Recombinant Mouse Secreted frizzled-related protein 1(Sfrp1)

Code CSB-YP021138MO
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Source Yeast
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Code CSB-EP021138MO
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Source E.coli
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Code CSB-EP021138MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP021138MO
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Source Baculovirus
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Code CSB-MP021138MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Sfrp1
Uniprot No. Q8C4U3
Alternative Names Sfrp1; Secreted frizzled-related protein 1; sFRP-1
Species Mus musculus (Mouse)
Expression Region 32-314
Target Protein Sequence SEYDYVSFQ SDIGSYQSGR FYTKPPQCVD IPVDLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHMGTQ VFLCSLFAPV CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNTTEASKP QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK KELKRLVLFL KNGADCPCHQ LDNLSHNFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKR MKNHECPTFQ SVFK
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Gene References into Functions
  1. The results of this study indicated that Shh, Sfrp1, and Wnt5a collaborate to direct the pathfinding of descending 5-HT axons in the brainstem PMID: 29196093
  2. Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system. PMID: 28687085
  3. OVOL1-regulated Fst and SFRP1 affect hair inductive potency of neonatal dermal cells. PMID: 25827793
  4. Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice. PMID: 25809273
  5. Study suggests that the induction of the WNT pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process. PMID: 25669938
  6. the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity PMID: 24339864
  7. findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease PMID: 25212222
  8. Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt/PCP pathway in a mouse model of obstructive nephropathy PMID: 25253698
  9. SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer. PMID: 24885183
  10. Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 expression is decreased, and that p53 expression is generally diminished. PMID: 24038862
  11. secreted FRP1 either inhibits or enhances signaling in the Wnt3a/beta-catenin pathway PMID: 24080158
  12. Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis. PMID: 23261541
  13. studies indicate that mutations neither in sFRP1 nor in sFRP4 are a common cause of craniotubular hyperostoses PMID: 23044044
  14. SFRP1 gene is critical for maintaining proper mammary gland development. PMID: 22928951
  15. expression of Pax6 is necessary and sufficient to render postmitotic neurons competent to respond to SFRP1 to increase axonal growth PMID: 22359602
  16. Secreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory response. PMID: 21836067
  17. Data demonstrate that SFRP1 promotes normal alveolar formation in lung development, although its expression in the adult up-regulates proteins that can cause tissue destruction. PMID: 20595636
  18. WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth PMID: 19473496
  19. Overexpression through direct or indirect interaction with different phases of infarct healing, reduced infarct size and improved cardiac function. PMID: 14581414
  20. Deletion of sFRP-1 expression in mice preferentially activates Wnt signaling in osteoblasts, leading to enhanced trabecular bone formation in adults. PMID: 14976225
  21. sFRP-1 is expressed by osteoblasts and inhibits osteoclast formation PMID: 15476588
  22. This study suggests that SFRP1 may be partly responsible for the poorer healing performance of the palatal wounds compared with dermal wounds. Blocking SFRP1 results in improvement of palatal healing outcomes. PMID: 16567562
  23. These studies have identified sFRP1 as a critical negative regulator of Wnt signaling for the normal progression of chondrocyte differentiation. PMID: 16575902
  24. The loss of sFRP-1 and PTH treatment increase vBMD to a similar extent. Moreover, as the effects of sFRP-1 deletion on vBMD increase, the ability of PTH to enhance vBMD declines suggesting that there are overlapping mechanisms of action. PMID: 17044082
  25. DKK1 and SFRP1 inhibit the transformed phenotype of breast cancer cell lines, and DKK1 inhibits tumor formation. PMID: 17485441
  26. may be involved in the development of periodontitis PMID: 17720858
  27. sFRP-1 can interact with Wnt receptors Frizzled 4 and 7 on endothelial cells to transduce downstream to cellular machineries requiring Rac-1 activity in cooperation with GSK-3beta PMID: 18156211
  28. These data demonstrated a previously unrecognized role for Sfrp1 as a stromal-to-epithelial paracrine modulator of epithelial growth, branching morphogenesis, and epithelial gene expression. PMID: 18371946
  29. A potential role of Wnt signaling in denervation was examined by comparing the expression levels of Sfrp1 and key proteins in the canonical Wnt pathway. PMID: 18392598
  30. targeting sFRP1 can be used as a therapeutic strategy for increasing bone mass in metabolic bone disorders or promoting fracture healing PMID: 18498122
  31. Results identified novel expression domains for the Wnt antagonists Sfrp1, Sfrp3, Sfrp5 as well as Dkk2 and Dkk3. PMID: 19185060
  32. Secreted frizzled related protein 1 is a target to improve fracture healing. PMID: 19301255
  33. Sfrp1 is required to maintain HSC homeostasis through extrinsic regulation of beta-catenin. PMID: 19664990

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Subcellular Location Secreted.
Protein Families Secreted frizzled-related protein (sFRP) family
Tissue Specificity Highly expressed in kidney and embryonic heart. Also highly expressed in the eye, where it is principally localized to the ciliary body and the lens epithelium. Weaker expression in heart, lung and brain. In the brain, is expressed exclusively in the chor
Database Links

KEGG: mmu:20377

STRING: 10090.ENSMUSP00000033952

UniGene: Mm.281691

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