Recombinant Mouse Urokinase plasminogen activator surface receptor (Plaur), partial

1. The results establish GDE3 as a negative regulator of the uPAR signaling network and, furthermore, highlight GPI-anchor hydrolysis as a cell-intrinsic mechanism to alter cell behavior. PMID: 28849762
2. The ratio of full-length versus cleaved uPAR as analysed by Western blotting and its regulation was assessed by addition of different protease inhibitors and transforming growth factor - beta1 (TGF-beta1). The role of uPAR cleavage in cell proliferation and migration was analysed using real-time cell analysis and invasion was assessed using the myoma invasion model PMID: 28526008
3. Plg-RKT is required for plasminogen binding and macrophage migration in vivo PMID: 27714956
4. Results identify soluble uPAR as a functional connection between the bone marrow and the kidney, and they implicate bone marrow immature myeloid cells as a key source of soluble uPAR that leads to glomerular dysfunction. PMID: 27941791
5. Plaur deficiency does not increase susceptibility to epileptogenesis after traumatic brain injury in an animal model. PMID: 27208924
6. Findings indicate a significant correlation of uPAR cleavage with breast cancer progression, but the precise biological consequence(s) of the cleavage or the cleavage products still remains to be elucidated. PMID: 25809119
7. interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR. PMID: 26380915
8. In an in vivo murine angiogenesis model uPAR-deficient PTEN heterozygous animals increased the impaired angiogenic phenotype of uPAR knockout mice and were able to reverse the high invasive potential of PTEN heterozygotes. PMID: 25925849
9. uPAR contributes to macrophage driven atherosclerotic lesion formation. PMID: 26313756
10. our data show that uPAR is required for efficient skin tumor formation PMID: 26527290
11. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. PMID: 25157856
12. deficiency of uPAR and PSMD6 delays DNA repair and leads to decreased cell survival. PMID: 24987841
13. uPA promotes remodeling of the fracture cartilage by osteoclasts that are associated with angiogenesis and suggest that uPA promotes angiogenesis and remodeling of the fracture cartilage at this time of bone fracture repair. PMID: 23700285
14. Binding of urokinase to uPAR promotes the reorganization of the actin cytoskeleton and re-emergence of dendritic filopodia after excitotoxic injury. PMID: 25339736
15. Inactivation of urokinase-type plasminogen activator receptor gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice. PMID: 23852693
16. High uPAR expression is associated with glioma. PMID: 22495828
17. A deficiency in uPAR represents a mechanisms which results in the development of a more severe epilepsy phenotype. PMID: 23263886
18. sLR11 regulates the hypoxia-enhanced adhesion of HSPCs via an uPAR-mediated pathway that stabilizes the hematological pool size by controlling cell attachment to the BM niche. PMID: 23486467
19. Importance of vitronectin and its interaction with the urokinase receptor in tumor growth. PMID: 23327926
20. uPAR silencing by uPAR knockout in mouse VSMC resulted in abrogation of doxorubicin-induced cellular senescence. PMID: 23172421
21. our studies indicated that uPAR plays a significant role in ovarian cancer PMID: 22577342
22. uPAR is dispensable for nerve development, whereas, loss of uPAR affects nerve regeneration. PMID: 22363796
23. pulmonary and systemic inflammation induced by TLR2, but not TLR4 stimulation is reduced in uPAR-/- mice PMID: 21998707
24. Nuclear uPAR associates with myocardin, which is then recruited from the promoters of serum response factor target genes and undergoes proteasomal degradation. This mechanism contributes to adverse vascular remodeling after injury in vivo. PMID: 22075245
25. NYD-SP8 has a role in regulating ECM degradation, providing a novel mechanism that modulates urokinase signalling in the suppression of cancer progression PMID: 19017363
26. uPAR might guide/control the trafficking of mesenchymal stem cells to the injured vascular wall and their differentiation towards functional smooth muscle cells. PMID: 21088115
27. Results suggest that uPAR plays a pivotal role in the development of adipose tissue through PI3K/Akt pathway. PMID: 20886176
28. Downregulation of uPAR reduced the radiation-induced tumor cell adhesion, migration and invasion by inhibiting phosphorylation of FAK. PMID: 20886051
29. uPAR overexpression induced stem cell-like properties and an increase in breast tumor initiation and growth. PMID: 20940399
30. The plasminogen system is critical for liver repair by facilitating macrophage accumulation and triggering a cascade of subsequent repair events. PMID: 20345714
31. fibrin loss from microarteriolar thrombi is mediated, at least in part, by leukocyte-associated uPA in a process that requires leukocyte uPAR and PSGL-1 PMID: 19967153
32. uPAR is necessary for adequate recruitment of neutrophils into the alveoli and lungs during pneumonia caused by Streptococcus pneumoniae, a pathogen eliciting a beta 2 integrin-independent inflammatory response. PMID: 11907112
33. Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT. PMID: 11959893
34. essential role in acute inflammation as well as in chronic degenerative vascular processes such as atherosclerosis PMID: 12023845
35. MMP-12 and other MMPs directly and efficiently cleave uPAR at the Thr86 paralal Tyr87 peptide bond located in the linker region connecting uPAR domains 1 and 2, releasing the major ligand binding domain 1 from the rest of the receptor. PMID: 12195704
36. Knockout causes disruption of cortical interneuron development, region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction PMID: 12533622
37. This protein, along with the associated protein, is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. PMID: 12668656
38. uPAR deficiency suppresses renal macrophage recruitment, but its absence accentuates the fibrogenic response, likely due in part to the delayed clearance of angiogenic/profibrotic molecules such as PAI-1 and decreased receptor-associated uPA activity. PMID: 12707393
39. uPAR attenuates the fibrogenic response to renal injury, an outcome that is mediated in part by urokinase-dependent but plasminogen-independent functions. PMID: 12707394
40. REVIEW of roles in regulation of diverse physiological and pathological processes, including cellular adhesion, cell motility, angiogenesis, tumor invasion, and tumor metastasis. PMID: 12828301
41. Data report the identification of novel promoter regions required for expression of the urokinase-type plasminogen activator receptor in transgenic mice. PMID: 12875967
42. signaling for the uPAR response, as mediated by B. burgdorferi, proceeds with CD14 and TLR2 as partial contributors PMID: 14500474
43. Protein C inhibitor may contribute to proteolysis equilibrium within the testis by acting in tandem with urokinase in Leydig cells and with PC and/or urokinase in spermatogenic cells. PMID: 14645112
44. The u-PAR plays an important role in the proliferative response of VSMCs and that without u-PAR, there is no intracellular signaling for cell proliferation. PMID: 15081564
45. uPAR seems to play a pivotal role in VEGFR-2-induced endothelial cell migration. PMID: 15131009
46. uPA transgenic mice have chalky-white incisors and, when uPAR is co-expressed, develop extensive alopecia, epidermal thickening, and subepidermal blisters. PMID: 15161662
47. Enhanced proliferation of uPAR-/- fibroblasts seems to be mediated by uPA-dependent ERK signaling via an alternative urokinase receptor. PMID: 15284295
48. Domain 2 of the urokinase receptor plays a pivotal role in the regulation of uPAR-integrin alphavbeta3 interactions PMID: 15863511
49. uPAR function is necessary for the development of a subpopulation of GABAergic neurons in the telencephalon. It is likely that the late-onset parvalbumin phenotype is due to the effects of an altered local environment on selectively vulnerable neurons. PMID: 16025458
50. Loss of urokinase-type plasminogen activator is associated with inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis PMID: 16049338

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KEGG: mmu:18793

STRING: 10090.ENSMUSP00000002284

UniGene: Mm.1359