Recombinant Mouse Transcription factor GATA-6 (Gata6)

1. The long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. A number of angiogenesis- and hypoxia-related genes were downregulated by GATA6-AS silencing. Silencing of GATA6-AS diminishes TGF-beta2-induced endothelial-mesenchymal transition in vitro and promotes formation of blood vessels in mice. PMID: 29339785
2. Gata6 could be utilized as a biomarker to select the best Pluripotent stem cell (PSC) lines to produce PSC-derived cardiomyocytes. PMID: 29335067
3. Phosphorylation of GATA6 by Erk1/2 compels exit from pluripotent state, and the phosphorylation propels a GATA6 positive feedback regulatory circuit to compel primitive endoderm differentiation PMID: 29454706
4. These findings identify Gata6-directed differentiation of neural crest to vascular smooth muscle cells as an essential mechanism that specifies the aortic tree, and provide a new framework for how mutations in GATA6 lead to congenital heart disorders in humans. PMID: 28952437
5. Data (including data from studies in knockout mice and transgenic mice) suggest that pancreatic islets in adult mice deficient in GATA6 activity exhibit decreased insulin content and impaired insulin secretion. Gata6-deficient mice are apparently normal at birth; as they age they develop glucose intolerance. PMID: 29263149
6. results support a model in which Gata6 contributes to repression of Isl1 expression in the anterior of nascent hindlimb buds. PMID: 29197504
7. During wound healing differentiated Gata6(+) cells migrate from the sebaceous duct into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue. PMID: 28504705
8. The authors find that Gata6 protects against DNA damage associated with proliferation, thus preventing cell cycle arrest and apoptosis. PMID: 27908934
9. Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3, and Dax1 inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells. PMID: 27601327
10. In the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways. PMID: 25596178
11. Our results, for the first time, portray a pivotal role of GATA6 in regulating metastatic behaviors of breast cancer cells PMID: 26505174
12. data indicated that GATA-6 and Akt2 are involved in the mTORC1-mediated regulation of VSMC proliferation and differentiation. PMID: 25969542
13. GATA6 contributes to the development and postnatal function of the murine atrioventricular node by promoting cell-cycle exit of specified cardiomyocytes toward a conduction system lineage. PMID: 25613430
14. Gata6 is a versatile and potent reprograming factor that can act alone to drive a cell fate switch from diverse cell types PMID: 26109048
15. Mice with double deletion of Gata4 and Gata6 lack identifiable adrenal glands. Inactivation of Gata6 alone drastically reduced the adrenal size and corticosterone production in the adult animals. PMID: 25933105
16. These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling. PMID: 25015078
17. In KRAS-mutant mice, nicotine promotes pancreatic carcinogenesis and tumor development via down-regulation of Gata6 to induce acinar cell dedifferentiation. PMID: 25127677
18. In the absence of Gata6, all inner-cell-mass cells adopt an epiblast identity. PMID: 25209243
19. Gata6 is expressed in proximal airway epithelium throughout lung development. PMID: 24970044
20. Gata6 regulates differentiation, metabolism, and survival of resident peritoneal macrophages through aspartoacylase. PMID: 25024137
21. GATA6 creates an environment permissive for CRC initiation by lowering the threshold of BMP signalling required for tumour stem cell expansion PMID: 24952462
22. Gata6 mutants exhibit a complete absence of primitive endoderm and GATA6 levels regulate the timing and speed of lineage commitment within the inner cell mass. PMID: 24835466
23. Study identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. PMID: 24792964
24. Piceatannol inhibits the development of cardiac hypertrophy through regulation of the expression and activity of transcriptional factor GATA6. PMID: 24662306
25. conditional loss of Shh in limb buds lacking GATA6 prevents development of hindlimb polydactyly in these compound mutant embryos. PMID: 24415953
