Recombinant Mouse Toll-like receptor 2 (Tlr2), partial

Code CSB-YP023601MO
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Source Yeast
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Code CSB-EP023601MO
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Source E.coli
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Code CSB-EP023601MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP023601MO
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Source Baculovirus
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Code CSB-MP023601MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Tlr2
Uniprot No.
Alternative Names
Tlr2; Toll-like receptor 2; EC 3.2.2.6; CD antigen CD282
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides. Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling. Acts as the major receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR1 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. Recombinant MPT83 from M.tuberculosis stimulates secretion of cytokines (TNF-alpha, IL-6 and IL-12p40) by mouse macrophage cell lines in a TLR2-dependent fashion, which leads to increased host innate immunity responses against the bacterium. Lung macrophages which express low levels of TLR2 respond poorly to stimulation by M.tuberculosis LpqH. Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM. Interacts with TICAM2.
Gene References into Functions
  1. The expression of TLR2 and MUC2 in HT-29 cells was up-regulated in stimulation with the exosomes of Gymnophalloides seoi. PMID: 30019213
  2. These findings further validated the involvement of P. acnes in the pathology of intervertebral disc degeneration (IVDD) and provided evidence that P. acnes-induced apoptosis of NPCs via the TLR2/JNK pathway is likely responsible for the pathology of IVDD PMID: 29323102
  3. TLR2 expression in placenta is up-regulated during maternal murine cytomegalovirus infection. PMID: 30128872
  4. Osteoclastogenesis was accelerated by activation of TLRs through upregulation of Lox-1 expression during bone marrow cell (BMC) differentiation into bone marrow macrophages (BMMs), suggesting dyslipidemia increases the risk of periodontitis. PMID: 29859535
  5. These results indicated an important role for B7-H3 in the development of Th1 and Th2 cells in a murine model of asthma and its proinflammatory effects are not dependent on TLR2 signaling. PMID: 28094276
  6. TLR2 and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1beta in diabetic mice. IL-1beta causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity. PMID: 27882934
  7. Dendritic cell expression of TLR2 is essential for optimal Th1 immune response against pneumococci in mice immunized with Streptococcus pneumoniae DnaJ-DeltaA146Ply. PMID: 29229733
  8. These findings suggest that, in the adipose tissue of obese mice, TLR2 is involved in the metabolism of collagen I and may exhibit a role in the metabolism of MMP1, TIMP1 and TGFbeta1. PMID: 29436650
  9. NOD2 could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression. PMID: 29913461
  10. In the initial periods of AP progression, an increased expression of MMP9 in the TLR2 KO and MyD88 KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 expression in the TLR2 KO mice were observed. MMP2 and MMP9 production was modulated for TLR2 and MyD88 during apical periodontitis progression PMID: 29267523
  11. The results unmask an important role of TLR2 in the development of sickness behaviors via stimulation of hypothalamic microglia to promote proopiomelanocortin neuronal activation in association with hypothalamic inflammation. PMID: 27405276
  12. Feeding Guar gum fiber increases SOCS-1, TLR2 and dectin-1 expression in dextran sodium sulfate administered and normal mice. PMID: 28608623
  13. Our findings suggested the collaboration of TLR2-TLR9 at least in the regulation of SARM expression. PMID: 28889202
  14. results indicate that although live B. anthracis and S. aureus express abundant TLR2 ligands, highly-purified PGN from either bacterial source is not recognized by TLR2. PMID: 29474374
  15. these results support that PIP5Kalpha can positively mediate TLR2-associated immune responses through Phosphatidylinositol 4,5-bisphosphate production in microglial cells. PMID: 28711717
  16. heme released to the brain parenchyma after intracerebral hemorrhage injury activates TLR2 in astrocytes and induces inflammatory gene expression and blood-brain barrier damage. PMID: 28646881
  17. TLR2 modulates Staphylococcus aureus-induced inflammatory response and autophagy in macrophages through PI3K signaling pathway. PMID: 29089069
  18. Results demonstrate that TLR2 signal plays an important role in the regulation of iNOS expression after C. sinensis infection. TLR2 signal is also beneficial to limiting worm growth and development and contributing to the susceptibility to C. sinensis in which the iNOS/NO reactions possibly participate. PMID: 28784165
  19. IL-33 production induced by P. gingivalis fimbriae and lipopeptide is recognized by TLR2 and may modulate dendritic cel function in periodontal diseases. PMID: 28637954
  20. TLR2 confers a pivotal role in allergic airway inflammation via regulating the PI3K/Akt signaling pathway-related autophagy in mice. PMID: 28493079
  21. findings strongly suggest that TLR2 participates in mycobacteria-induced innate immune responses in pleural mesothelial cells. PMID: 28249177
  22. Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation. PMID: 27554518
  23. Data suggest that continued toll-like receptor 2 activation contributes to the developing neuroinflammation and pathology and may be provide a strategy for limiting the progression of Alzheimer's disease. PMID: 27422717
