Recombinant Mouse Src substrate cortactin (Cttn)

1. this paper shows that cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe dextran sulfate sodium-induced colitis PMID: 28120846
2. Secretion of the barrier-stabilising hormone adrenomedullin, which activates Rap1 and counteracts actomyosin contractility, was reduced in plasma from cortactin-deficient mice. Cortactin plays a role in controlling actomyosin contractility with consequences for endothelial barrier integrity. PMID: 27357373
3. AMPK phosphorylation of cortactin followed by SIRT1 deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK/SIRT1 coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase subcellular translocation/activation and is atheroprotective. PMID: 27758765
4. Cortactin may have an important role in the development of oral tumors in mice PMID: 27148699
5. findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses. PMID: 26602019
6. association of cortactin with Pfn-1 is regulated by c-Abl-mediated cortactin phosphorylation PMID: 24700464
7. Cell proliferation, migration and invasion were inhibited by genetic knockdown of EMS1. PMID: 24127012
8. our findings suggest that after GnRHa activation, src activity leads to tyrosine phosphorylation of cortactin, which facilitates its association with Arp3 to engage the actin cytoskeleton. PMID: 24274984
9. GIT1-cortactin association through GIT1-Spa homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis. PMID: 24265417
10. Data indicate that cortactin as an Src-dependent interacting partner of EB1. PMID: 24144981
11. Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin binding of HPK1 peptide. PMID: 22976002
12. mXinalpha together with cortactin is able to modulate the p120-catenin activity for shape change and adhesion at the intercalated discs. PMID: 23296090
13. FAK-mediated focal adhesion remodeling may occur through the formation of a FAK-cortactin signaling complex. PMID: 22952866
14. ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation. PMID: 22952966
15. we demonstrate that cell spreading promotes the association of cortactin and FAK and that tyrosine phosphorylation of cortactin disrupts this interaction, which may explain how it inhibits cell spreading. PMID: 22479425
16. LPS modulation of cortactin stability is coordinately regulated by stress kinases and the ubiquitin-proteasomal network. PMID: 22514278
17. MLCK is essential for the translocation and association of cortactin and p47phox. PMID: 22219181
18. Cortactin is crucial for orchestrating the molecular events leading to proper endothelial barrier function and leukocyte recruitment in vivo. PMID: 21788407
19. data suggest the possibility that localization of the more tyrosine 466-phosphorylated p85 isoform of cortactin around the heads of elongated spermatids is important for stages VII-VIII processes PMID: 20539040
20. Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts. PMID: 20650888
21. Results suggest that MIM promotes ciliogenesis by antagonizing Src-dependent phosphorylation of Cortactin and describe a mechanism linking regulation of the actin cytoskeleton with ciliogenesis and Shh signaling during tissue regeneration. PMID: 20708589
22. Data suggest that cortactin plays an important role in the mechanics of asymmetric division in oocytes. PMID: 20004659
23. These results suggest a novel function of phosphorylation-dependent cortactin signaling. PMID: 20041195
24. Cortactin and connexin 43 (Cx43) were physically linked in seminiferous tubule homogenates and their colocalization in the basal and apical thirds of the seminiferous epithelium was stage-dependent. PMID: 19725064
25. Cortactin-binding protein 90 (CBP90) expression in the mouse mammary glands during prolactin-induced lobuloalveolar development [CBP90] PMID: 12130822
26. phosphorylation of cortactin tyrosine residues in the carboxy terminus requires the aminoterminal domain PMID: 12925758
27. alternative splicing of the F-actin binding domain of cortactin is a new mechanism by which cortactin influences cell migration PMID: 12952985
28. cortactin is a specific substrate and cooperative effector of Fyn in integrin-mediated signaling processes regulating metastatic potential PMID: 13129922
29. Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex PMID: 15169891
30. Cortactin regulates cell movement through activation of N-WASP. PMID: 15585574
31. A short splicing variant of missing in metastasis binds poorly to cortactin in vitro and is unable to enhance actin polymerization. PMID: 15688017
32. Our findings suggest that cortactin plays a role in Listeria internalization, but not in the formation of actin clouds and tails, or in bacteria intracellular motility. PMID: 16489553
33. Cortactin was found to be an early component of the nascent podosome belt, along with dynamin, supporting a role for cortactin in actin assembly. PMID: 16611741
34. electron microscopy and 3D reconstruction were carried out on F-actin decorated with the actin-binding repeating domain of cortactin, revealing conspicuous density on F-actin attributable to cortactin that is located on a consensus-binding site PMID: 16697006
35. The results indicate that the transition from a polygonal to an elongated shape entails the acquisition of a dynamic cortical actin cytoskeleton that involves the tyrosine kinase-dependent phosphorylation of cortactin. PMID: 16733791
36. Targeting of cortactin to BK channels via a novel, noncanonical SH3 domain binding motif has important implications for the coordination of BK channel function in normal physiology and disease PMID: 17065230
37. Formation of functional invadopodia requires interaction between cortactin and filamentous actin. Phosphorylation of cortactin by Src is essential for functional invadopodia formation. PMID: 17343955
38. Results provide novel genetic evidence that a ROS-Fer signaling arm contributes to SFK-mediated cortactin tyrosine phosphorylation in integrin signaling. PMID: 17606629
39. CD44 is an important regulator of HGF/c-Met-mediated in vitro and in vivo barrier enhancement, a process with essential involvement of Tiam1, Rac1, dynamin 2, and cortactin. PMID: 17702746
40. These results are in disagreement with the proposed model of the cortactin molecule and have important implications for our understanding of cortactin regulation of cytoskeleton dynamics. PMID: 19089942
41. Cortactin promotes cell migration indirectly, through contributing to activation of selected Rho-GTPases. PMID: 19458196
42. Depletion of cortactin in mouse embryonic fibroblasts does not profoundly influence actin-dependent cell motility. PMID: 19621352

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KEGG: mmu:13043

STRING: 10090.ENSMUSP00000099368

UniGene: Mm.205601