Recombinant Mouse V (D)J recombination-activating protein 2

1. the zinc finger motif within the noncore region of RAG2 is indispensable for maintaining the stability of the RAG2 protein. PMID: 26692406
2. evolution of RAG1/RAG2 began with a Transib transposon whose intrinsic recombination activity was enhanced by capture of an ancestral RAG2, allowing for the development of adaptive immunity. PMID: 27056670
3. Rag2(R229Q) knock-in mice developed an inflammatory bowel disease affecting both the small bowel and colon. PMID: 26926994
4. Rag2 truncation substantially increased the frequency of off-target V(D)J recombination. The data suggest that interactions between Rag2 and a specific chromatin modification, H3K4me3, support V(D)J recombination fidelity. PMID: 26365182
5. These results reveal an unanticipated functional interplay between the RAG complex and XLF in repairing RAG-induced DNA breaks and maintaining genome integrity during antigen receptor gene assembly. PMID: 26833222
6. This study demonstrated that The behavioral impairments in Rag2(-/-) mice were paralleled by an elevation in plasma corticosterone after behavioral tests. PMID: 25257108
7. V(D)J recombination is stimulated by binding of H3K4me3 to RAG-2 PMID: 25543141
8. Rag2-/-Il1rn-/- mice develop spontaneous severe colitis with high mortality. PMID: 24770649
9. Both the RAG2 C-terminus and ATM prevent bi-locus RAG-mediated cleavage through modulation of three-dimensional conformation (higher-order loops) and nuclear organization of the two loci. PMID: 23900513
10. Humanized Rag2 -/- gammac -/- mice produce the major target cells of HIV-1 and these cells can be detected in primary and secondary lymphoid tissues, as well as in the vaginal and rectal mucosa and brain tissues PMID: 23824904
11. Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. PMID: 24052573
12. Data show that recombination activating gene-2 (Rag2), is required for toll-like receptor 9 (TLR9)-mediated induction of interferon-alpha (IFNalpha) in bone marrow-derived dendritic cells (pDCs). PMID: 23110142
13. Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells PMID: 22984564
14. USF-1 but not USF-2 is strongly enriched at Dbeta2 in chromatin from either Rag2-/- (deficient) thymocytes or Rag2-/- thymocytes that express a rearranged Tcrb transgene. PMID: 22287717
15. Using recombination activation gene-2-deficient (RAG-2(-/-)) blastocysts and embryonic stem cells with homozygous NFI-A gene deletion, we show an essential role for NFI-A in T-cell activation. PMID: 21602176
16. hSIRPa-transgenic Rag2(-/-)gamma(c)(-/-) mice represent a unique mouse strain supporting high levels of human cell engraftment. PMID: 21788509
17. results reveal a novel genome guardian role for RAG2 and suggest that similar 'end release/end persistence' mechanisms underlie genomic instability and lymphomagenesis in Rag2(c/c) p53(-/-) and Atm(-/-) mice PMID: 21368836
18. Careful analysis of the Rag2 intergenic region uncovered a second evolutionarily conserved Nwc promoter region from which a previously unknown Nwc transcript can be generated in nonlymphocytes of Nwctmpro1 and normal mice. PMID: 21243488
19. Rag2-deficient mice given Ccr6(null)CD4(positive)CD45RB(high-expressing) T cells had more severe colitis with increased interferon (IFN) gamma-producing T cells, compared with the mice given wild-type cells. PMID: 20720211
20. Rag2 knockout mice were not able to clear up influenza A virus infection. PMID: 20667098
21. Impaired B cell receptor (BCR) editing and a serum B cell activating factor (BAFF) abundance might contribute toward the development of a pathogenic B cell repertoire in hypomorphic Rag2(R229Q) knock-in mice. PMID: 20547828
22. These findings unambiguously demonstrate postthymic, RAG-dependent TCR rearrangement and define TCR revision as a tolerance pathway that targets mature peripheral CD4(+) T cells. PMID: 20435935
23. The tissue- and stage-specific expression of RAG-2 is regulated by alteration of the chromatin structure as well as cis-regulatory enhancer elements during lymphocyte ontogeny. PMID: 12097391
24. generates mature T-and B-cells PMID: 12100900
25. Rag2 interacts with both wt and mutant RAG1 proteins equally well and forms RAG1-RAG2-RSS complexes. PMID: 12154124
26. unresolved RAG-2 mediated breaks during V(D)J recombination trigger a nonreciprocal replication pathway (i.e., break-induced-replication), leading to the juxtaposition of IgH and c-myc loci. PMID: 12186839
