Recombinant Mouse Signal transducer and activator of transcription 4 (Stat4)

1. The results show that STAT4 plays a critical role in mediating both Th1 and Th2 responses upon immunization with monophosphoryl lipid A. PMID: 27578456
2. this study shows that STAT4 regulates the CD8(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr(-/-) mice PMID: 29055004
3. virus-specific effector and memory CD4 T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 T cells was apparent in mice lacking both transcription factors. PMID: 24231259
4. expression associated with early Inflammation in diabetic wounds PMID: 28107529
5. STAT4 has a pro-atherogenic role that is at least partially independent of Th1 cell-derived interferon-gamma PMID: 26386214
6. Modulation of IL-12/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes PMID: 26555476
7. This study found that stathmin plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory PMID: 26818507
8. STAT4 controls GM-CSF production by both Th1 and Th17 cells during experimental autoimmune encephalomyelitis. PMID: 26123499
9. Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation. PMID: 26285907
10. T-bet- and STAT4-dependent IL-33 receptor expression have roles in directly promoting antiviral Th1 cell responses PMID: 25829541
11. Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma and CD25 induction through STAT4-independent pathways. PMID: 25336459
12. STAT4 appears to be a critical transcription factor in defense against mycobacterial infection PMID: 12488562
13. STAT4 deficiency protects against neointima formation following arterial injury in mice. PMID: 24933129
14. IL-12 drives small airway remodeling via STAT4 signaling. PMID: 24922586
15. These data demonstrate that STAT4 regulates the respiratory syncytial virus-specific CD8+ T cell response to secondary infection but does not independently regulate lung Th2 or Th17 immune responses. PMID: 24920804
16. STAT4 is dispensable for antimonial-based chemotherapy. PMID: 24242758
17. We have identified STAT4 as a key contributor to insulin resistance and AT inflammation in diet-induced obesity. PMID: 23939393
18. STAT4 deficiency has no conspicuous effect on the development and fecundity of S. japonicum. PMID: 22164377
19. loss of either STAT4 or T-box expressed in T cells increased Ifng promoter CpG methylation in both effector and memory Th2 cells. PMID: 23761633
20. one mechanism for STAT4-dependent gene programming is in establishing a derepressed genetic state susceptible to transactivation by additional fate-determining transcription factors. PMID: 23772023
21. These findings confirm the results of genetics studies on the role of STAT-4 in the development of systemic sclerosis. PMID: 21360510
22. Mice that lacked STAT4 had impaired HSV-2-specific IFN-gamma production and delayed-type hypersensitivity responses. PMID: 22718836
23. CWE was able to down-regulate IFN-gamma expression in activated T cells without altering IL-2 production, involving inhibition of p38, JNK, ERK1/2, and STAT4. PMID: 22053946
24. Our results represent the first evidence that the SDF-1/CXCR4 axis upregualtes myocardial STAT3 activation PMID: 21821779
25. Results highlight the critical role of Stat4 Th1 signals in autoimmune responses in suppressing Foxp3(+) Treg responses and altering the balance between Th17 and Tregs to favor autoimmune disease. PMID: 21525389
26. gamma rays cause a decrease in IFN-gamma, IL-12p70, IL-12 receptor beta2, and STAT4 and an increase in IL-4 in natural killer cells PMID: 21219110
27. Expression of tenascin-C is significantly attenuated in the airways of STAT4-/- mice, which may be due to the impaired secretion of TNF-alpha and IFN-gamma in these mice. PMID: 21205293
28. Circulating IL-18 levels were elevated in Stat4-deficient compared to Stat4-intact mice, suggesting that this interleukin might contribute to the progression of lupus nephritis independent of Stat4. PMID: 20980973
29. The present data suggest that IL-13-mediated asthma phenotypes, such as airway-hyperresponsiveness and non-eosinophilic inflammation, in the Th2 type asthma are dependent on the IL-12-STAT4-IFN-gamma axis. PMID: 20592486
30. STAT4 and STAT6 play wide regulatory roles in T helper cell specification. PMID: 20620946
31. The absence of (T helper) TH1 and elevation of TH2 responses in STAT4-/- mice had no role in protection against ocular herpes simpex virus type 1 infection but did have an effect on immunoglobulin-G (IgG)-subtype switching and early viral replication. PMID: 20104254
32. role in IL-12 induction of T cell CCR5 PMID: 11739505
33. STAT4 up-regulates AP-1-mediated IFN-gamma promoter activation without directly binding to the promoter sequence, providing a mechanistic explanation for IL-12/IL-18-induced synergistic enhancement of IFN-gamma gene expression. PMID: 11801649
34. IFN-alphabeta alone induces tyrosine phosphorylation of STAT4 in murine splenocytes of different mouse strains. PMID: 12165484
35. phosphorylation of STAT4 on both tyrosine and serine residues is important in promoting normal T(H)1 differentiation and IFN-gamma secretion PMID: 12213961
36. demonstrated that IFN-alpha activates STAT4 directly and that this is required for IFN-gamma production during viral infections of mice, in concert with T cell receptor-derived signals PMID: 12242445
37. Activated STAT4 plays an essential downstream role in the early events of IL-12-induced Th1 cell differentiation that is independent of its role in the support of IL-12R beta 2 chain signaling. PMID: 12370372
38. Mucosal Ad-IFN-gamma gene transfer can effectively attenuate established allergen-induced airway inflammation and airway hyperreactivity, predominantly through an IL-12- and STAT4-dependent mechanism. PMID: 12396623
39. STAT4 was not required for the host response during experimental vesicular stomatitis virus encephalitis. PMID: 12458040
40. Role of signal transducer and activator of transcription 4 (Stat4) and Stat6 signaling in liver I/R injury. PMID: 12540779
41. A role is outlined for Stat4 in the development of the local allergic airway response via a mechanism centered on the production of chemokines and enhanced accumulation of appropriate effector cells. PMID: 12646654
42. GATA-3 expression in developing Th1 cells does not block Th1 development in cells coexpressing Stat4 but does so in cells coexpressing T-bet. PMID: 12648458
43. Stat4 may play a role in autoantibody production in lupus-prone New Zealand Mixed 2410 mice that develop a severe glomerulosclerosis and rapidly progressive renal disease. PMID: 12707364
44. mice that were STAT4 deficient are be protected from renal ischemia reperfusion injury PMID: 12709397
45. Stat4-deficient New Zealand mixed 2328 (NZM) mice develop accelerated nephritis and increased mortality in the absence of high levels of autoantibodies including anti-double-stranded DNA Abs, and in the presence of relatively reduced levels of IFN-gamma. PMID: 12874250
46. Naturally occurring alternative splicing forms of Stat4 were isolated (Stat4alpha and Stat4beta); each had distinct requirements in IL-12 responses. PMID: 12912921
47. Stat4 and Stat6 regulate opposing programs of T helper differentiation PMID: 12965077
48. STAT4 has a role in interleukin-12-induced chromatin remodeling of the CD25 locus PMID: 14660657
49. Acetylcholine receptor-specific Th1 cells are nearly absent in wild-type and STAT4-deficient BALB/c mice; these animals are resistant to experimental myasthenia gravis. PMID: 14688314
50. nonphosphorylated STAT4 dimers form in vivo before cytokine receptor-driven activation PMID: 14704793

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KEGG: mmu:20849

STRING: 10090.ENSMUSP00000027277

UniGene: Mm.1550