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Recombinant Mouse Serine protease inhibitor A3G (Serpina3g)

Recombinant Mouse Serine protease inhibitor A3G (Serpina3g)

Code	CSB-YP683291MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Yeast
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Code	CSB-EP683291MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
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Code	CSB-EP683291MO-B
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP683291MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP683291MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Serpina3g

Uniprot No.

Q5I2A0

Alternative Names

Serine protease inhibitor 2A; Serine protease inhibitor A3G; Serpin 2A; Serpin A3G; Serpina3g; SPA3G_MOUSE

Species

Mus musculus (Mouse)

Expression Region

1-440

Target Protein Sequence

MAGVSPAVFG CPDVTLGRNT AVREVQENVT SVDSLTLVSS NTDFAFSLYR KLVLKNPDEN VVFSPFSICT ALALLSLGAK SNTLKEILEG LKFNLTETPE PDIHQGFRYL LDLLSQPGNQ VQISTGSALF IEKHLQILAE FKEKARALYQ AEAFTADFQQ PLKATKLIND YVSNHTQGKI KELISGLKES TLMVLVNYIY FKGKWKNPFD PNDTFKSEFY LDEKRSVIVS MMKTGYLTTP YFRDEELSCT VVELKYTGNA SAMFILPDQG RMQQVEASLQ PETLRKWKNS LKPRMIHELR LPKFSISTDY SLEHILPELG IREVFSTQAD LSAITGTKDL RVSQVVHKAV LDVAETGTEA AAATGMAGVG CCAVFDFLEI FFNRPFLMII SDTKAHIALF MAKVTNPERS MNFPNGEGAS SQRLESKRLC FGDPLCLIGQ

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Serine and cysteine protease inhibitor. Can inhibit lysosomal papain-like proteases including the cathepsins B, G, H, K, L and V. Ineffective against elastase, granzyme A, granzyme B, or caspases 3, 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells.

Gene References into Functions

Authors define roles for an HP-regulated Serpina3g/Spi2A intracellular serpin during granulomyelocytic, B-cell, and hematopoietic stem cell (HSC) formation. PMID: 24964278
SerpinA3g plays a role in the TNF-alpha modulation of adipose tissue development and metabolism. PMID: 24973688
inhibition of lysosomal executioner proteases by Spi2A is a physiological mechanism by which cells are protected from caspase-independent programmed cell death PMID: 15225607

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Serpin family

Tissue Specificity

Expressed in bone marrow (particularly hematopoietic stem cells), heart, kidney, liver, lung, skeletal muscle, spleen, testis, thymus and T-cells.

Database Links

KEGG: mmu:20715

STRING: 10090.ENSMUSP00000041250

UniGene: Mm.312628

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