27. molecular mechanism of the rapid cytoplasmic sequestration/degradation of the RAG2 protein PMID: 12205088
28. effect of Rag2 gene transfer to rag2-/- mice on t-cell and b-cell reconstitution and function PMID: 12393742
29. RAG-dependent peripheral TCR diversification occurs in T8-cells. When antigen-specificT8 cells from NOD mice were stimulated by dendritic cells, daughter cells reexpressed RAGs, stopped making antigen-specific TCRs, & made a vast array of other TCRs.. PMID: 12432095
30. the RAG2 C terminus has potential roles in mediating rearrangement of endogenous antigen-receptor loci PMID: 12531919
31. intrinsic RAG-2 NLS functions in the nuclear uptake of RAG-2 following its reexpression in cycling cells PMID: 12861017
32. Deficiency is required to induce pathologic immune responses against the islet self-antigens. PMID: 15210748
33. Injection of CD34+ cells into newborn Rag2(-/-) mice conferred resistance to gamma-irradiation. PMID: 15319293
34. the effect of HMGA1 on RAG2 expression is direct; identification of the responsible region in the RAG2 promoter and demonstration of binding to the promoter in vivo using chromatin immunoprecipitation PMID: 15713121
35. A transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled T cell acute lymphoblastic leukemia. PMID: 15827121
36. PHD finger, a zinc finger, is a novel and functionally important domain of RAG2. PMID: 15964836
37. Purified RAG2 protein from thymocytes of young mice associates with endogenous histone in a manner that is dependent on the RAG2 carboxyl terminus PMID: 16111638
38. should be valuable to study virus-induced pathology and to rapidly evaluate new approaches aiming to prevent or treat HIV infection PMID: 17038503
39. A knockin murine model carrying the Rag2 R229Q mutation previously described in several patients with Omenn syndrome (OS)supports the notion that impaired immune tolerance and defective immune regulation are involved in the pathophysiology of OS. PMID: 17476358
40. RAG2(-/-) mice demonstrated fatigue with shorter inverted hang-times (HT) and voluntary wheel-running (VWR) distance and total run times; they increased body weight more slowly but had proportionally normal forelimb grip strength (FGS) and VWR speed. PMID: 17554799
41. The crystal structures of the RAG2 plant homeodomain alone & complexed with 5 modified H3 peptides show that this one domain simultaneously recognizes 2 distinct histone modifications, permitting complex read-out of combinatorial histone modifications. PMID: 18025461
42. The high-resolution crystal structure of the mouse RAG2 PHD finger bound to H3K4me3 reveals the molecular basis of H3K4me3-recognition by RAG2. PMID: 18033247
43. Endoplasmic reticulum stress plays an important role in cell death and cardiac dysfunction in beta(1)-extracellular loop (EC)(II) IgG cardiomyopathy, and the effects of beta(1)-EC(II) IgG are mediated via the beta(1)-adrenergic receptor. PMID: 18155231
44. These results indicate that accessibility of NWC promoter and RAG promoters to trans-acting factors is regulated by different epigenetic mechanisms. PMID: 18166226
45. The effect of the enterohepatic bacterial pathogen Helicobacter hepaticus on liver and intestine tumorigenesis in BALB-RagMin mice is reported. PMID: 18411292
46. In mice lacking the non-core domain of RAG2 the ordered rearrangement is disturbed and direct V to D rearrangements are 10- to 1000-times increased in tri-partite immune gene loci. PMID: 18776220
47. humanized mice showed low levels of human engraftment in the intestinal tract and seem to be resistant to rectal transmission of HIV PMID: 18842716
48. These results reveal different strategies of Epstein-Barr virus infection in B cells that possibly result from variations in the host immune response. PMID: 18845836
49. In scid mice, the frequency of Rag2-mediated rearrangements was relatively low compared with that in wild-type mice, suggesting that the Rag2-independent lymphoma pathway prevails in the development of thymic lymphomas in scid mice. PMID: 19000702
50. These results confirm essential roles for inflammation, increased TNF-alpha expression, and elevated nitric oxide production in colon carcinogenesis. PMID: 19164562

Show More

Hide All

KEGG: mmu:19374

STRING: 10090.ENSMUSP00000038204

UniGene: Mm.4988