Recombinant Mouse Stimulated by retinoic acid gene 8 protein (Stra8)

1. This study concluded that retinoic acid and STRA8 are conserved factors that control the initiation of meiosis amongst mammals but the role of CYP26B1 as a meiosis-inhibiting factor may be specific to rodents. PMID: 29044428
2. Combined deletion of Mettl3 and Mettl14 in advanced germ cells with Stra8-GFPCre disrupts spermiogenesis, whereas mice with single deletion of either Mettl3 or Mettl14 in advanced germ cells show normal spermatogenesis. The spermatids from double-mutant mice exhibit impaired translation of haploid-specific genes that are essential for spermiogenesis PMID: 28914256
3. SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells. PMID: 27606421
4. SOHLH1 and SOHLH2 were able to directly and cooperatively repress STRA8 expression in cell lines in vitro through binding to its promoter. PMID: 25603532
5. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function PMID: 25102060
6. periodic RA-STRA8 signaling intersects with periodic germ-cell competencies to regulate two distinct, cell-type-specific responses: spermatogonial differentiation and meiotic initiation PMID: 25902548
7. Our findings suggest that the mTOR signaling pathway may have role in the proliferation and stimulation of meiotic initiation of spermatogonial stem cells PMID: 25241363
8. CYP26B1 suppresses two distinct genetic programs induced by retinoic acid: a Stra8-dependent meiotic pathway, and a Stra8-independent mitotic pathway. PMID: 24576537
9. cultured XX and XY germ cells at 11.5 and 12.5 days postcoitus (dpc) with an RA receptor inhibitor. Expression of Stra8, a meiosis initiation gene, was suppressed in all groups PMID: 22262692
10. Stra8-deficient mice had an 88% decrease in teratoma incidence, providing direct evidence that premature initiation of the meiotic program contributes to tumorigenesis. PMID: 22438569
11. DMRT1 controls Stra8 sex-specifically, activating it in the fetal ovary and repressing it in the adult testis. PMID: 21621532
12. Stra8 and Dazl are highly expressed in premeiotic germ cells that do not undergo further differentiation in aged mouse ovaries. PMID: 20157580
13. In this study, a detailed analysis of the EGFP expression pattern in the testis was carried out, showing that the transgene was expressed in meiotic and postmeiotic germ cells and not in undifferentiated germ cells. PMID: 19378319
14. Endogenous Stra8 gene expression is higher in differentiating spermatogonia than in undifferentiated spermatogonia and could mediate the RA effects on spermatogonial maturation. PMID: 18032419
15. STRA8 protein expression in adult spermatogonia was induced by RA stimulation, suggesting its role in spermatogonial differentiation. PMID: 18322276
16. In both the male and female germ lines, meiosis is initiated through retinoic acid induction of Stra8. PMID: 18799751
17. STRA8 is involved in the process that leads to stable commitment to the meiotic cell cycle. PMID: 18799790
18. STRA8 associates with DNA and possesses transcriptional activity. PMID: 19805549

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KEGG: mmu:20899

STRING: 10090.ENSMUSP00000031876

UniGene: Mm.5171