Recombinant Mouse Securin (Pttg1)

1. The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss. PMID: 28516917
2. Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation. PMID: 28658604
3. High PTTG1 expression is associated with pituitary tumor development. PMID: 27524416
4. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target. PMID: 25936962
5. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses. PMID: 25421944
6. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons. PMID: 24927528
7. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis PMID: 24395789
8. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function PMID: 21203837
9. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. PMID: 12626748
10. homologue disjunction in mouse oocytes is dependent on proteolysis of the separase inhibitor securin and cyclin B1 PMID: 14593421
11. Physiological functions of PTTG are revealed by PTTG-null mice who exhibit a variety of cell growth abnormalities including diabetes mellitus secondary to defective beta-cell proliferation. Review. PMID: 15281346
12. Securin phosphorylation act redundantly to prevent sister chromatid separation. PMID: 16030258
13. results suggest that Rae1 and Nup98 are temporal regulators of APC(Cdh1) that maintain euploidy by preventing unscheduled degradation of securin PMID: 16355229
14. results suggest that the proteolysis of securin is dependent on ubiquitin-proteasome pathway and is necessary for the degradation of Rec8 during meiotic metaphase-to-anaphase transitions in oocytes PMID: 16720305
15. PTTG1 and its binding protein PTTG binding factor are expressed in pituitary FS TtT/GF cells. PMID: 16959877
16. PTTG1, an oncogene, is regulated by the liganded thyroid hormone receptor beta PMID: 17039256
17. Deregulation of Pttg1 expression is attributable to a cysteine-249-tryptophan substitution in the extracellular domain of crumbs homolog 1 (Crb1). PMID: 17234588
18. Cdc20 and securin double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin in preventing mitotic exit PMID: 17325031
19. Pttg deletion reduces bone marrow stem cell proliferation, renders cells more sensitive to hypoxia, and enhances senescent features, thus pointing to a role for Pttg in the maintenance and proliferation of the cells PMID: 17626243
20. In mouse pituitary tumor cell lines, PTTG was localized in the Golgi apparatus and vesicles. PMID: 17652795
21. Pituitary tumor-transforming gene (Pttg) deletion results in pituitary hypoplasia, low pituitary cell proliferation rates, and rescue of pituitary tumor development in Rb(+/-) mice. PMID: 17975001
22. Data show that in mouse oocytes, excess securin causes stabilization of cyclin B and precocious entry into M-phase. PMID: 18364698
23. GPC1 regulates EC cell cycle progression at least partially by modulating APC/C-mediated degradation of mitotic cyclins and securin PMID: 18417614
24. Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs PMID: 18639540
25. Beta-cell apoptosis and senescence contribute to the diminished beta-cell mass in PTTG(-/-) mice, likely secondary to DNA damage. PMID: 19213844
26. PTTG1 and DLK1 are involved in cell differentiation and transformation. PMID: 19477929

Show More

Hide All

KEGG: mmu:30939

STRING: 10090.ENSMUSP00000020687

UniGene: Mm.6856