDA-ERK signaling in spinal pain transmission. PMID: 28326932
We found that Shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors, but is not associated with autistic-like social deficits or repetitive behaviors. PMID: 27903723
Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain. PMID: 27145803
trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice PMID: 25981743
Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW} PMID: 25917711
Shank2 appears to be a key molecule regulating epithelial fluid secretion. PMID: 24445315
syndapin I functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2. PMID: 24751538
Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses. PMID: 20800661
Shank2 negatively regulates CFTR and this may play a significant role in maintaining epithelial homeostasis PMID: 14679199
Data suggest that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina. PMID: 19299912

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Subcellular Location

Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cell projection, growth cone.

Protein Families

SHANK family

Tissue Specificity

Detected in brain (at protein level), where it is highly expressed in Purkinje cells.

Database Links

KEGG: mmu:210274

STRING: 10090.ENSMUSP00000095542

UniGene: Mm.483624

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Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 2 (Shank2), partial

Product Details

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Target Background

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