Recombinant Mouse Voltage-dependent L-type calcium channel subunit alpha-1C (Cacna1c), partial

1. miR-137 regulated the expression of the CACNA1C gene. PMID: 30102687
2. The Shank3/F model, and to a much lesser extent, the Shank3/J and Cacna1c models, showed hypoactivity and a general anxiety-like behavior triggered by external stimuli which pervaded social interactions. PMID: 28753255
3. Proteolytic cleavage and phosphorylation of alpha1C subunit are not required for adrenergic regulation of CaV1.2 in the heart. PMID: 28784807
4. The data of this study illustrated an important role of CaV1.2 in fear extinction and the synaptic regulation of activity within the amygdala. PMID: 29038219
5. Cav1.2 mutation associated with Timothy syndrome has pleiotropic effects on the ascending serotonin system. PMID: 28921675
6. Cardiac specific expression of the mutated Cav1.2PKA_P2(-/-) gene reduces Cav1.2 alpha1c protein concentration, calcium current (ICa), and the beta-adrenergic stimulation of L-type ICa in cardiomyocytes. PMID: 28778765
7. the significant decrease or absence of exon 33-containing CaV1.2 channels is potentially proarrhythmic in the heart. PMID: 28490495
8. Findings suggest that REDD1 in cacna1c heterozygous mice may influence depression-related behavior via regulation of the FoxO3a pathway. Study identified the prefrontal cortex as a key brain region in which cacna1c mechanisms through previously unidentified, novel molecular pathways contribute to depression-related behavior. PMID: 27922594
9. Normal regulation of CaV1.2 channels by phosphorylation of Ser1700 in cardiomyocytes is required for cardiovascular homeostasis and normal physiological regulation in vivo. PMID: 27864509
10. Cacna1c reduction causally predisposes to the maladaptive outcomes of social stress. PMID: 28165117
11. Deletion of psychiatric risk gene Cacna1c impairs hippocampal neurogenesis PMID: 28230278
12. A novel and selective role was found for the Cav1.2 channel in the hippocampus that mediates extinction of cocaine conditioned place preference. PMID: 29089442
13. Findings indicate tissue-specific differences in L-type calcium channel CaV1.2 regulation and suggest that it may be possible to design therapies to target this channel in specific tissues. PMID: 28119457
14. Data indicate a subpopulation of the CaV1.2 channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes. PMID: 28119464
15. S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Cav1.2 and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade. PMID: 28119465
16. Cav1.2 can modulate oligodendrocyte maturation in the demyelinated brain and is critical for remyelination. PMID: 28899915
17. CaV1.2 knock-out mice exhibited normal acquisition and recall of the location of the hidden platform in a standard Morris water maze, but were unable to form a memory of when the number of available spatial cues was restricted. Within the dentate gyrus, pan-neuronal deletion of CaV1.2 resulted in decreased cell proliferation and the numbers of doublecortin-positive adult-born neurons. PMID: 27957527
18. The present study shows that ANO1 and CavL play a central role in the generation of slow waves, phasic contractions and tone in the internal anal sphincter and that this pathway can occur in the absence of stretch PMID: 28054347
19. Cacna1c haploinsufficient mice lack normal sensitivity to inhibition of the dopamine transporter. Cacna1c is crucial for normal behavioral responses to DA stimulants. PMID: 28186690
20. Data (including data from studies using transgenic/knockout mice) suggest Cacna1c is involved in specific aspects of learning (behavioral strategies for increasing reward rate); majority of Cacna1c knockout mice manage to increase reward feedback across trials but appear to do so by adapting outcome-based behavioral strategy, while majority of control mice appear to adopt experimentally intended cue-association behavior. PMID: 28604818
21. This study showed that Cav1.2, but not Cav1.3, L-type calcium channel subtype mediates nicotine-induced conditioned place preference in mice. PMID: 28185965
22. We report that the protein densin-180 is highly enriched at excitatory synapses in the brain and enhances the cell surface trafficking and postsynaptic localization of Cav1.2 L-type Ca(2+) channels in neurons. This interaction promotes coupling of Cav1.2 channels to activity-dependent gene transcription. PMID: 28363979
