Recombinant Mouse Solute carrier family 40 member 1 (Slc40a1), partial

1. study indicates that copper is an important player in the regulation of the Slc40a1 gene expression. PMID: 28219768
2. Pulmonary iron overload is associated with oxidative stress, restrictive lung disease with decreased total lung capacity and reduced blood oxygen saturation in homozygous Slc40a1(C326S/C326S) mice compared to wild-type controls. PMID: 28499927
3. ferroportin mRNA downregulation depends on M2 subtype polarization of macrophage PMID: 27667162
4. Fasting upregulates Fpn1 expression in spleen and peritoneal macrophages, probably via a ghrelin/GHSR1a/MAPK signaling pathway. PMID: 28338217
5. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes PMID: 27483296
6. findings show that ferroportin expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle PMID: 27465531
7. these results indicate that Fpn deficiency decreases Mn trafficking out of the brain, alters body Fe, Mn, Zn and Cu levels, and promotes metal accumulation in olfactory bulbs. PMID: 26693922
8. The results suggest that physiologic hepcidin levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells. PMID: 26506980
9. In Angiotensin II treated mice, duodenal divalent metal transporter-1 and ferroportin expression levels were increased and hepatic hepcidin mRNA expression and serum hepcidin concentration were reduced. PMID: 25096756
10. Fpn plays a central role in Mn transport and flatiron (ffe/+) mice provide an excellent genetic model to explore the role of this exporter in Mn homeostasis. PMID: 25782988
11. Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron. PMID: 25824831
12. Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself PMID: 24252754
13. Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption. PMID: 24776745
14. Genetic interactions between Cp, Mon1a, and the Slc40a1 locus are involved in iron metabolism. PMID: 24121729
15. Hypoxia signal, stimulated erythropoietin, which affected iron absorption by stabilizing duodenal ferroportin. PMID: 23656253
16. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. PMID: 23846698
17. The infection of M.tuberculosis can lead to increased Fn expression and decreased FPN expression in macrophages, and the levels of Fn and FPN in the infected macrophages are both related to the strength of the virulence of M.tuberculosis. PMID: 23837981
18. Nitric oxide up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells. PMID: 23630227
19. Ferroportin transcription following experimentally-induced acute anemia in mice is tissue-specific. PMID: 22921471
20. Ferroportin expression is detected in Kupffer cells and is markedly enhanced at the basolateral membrane of the renal tubules of Hmox1-deficient mice. PMID: 22992020
21. CD61 regulates the expression of Slc40a1, which is involved in iron transportation in epithelial tissues. PMID: 23064962
22. in kidney proximal tubules FPN1 is expressed on the basolateral membrane of S1, S2 and S3 segments; under conditions of increased cellular iron, intracellularly expressed FPN1 traffics to the plasma membrane PMID: 20015204
23. Expression levels of TNF-alpha and IL-6 were significantly enhanced in Fpn1(LysM/LysM) macrophages lacking Fpn1. PMID: 21705499
24. HIF-2alpha directly binds to the Fpn promoter and induces its expression, indicating a mechanism of transcriptional regulation of Fpn following changes in systemic levels of iron. PMID: 21419768
25. Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription PMID: 21303654
26. Zinc and cadmium can activate Fpn1 transcription through the Metal Transcription Factor-1. PMID: 20688958
27. show that Fpn1 is not required in the embryo proper but rather in the extra-embryonic visceral endoderm. PMID: 20702562
28. MTP1 is downregulated in the reticuloendothelial system during inflammation PMID: 12161425
29. Hephaestin and Ireg1 expression respond to systemic rather than local signals of iron status. PMID: 12730111
30. GPI-ceruloplasmin colocalizes on the astrocyte cell surface with the divalent metal transporter IREG1 and is physically associated with IREG1. PMID: 12743117
31. The rapid and strong induction of FPN1 expression after erythrophagocytosis suggests that FPN1 plays a role in iron recycling PMID: 12907459
32. The iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system. PMID: 14568251
33. Results show no correlation between the expression levels of the duodenal iron transporters DMT1 and IREG1 and the liver iron content in Hfe (hemochromatosis) knockout mice. PMID: 14618243
34. Copper regulates macrophage iron recycling and induces Fpn1 expression. PMID: 14973193
35. Despite changes in copper and iron status, FPN1 mRNA levels are not altered in duodenum, liver, kidney, and spleen. PMID: 14988440
36. identified decreased Fpn1 expression in placental syncytiotrophoblast cells at late gestation as the mechanism of neonatal iron deficiency in Pcm mutants PMID: 15342464
37. hepcidin bound to ferroportin in tissue culture cells; after binding, ferroportin was internalized and degraded, leading to decreased export of cellular iron PMID: 15514116
38. FPN1 is directly involved in the export of iron during erythrocyte-iron recycling by macrophages. PMID: 15665091
39. Neuronal survival of iron accumulation associates with increased expression of the efflux transporter IREG1. PMID: 15667655
40. Iron absorption genes(Dcytb,IREG1,DMT1)were expressed at lower levels in mouse caecum and colon than in the duodenum. They are regulated by body iron requirements. PMID: 15764147
41. There appear to be both probable transcriptional and post-transcriptional control of FPN1 expression by LPS-induced inflammation. The former effect is on mRNA expression and is independent of hepcidin, whereas the latter is IL-6- and hepcidin-dependent PMID: 15932798
42. hepcidin accumulated in the ferroportin-rich organs, liver, spleen, and proximal duodenum, highlighting the central role of the hepcidin-ferroportin interaction in iron homeostasis PMID: 15933050
43. define the major sites of ferroportin activity PMID: 16054062
44. localization, expression, and regulation of ferroportin in both duodenal and macrophage cells PMID: 16081760
45. dominant inheritance of Fpn-iron overload disease is due to the dominant-negative effects of mutant Fpn proteins PMID: 17077321
46. Mutations in Fpn resulting in protein mislocalization act in a dominant-negative fashion to cause disease, and the Fpn(ffe) mouse represents the first mouse model of ferroportin disease. PMID: 17289807
47. the degree of ineffective erythropoiesis (IE) dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa PMID: 17299088
48. After binding of hepcidin, Fpn is tyrosine phosphorylated at the plasma membrane. PMID: 17475779
49. Suggest that haptoglobin, by controlling plasma levels of hemoglobin, participates in the regulation of ferroportin expression, thus contributing to the regulation of iron transfer from duodenal mucosa to plasma. PMID: 17919498
50. dual mechanism of Fpn regulation in bone-marrow-derived macrophages, characterized by early induction of the gene transcription predominantly mediated by haem, followed by iron-mediated post-transcriptional regulation of the exporter. PMID: 18072938

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KEGG: mmu:53945

STRING: 10090.ENSMUSP00000027137

UniGene: Mm.28756