26. Selective deficiency of Gata6 in myeloid cells caused substantial alterations in the transcriptome of peritoneal macrophages. Gata6 deficiency also resulted in dysregulated peritoneal macrophage proliferative renewal during homeostasis and in response to inflammation, which was associated with delays in the resolution of inflammation. PMID: 24762537
27. Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. PMID: 23002247
28. GATA6 regulates the differentiation of steroidogenic progenitors into adrenocortical cells. PMID: 23471215
29. GATA6 and FOXA2 bind the Wnt6 promoter and regulate its activity, leading to primitive endoderm formation. PMID: 22607194
30. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). PMID: 23275439
31. Loss of Gata6 in the pancreas caused mild pancreatic defects. Loss of both Gata4 & Gata6 caused pancreatic agenesis, disrupted progenitor cell proliferation, disturbed branching morphogenesis, & failed to induce CPA1+/NEUROG3+ progenitor cells. PMID: 23006325
32. Double Gata4/Gata6 mutants failed to develop pancreata, died shortly after birth, & displayed hyperglycemia. Loss of only 1 Gata6 allele on a Gata4 conditional knockout background severely reduced pancreatic mass. PMID: 23006330
33. In the colon, Gata6 deletion resulted in shorter, wider crypts, a decrease in proliferation, and a delayed crypt-to-surface epithelial migration rate. PMID: 22733991
34. These results demonstrate that GATA-4 and GATA-6 are needed for normal ovarian function. PMID: 22434075
35. Post-transcriptional repression of Gata6 expression by Unr contributes to the stabilization of the embryonic stem cells pluripotent state. PMID: 21954113
36. Reveal a previously uncharacterized phenotypic heterogeneity in the myocardium and suggest that decreased gap junctional coupling leads to induction of a signaling pathway that utilizes a unique GATA6 enhancer. PMID: 21908788
37. Muc5b is a target gene of transcription factors (TTF-1, GATA-6) involved in lung differentiation programs during development and carcinogenesis. TTF-1 is a strong repressor of Muc5b. PMID: 21126317
38. The results suggest that GATA6 is downstream of Grb2 in the inductive signaling pathway and the expression of GATA6 is sufficient to compensate for the defects caused by Grb2 deficiency in the development of the primitive and extraembryonic endoderm. PMID: 20925113
39. GATA6 plays a crucial role for endothelial cell function and survival, at least in part, by suppressing autocrine TGFbeta expression and ALK5-dependent signaling. PMID: 21127043
40. Results suggest that alterations in gene expression of Gata6, Tspan8, S100a8, and Lmo2 may act via novel pathways that play functionally important roles in Men1-associated tumor progression. PMID: 20531244
41. GATA-6 is both necessary and sufficient for regulating the cardiac hypertrophic response and differentiated gene expression, both alone and in coordination with GATA-4 PMID: 20705924
42. Wnt2 works in a feedforward transcriptional loop with Gata6 to regulate posterior cardiac development. PMID: 20159597
43. role in regulating WNT7b promoter PMID: 11914369
44. GATA6 regulates differentiation of distal lung epithelium. PMID: 11959831
45. GATA-6 can act as a positive or negative regulator of smooth muscle-specific gene expression PMID: 15550397
46. GATA-6 regulates a set of genes associated with vascular smooth muscle synthetic functions. GATA-6 regulates multiple genes involved in cell-cell signaling & cell-matrix interactions, as well as endothelin-1 & the AT1a receptor genes. PMID: 15591218
47. GATA6 alone is available for liver bud growth and commitment of the endoderm to a hepatic cell fate PMID: 15767668
48. GATA-6 is required to sense morphogenic (retinoic acid) signal; collaboration between GATA-6 and GATA-4, or GATA-6 and GATA-5 is involved in the perception of differentiation cues by embryonic stem cells in their determination of endoderm lineage PMID: 16162334
49. Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium. PMID: 16199866
50. Data show that Hop is expressed in airway epithelium coincident with HDAC2, and acts downstream of Nkx2.1 and GATA6, to negatively regulate surfactant protein expression. PMID: 16510470

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KEGG: mmu:14465

STRING: 10090.ENSMUSP00000041774

UniGene: Mm.329287