Recombinant Mouse T-box brain protein 1 (Tbr1)

1. Study induced neuronal differentiation of mouse bone mesenchymal stem cells (bMSCs) into neuron-like cells in vitro. miR-122-5p was well complementary with the target site of Tbr1 mRNA3'UTR and could inhibit Tbr1 expression by binding to its 3'UTR. Expressions of Tbr1 mRNA and protein were decreased. Overexpression of miR-122-5p downregulated the expressions of Tbr1, NSE, and TAU. PMID: 28240720
2. CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal. PMID: 28234597
3. Mice lacking Tbr1 have Ca2+ waves in the cortex at normal frequencies and with normal neurotransmitter dependencies. PMID: 26473411
4. Our findings highlight a TBR1-regulated network of autism spectrum disorders genes in the developing neocortex that are relatively intolerant to loss-of-function mutations, indicating that these genes may play critical roles in normal cortical development. PMID: 27325115
5. T-Brain-1 (TBR1), a causative gene in autism spectrum disorders (ASDs), encodes a brain-specific T-box transcription factor. PMID: 25600067
6. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice PMID: 25981743
7. Transgenic overexpression of Wnt7b decreased expression of Tbr1 in both progenitor cells and post-mitotic neurons. PMID: 24953933
8. This study demonistrated that Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. PMID: 24441682
9. Results show that the expression of Tbr1 in neural stem and progenitor cells prevents them from following an astrocyte fate during olfactory bulb development. PMID: 20807572
10. TBR1 is a direct transcriptional repressor of Fezf2 and a negative regulator of CS tract formation that restricts the laminar origin of CS axons specifically to L5. PMID: 21285371
11. TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 and CTIP2. PMID: 21228164
12. Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons. PMID: 20615956
13. Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex PMID: 20348416
14. While Tbr1 is expressed in postmitotic neurons, Tbr2 (which is also expressed during gastrulation) is also expressed in neural progenitors. PMID: 12128215
15. We suggest that Tbr-1/CASK protein complex regulates expression of these downstream target genes and thus modulates neuronal activity and function. PMID: 15584924
16. These findings delineate the transcription factor sequence Pax6 --> Tbr2 --> Tbr1 in the differentiation of radial glia --> intermediate progenitor cell --> postmitotic projection neuron. PMID: 15634788
17. Here, we provide a tool to illuminate a unique subset of SP and deep CP neurons: expression of a Tbrain-1 (Tbr1)-driven transgene. PMID: 16188453
18. Tbr1 gene is expressed in cells that interact with olfactory sensory neurons PMID: 17506891
19. Taken together, our data illustrate that Ngn2, neuroD and Tbr transcription factors are involved in postnatal neurogenesis in the olfactory bulb. PMID: 19200230

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KEGG: mmu:21375

STRING: 10090.ENSMUSP00000046787

UniGene: Mm.308525