Recombinant Mouse Thioredoxin-dependent peroxide reductase, mitochondrial (Prdx3)

1. The importance of mitochondrial Prdx3 in regulating the oxidative stress environment in adipocytes.Loss of Prdx3 leads to decreased pS473 Akt and insulin-stimulated glucose transport. PMID: 28986255
2. Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. PMID: 26797130
3. This study showed that from E10.5,Prdx3 showed strong ventral lateral expression. This increased ventral immunotaining persisted until E18.5 but became relatively less striking at later stages. PMID: 25975898
4. Prx3 plays a crucial role in mitochondrial homeostasis and thereby controls the contractile functions of skeletal muscle. PMID: 25224038
5. The SirT1 regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase, catalase, peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2, and uncoupling protein 2. PMID: 23461683
6. Prx3 is up-regulated in response to oxidative stress; the maintenance of Prx3 levels in hair cells is a critical factor in their susceptibility to acquired hearing loss. PMID: 23626763
7. The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. PMID: 22490042
8. PrxIII in mouse adrenal cortex is inactivated by H(2)O(2) produced by cytochrome P450 enzymes during corticosterone production stimulated by adrenocorticotropic hormone. PMID: 22681886
9. endogenous Prx3 may play an essential role in maintaining normal characteristics of adipocytes and that defect in Prx3 alters mitochondrial redox state and function. PMID: 21902452
10. Immunohistochemical analysis revealed segment-specific alterations induced by the ischemic insult. Grx2, Prx3, and Prx6 were highly expressed in proximal tubule cells PMID: 21586322
11. Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. PMID: 20929858
12. Results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists. PMID: 20716930
13. This study showed that peroxiredoxin 3 protects pancreatic beta cells from cell stress induced by accumulation of hydrogen peroxide, or the induction of inducible nitric oxide synthase or caspase-9 and -3 by pro-inflammatory cytokines or streptozotocin. PMID: 20807727
14. Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals, suggesting that, in the absence of a sufficient amount of Srx PMID: 19086807
15. PRDX3 is a c-Myc target gene that is required to maintain normal mitochondrial function. c-Myc directly activates expression of a mitochondrial peroxiredoxin that is required for Myc-mediated transformation. PMID: 12011429
16. mitochondrial Prdx3 is an important cellular antioxidant that regulates physiological levels of H(2)O(2) PMID: 12861054
17. Roles of MER5 function for the oxidative stress responses by intratracheal inoculation of lipopolysaccharide (LPS) to the mice were examined. PMID: 17316558
18. Expression of 40 proteins, including the antioxidative enzymes peroxiredoxin 1 and 3, glutathione peroxidase 1, and SOD-1, was increased with diabetes, suggesting an adaptive response to oxidative stress associated with this diabetic model. PMID: 17609286
19. significantly increased following 200 microM mono-(2-ethylhexyl) phthalate treatment PMID: 18077825
20. Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of Prx VI, but not Prx II or Prx III in the heart PMID: 18426799
21. Increased oxidative stress in placentas that were deficient in PrxIII. PMID: 18544346
22. PrxIII is necessary for macrophages to protect against lipopolysaccharide-induced oxidative stress. PMID: 19155266
23. Local antioxidant activity of peroxiredoxin 3 may have a role in maintaining cardiac function. PMID: 19230834

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KEGG: mmu:11757

STRING: 10090.ENSMUSP00000025961

UniGene: Mm.29821