Recombinant Mouse Transcription factor 7 (Tcf7)

1. Naive CD8+ T Cell TCF7 expression is FOXO1 independent. PMID: 28973925
2. the inhibition of beta-catenin's TCF-dependent transcriptional activity, independent of its protein expression level, retains the naive ground state pluripotency in mouse embryonic stem cells. PMID: 28577307
3. The balance between CD4(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (encoding TCF-1) and by the expression of the inhibitory receptors PD-1 and LAG3. PMID: 27806296
4. data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8(+) and CD4(+) T cell responses to viral infection PMID: 28652395
5. Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury. PMID: 26642437
6. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells. PMID: 25536344
7. The data suggest that miR-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 expression in osteoblastic cells. PMID: 26006243
8. this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage PMID: 26324778
9. Our results support a critical role for miR-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis. PMID: 26193896
10. TCF-1 was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 promoted Bcl-6 expression but repressed Blimp1 expression. PMID: 26214740
11. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. PMID: 23932570
12. Our data support that the loss of Tcf7 diminishes hematopoietic stem cell function. PMID: 23212152
13. TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes. PMID: 23660861
14. These results are reminiscent of the critical roles of TCF-1 in early T cell development. PMID: 23601684
15. The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin. PMID: 22550000
16. TCF-1-deficient (Tcf7(-/-)) mice developed aggressive T cell malignancy. PMID: 23103132
17. TCF-1 and lymphoid enhancer-binding factor (LEF)-1 are essential for generation of memory precursors and functional memory CD8+ T cells. PMID: 22875805
18. Together with RUNX1, TCF7 regulates a network of transcription factors that characterize the CD34+ cell state. PMID: 22412390
19. TCF1 and beta-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus. PMID: 22492686
20. The TCF-1-mediated repression of IL-17 is critical for peripheral T cells to generate balanced immune responses. PMID: 21935461
21. Tcf-1 is shown to be a gatekeeper of T-cell fate and Tcf-1 is directly activated by Notch signals. PMID: 22109558
22. our data demonstrated that TCF-1 enhances CD4(+)CD8(+) double-positive thymocyte survival through transcriptional upregulation of RORgammat PMID: 22039299
23. showed that TCF-1 deficiency limited proliferation of CD8(+) effector T cells and impaired their differentiation toward a central memory phenotype PMID: 20727791
24. show that mice lacking T cell factor 1 (Tcf-1), a nuclear effector of the canonical Wingless/Integration 1 (Wnt) signaling pathway, mount normal effector and effector memory CD8 T cell responses to infection with lymphocytic choriomeningitis virus. PMID: 20457902
25. Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. PMID: 12731066
26. A role of the constitutive activation of beta-catenin/Tcf signaling in skin carcinogenesis is discussed. PMID: 15765534
27. cyclooxygenase-2/PGE2 may exert pro-oncogenic actions through stimulating the beta-catenin/T cell factor-mediated transcription, which plays critical roles in colorectal carcinogenesis PMID: 15899904
28. TCF/beta-catenin pathway enhances CD4 expression in vivo by recruiting TCF-1 to stimulate CD4 enhancer activity. PMID: 16585583
29. vascular endothelial growth factor expression is induced through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells PMID: 17008323
30. pro-osteogenic action of beta-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity PMID: 18247340
31. Data demonstrate marked changes in gene expression after Wnt3a stimulus, and show that NIH3T3 fibroblasts expressing a fusion protein of beta-catenin and TCF7 resulted in the identification of 92 genes as putative TCF targets. PMID: 19563800
32. TCF-1 initiates T(H)2 differentiation of activated CD4(+) T cells by promoting GATA-3 expression and suppressing IFN-gamma expression. PMID: 19648923

Show More

Hide All

KEGG: mmu:21414

STRING: 10090.ENSMUSP00000084055

UniGene: Mm.31630