23. These results indicate that Cav1.2 modulates oligodendrocyte development and suggest that Ca(2+) influx mediated by L-type voltage-operated Ca(2+) channels inoligodendrocyte progenitor cells is necessary for normal myelination PMID: 27798140
24. The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 upon beta-adrenergic stimulation rendering Cav1.2 refractory for several minutes from further beta-adrenergic stimulation. PMID: 27103070
25. findings suggest that Hap1 is important for insulin secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2, providing new insight into the mechanisms that regulate insulin release from pancreatic beta-cells. PMID: 27624941
26. these data indicate for the first time a functional interaction between Orai1, TRPC1, and CaV1.2 channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2+) entry due to co-activation of Orai1- and TRPC1-dependent store-operated Ca(2+) channels and L-type Ca(2+) channels. PMID: 27535226
27. These findings suggest that Trpc3 is a mediator of pathologic cardiac hypertrophy not only through mediating part of the Ca(2+) influx, but also through control of CaV1.2 expressions. PMID: 27522668
28. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. PMID: 27247394
29. This study demonstrate a role of Cav1.2 in regulating survival of young hippocampal neurons in living mice by studying both forebrain-Cav1.2 cKO mice. PMID: 27066530
30. Results provide evidence that decreased Cacna1c expression has a protective role in the modulation of age-related cognitive declines, and support an interaction between Cacna1c, sex and memory impairment PMID: 25989111
31. Both the extracellular PFXYD motif and the transmembrane domain of PLM but not the cytoplasmic tail were necessary for regulation of peak L-type Ca(2+) current amplitude. PMID: 25918050
32. Treatment of MSC with BMP4 caused a significant increase in expression of Cav1.2, a delay in expression of Cav1.1, and a reduction in the duration of calcium transients when extracellular calcium was removed PMID: 25277766
33. data suggest that miR-103 inhibits osteoblast proliferation mainly through suppression of Cav1.2 expression under simulated microgravity condition PMID: 25868801
34. The down-regulation of Cav1.2 expression and the inhibition of LTCCs caused by mechanical unloading in osteoblasts are partially due to miR-103 up-regulation. PMID: 25627864
35. Ammonium-induced deregulation of astroglial Ca(2+) signalling, is, in part, associated with upregulation of Cav1.2 L-type calcium channels PMID: 25846713
36. Methamphetamine alters DNA methylation, expression, and protein abundance of CACNA1C. PMID: 26307267
37. demonstrate for the first time that both Cav1.2 and Cav1.3 are necessary for neuronal survival but are differentially required for the biophysical properties of neurons PMID: 26242732
38. Our findings reveal that the intra-SR protein Casq2 is largely responsible for the phenomenon of SR Ca(2+) release refractoriness in murine ventricular myocytes. PMID: 25758429
39. results suggest the involvement of Cacna1c (Cav1.2) in fast electroencephalogram oscillations and REM sleep regulatory processes PMID: 25845695
40. Cp8 is a new of Cav1.2 and Cav1.3 channel activators. PMID: 24941892
41. alpha1C L-type calcium channel protein levels were significantly lower in PC-1 knockout hearts. PMID: 25888683
42. The expression of Cav1.2 mRNA was rhythmic and was regulated by the circadian clock component REV-ERBalpha. PMID: 25238857
43. Activation of both Cav1.2 and Cav1.3 can support burst firing of dopaminergic VTA neurons. PMID: 24848473
44. Cav1.2 knockdown induced a decrease in the proportion of oligodendrocytes that express myelin proteins. PMID: 25542980
45. These data demonstrate that type 1 diabetic serum hyperactivates both CaV1.2 and CaV1.3 channels by increasing their conductivity and number. PMID: 25292336
46. Phosphorylation at Ser-1700 alone is essential to maintain basal Ca(2+) current and regulation by beta-adrenergic activation. Mutant mice develop cardiac hypertrophy. PMID: 25368181
47. the alpha1C PDZ motif is not required for surface trafficking, localization to the dyad, or adrenergic stimulation of CaV1.2 in adult cardiomyocytes PMID: 25505241
48. Cav1.3 was significantly upregulated in many brain areas 24hr after a single nicotine injection, whereas Cav1.2 expression was not significantly altered at this timepoint PMID: 24470632
49. mRNA expression in neonatal ventricular myocytes PMID: 24936064
50. Loss of Cav1.2 is associated with cystic kidney. PMID: 24925129

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KEGG: mmu:12288

UniGene: Mm.41628