Recombinant Mouse Taste receptor type 1 member 2 (Tas1r2), partial

1. our platform provides in depth analysis of new sweeteners either alone or in competition and/or inhibition studies to fully understand the structure/functional role of ATD region of T1R2 that transpires in the initial binding event prior to sweet taste response. PMID: 30282936
2. Data suggest that Tas1r2 and Tas1r3 are involved in regulation of Glp1 secretion in enteroendocrine cells; 3DG (3-deoxyglucosone) attenuates high glucose-stimulated Glp1 secretion by antagonizing Tas1r2/Tas1r3 subunits and downstream cAMP signaling. (Tas1r2 = sweet taste receptor subunit Tas1r2; Tas1r3 = sweet taste receptor subunit Tas1r3; Glp1 = glucagon-like peptide-1) PMID: 29277113
3. Data, including data from studies with mutant and knockout mice, suggest that Tas1R3 and Tas1R2 are expressed endogenously in osteoclast stem cells; their expression levels parallel robust increase in osteoclast biomarker Ctsk during osteoclast differentiation. (Ctsk = cathepsin K) PMID: 29019082
4. mice lacking T1R2 + T1R3 and controls were tested in a taste discrimination task to determine whether maltodextrins are 1) detectable when both receptor subunits are absent and 2) perceptually distinct from that of sucrose. Some KO mice were only sensitive to the higher Polycose concentrations, implicating potential allelic variation in the putative polysaccharide receptor pathways unmasked by the absence of T1R2+T1R3. PMID: 28768658
5. results implicate each subunit of the T1R2+T1R3 dimer in the behavioral response to P-containing taste compounds PMID: 28383662
6. T1R2 plays an important role in glucose homeostasis during diet-induced obesity through the regulation of yet to be identified molecular mechanisms that alter energy disposal and utilization in peripheral tissues. T1r2 was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance. PMID: 26884387
7. Mice possess two taste transduction pathways for sugars. One mediates behavioral attraction to sugars and requires an intact T1r2+T1r3. The other mediates cephalic phase insulin release but does not require an intact T1r2+T1r3. PMID: 26157055
8. human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3 PMID: 25029362
9. T1R2 and T1R3 knockout mice have increased cortical bone mass and trabecular remodeling. PMID: 24466105
10. effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3 PMID: 24068707
11. T1R2+3 heterodimer is the principal receptor that mediates taste detection of natural sweeteners, but not of all carbohydrate stimuli. PMID: 22621968
12. Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion in vitro and in vivo. PMID: 22315413
13. the present study provides behavioral evidence for the presence of a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer. PMID: 21940444
14. These results demonstrate the expression of bitter taste receptors of the T2R family in the mouse and rat gastrointestinal tract PMID: 11854532
15. behavioral and physiological characterization of T1R1, T1R2, and T1R3 knockout mice PMID: 14636554
16. analysis of heterodimeric models of the T1R2-T1R3 receptor PMID: 15738209
17. In the present study, we compared the genomic organization of rodent T2R genes based on the recently completed mouse and rat genomes and examined tissue- and cell-specific expression of T2Rs. PMID: 15886333
18. Each of the two subunits in the heteromeric T1R2:T1R3 sweet taste receptor binds sweet stimuli though with distinct affinities and conformational changes. PMID: 16271873
19. T2Rs may regulate GI function via release of regulatory peptides and activation of the vagal reflex pathway. PMID: 18003792
20. Activation of the mGlu7 receptor produces anxiolytic-like effects via the modulation of the gamma-aminobutyric acid system. PMID: 18690114
21. T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: implications for saccharide taste receptors in mice. PMID: 19158407

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KEGG: mmu:83770

STRING: 10090.ENSMUSP00000030510

UniGene: Mm.190612