Product Details

Purity

>85% (SDS-PAGE)

Target Names

Stab2

Uniprot No.

Q8R4U0

Alternative Names

Stab2; Feel2; Hare; Stabilin-2; Fasciclin; EGF-like; laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2) [Cleaved into: Short form stabilin-2]

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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■ Q&A

Mass of the purified protein
Size M/W of the protein expressed

The purity is comprehensively evaluated by SDS-PAGE Coomassie Brilliant Blue staining detection and Bandscan software analysis. Our QC standard of purity for all recombinant proteins is higher than 85% as determined by SDS-PAGE.
At present, the label is determined in production, so the complete sequence of the final protein cannot be determined, that is, the molecular weight of the fusion protein cannot be determined at present.

Target Background

Function

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalization as well as HA and CS.

Gene References into Functions

Stab2 recognizes phospatidylserine exposed on apoptotic cells for sensing as an "eat-me" signal. PMID: 27174501
Results show that Stab2 contributes to phosphatidylserine-dependent myoblast fusion and provide new insights into the molecular mechanism by which phosphatidylserine mediates myoblast fusion during muscle growth and regeneration. PMID: 26972991
A dramatic elevation in circulating hyaluronic acid levels in Stab2-deficient mice without any overt phenotype, is reported. PMID: 22371575
Adrenomedullin treatment from day 14 to day 20 promoted the differentiation of stabilin-2-positive endothelial cells. PMID: 21782867
FEEL-1 and this protein are endocytic receptors for advanced glycation end products. PMID: 12473645
mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses PMID: 14598175
Stabilin-2-mediated aggregation is mediated by homophilic interactions and enhanced in the presence of Ca(2+) and Mg(2+). Interestingly, exogenous addition of FAS1 domains but not EGF-like domains enhances stabilin-2-mediated cell aggregation PMID: 19328203
stabilin-2 contributes to adhesion and homing of circulating stem and progenitor cells to bone marrow. PMID: 19850011

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Subcellular Location

Cytoplasm. Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in endothelial sinuses of liver, lymph nodes, bone marrow, spleen and in specialised structures of eye, heart, brain and kidney. Expression is detected in corneal and lens epithelium, in mesenchymal cells of the heart valves, in the ependymal ce

Database Links

KEGG: mmu:192188

STRING: 10090.ENSMUSP00000048309

UniGene: Mm.279611

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Recombinant Mouse Stabilin-2 (Stab2), partial

Product Details

Customer Reviews and Q&A

Target Background

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