  24. results suggest that the TLR2-p38-CD86 signaling pathway plays a vital role in inflammation associated with burn injury PMID: 28460187
  25. Isoflurane relieves zymosan-induced neutrophil inflammatory lung response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling pathway. PMID: 27144523
  26. Results of RNA-sequencing demonstrated roles for TLR2 varied by cell type during T. gondii infection. Our findings facilitate understanding of the detailed relationship between TLR2 and T. gondii infection, and elucidate mechanisms underlying neurological changes during infection PMID: 29136637
  27. TLR2 expression on B1a cells is not critical for their IgM-dependent atheroprotection. PMID: 27930350
  28. our results demonstrate that 5-HT induces the invasion of commensal E. coli into gut submucosa by amplifying commensal bacteria-induced epithelial signaling (superoxide production and the inductions of NOX2 and TLR2/TLR4). The authors suggest that these changes may constitute the molecular basis for the pathogenesis of inflammatory bowel disease (IBD). PMID: 28216386
  29. TLR2 signaling could be involved in the increase in the B-1 cell population induced by Propionibacterium acnes. PMID: 27233619
  30. Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections PMID: 27805901
  31. we conclude that coordinate engagement of NOD2 and TLR2 constitutes a key step in the genesis of Lp-mediated protection from a lethal respiratory virus infection, and represents a critical target for modulation of virus-induced inflammatory pathology. PMID: 27312104
  32. Toll-like receptor 2 (TLR2) and retinoic acid-inducible gene I (RIG-I) cooperatively initiate innate immune responses to MuV infection in mouse ovarian granulosa cells. PMID: 27477784
  33. Mycobacterium tuberculosis protein Rv3529c suppresses TLR2-mediated proinflammatory responses in macrophages. PMID: 28877954
  34. During the late stage of middle ear infection, the absence of TLR2 can lead to reduced macrophage recruitment, impaired pneumococcal clearance, and prolonged inflammation. Our results demonstrate that TLR2 signaling is critical for bacterial clearance and timely resolution of inflammation in otitis media induced by pneumococcus. PMID: 27463737
  35. a role for TLR2 in controlling cutaneous leishmaniasis disease severity has been demonstrated in vivo; absence of this phenotype in either TLR1-/- or TLR6-/- mice suggests that TLR2 does not have a specific requirement for either known co-receptor during Leishmania infection; findings indicate that parasite lipophosphoglycan is not required for the observed TLR2 mediated effects PMID: 27716391
  36. these results reveal a novel role of T-cell expressed TLR2 in enhancing the differentiation and function of TH9 T cells PMID: 28665005
  37. TLR2 plays a key role in platelet hyperreactivity and the prothrombotic state in the setting of hyperlipidemia by sensing a wide range of endogenous lipid peroxidation ligands and activating innate immune signaling cascade in platelets. PMID: 28775078
  38. The present results indicate that the lack of TLR2 does affect the nerve regeneration process in sciatic nerve disease. PMID: 27222120
  39. These data illustrate a functional role for TLR2 in the pathogenesis of choroidal neovascularization. PMID: 28739342
  40. This study reveals the striking ability of a prototypical innate immune receptor to trigger a potent and suppressive IL-10 response in effector/memory T cells, supporting the notion that TLR2 is a co-regulatory receptor on T cells. PMID: 28742882
  41. Dual TLR2/TLR7 agonist induced the maturation of dendritic cells and primed substantial populations of cytolytic and highly polyfunctional effector CD8(+) T cells in vitro, and safely potentiated the immunogenic properties of a nanoparticulate Ag in vivo, eliciting humoral responses with a balanced TH1/TH2 profile in mice. PMID: 28432147
  42. In conclusion, the authors demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response. PMID: 28164040
  43. The results indicate that the disease-preventing effects of Bacteroides fragilis in acute dextran sulfate sodium-induced colitis may occur through the TLR2/IL-10 signal pathway. PMID: 28683149
  44. Silencing of TLR2 by siRNA substantially down-regulated MG-triggered autophagy in macrophages. PMID: 28478286
  45. we demonstrated for the first time that the cross-talk of TLR2 and TLR9 triggered Th1 activation collaboratively PMID: 27693915
  46. IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta responses in a TLR2- and FcgammaR-dependent fashion. PMID: 27365531
  47. a specific TLR2-mediated mechanism of central nervous system inflammation and leukocyte invasion into the neonatal brain, is reported. PMID: 27493242
  48. TLR2 signaling contributes to superficial erosion in the vascular endothelium and local blood flow disturbance. PMID: 28428204
  49. TLR2 is essential for an efficient immune response against Streptococcus pneumonia meningitis. PMID: 27725130
  50. TLR2 activation requires IRAK-M/IRAK-2 to induce TNF-alpha-associated adverse changes in the myocardium under stressful conditions. PMID: 28432060

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft.
Protein Families
Toll-like receptor family
Tissue Specificity
Detected in a macrophage cell line, smooth muscle, lung, spleen, thymus, brain and adipose tissue. Cell surface expression detected in lung alveolar macrophages, dendritic macrophages and at lower levels in lung macrophages (at protein level).
Database Links
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