Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-1 (Cacna2d1), partial

1. Cacna2d1 regulated the intraocular pressure and glaucoma susceptibility. PMID: 29176626
2. Study identified a critical role for alpha2delta-1 in freeze-lesion-induced developmental cortical malformation pathologies and in mediating the neuroprotective effects of gabapentin (GBP). Genetic deletion of alpha2delta-1 did not eliminate GBP's effects on synaptogenesis, suggesting that GBP can have alpha2delta-1-independent effects. PMID: 29109971
3. Results show that overexpression of alpha2delta-1 alone in TG mice can enhance excitatory connectivity in neocortex and lead to neural circuit hyperexcitability and episodes of electrographic epileptiform activity, associated with behavioral arrests in transgenic mice. PMID: 28193459
4. Loss of the Ca(2+) channel alpha2delta-1 subunit function increases the susceptibility for developing diabetes in a sex-dependent manner. PMID: 28115397
5. Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 may contribute to individual differences in von Frey filament response. PMID: 27231153
6. a TSP4/Cavalpha2delta1-dependent pathway activated by TSP4 or peripheral nerve injury promotes exaggerated presynaptic excitatory input and evoked sensory neuron hyperexcitability and excitatory synaptogenesis. PMID: 27129212
7. Our findings support a role of peripheral nerve injury-induced alpha2delta1 in enhancing pre-synaptic excitatory PMID: 24151064
8. These results suggest calcium channel-independent effects of alpha2delta-1 on feeding and implicate alpha2delta-1-thrombospondin interactions known to facilitate excitatory synapse assembly PMID: 24403154
9. These findings suggest that the alpha(2)delta(4) subunit participates in the modulation of L-type Ca(2+) current regulating neurotransmitter release from photoreceptor terminals PMID: 23296739
10. alpha2delta-1 is essential for rapid development of mechanical hypersensitivity in a nerve injury model of neuropathic pain. PMID: 24133248
11. Expression of Cacna2d1 is enhanced in the amygdala in a model of innate anxiety. PMID: 22849384
12. This study of the rabbit ortholog of dihydropyridine-sensitive calcium channel alpha 2 provides N-terminal sequencing evidence of the cleavage junction of the alpha2 and delta subunits from the preprotein PMID: 1847144
13. This study demonistrated that Cacna2d1 gene expression in mouse dorsal raphe nucleus PMID: 22534482
14. The alpha(2) delta(1) subunit, previously described as an L-type auxiliary subunit, complexes with the T-type Ca(v)3.2 (alpha(1H)) subunit in MLO-Y4 cells. PMID: 21638318
15. Upregulation of alpha(2)/delta subunit of VGCC in the frontal cortex and the limbic forebrain plays a critical role in development of morphine-induced rewarding effect and behavioral sensitization following neuronal plasticity. PMID: 19596051
16. alpha(2)-delta Type 1 subunit of voltage-gated calcium channels is the major binding protein for pregabalin in the brain and spinal cord. PMID: 16460711
17. These results indicate that BZDs examined here have the potential to increase L-type HVCC functions mediated via the enhanced expression of alpha2/delta1 subunit after their sustained exposure. PMID: 17949410
18. The calcium channel alpha2/delta1 subunit in skeletal muscle plays a role in extracellular signalling. The alpha2/delta1 subunit may be crucial for muscle development, muscle repair, and myoblast attachment and migration. PMID: 18063658
19. mechanism of Cavalpha2delta1-mediated spinal sensitization in which elevated Cavalpha2delta1 causes increased pre-synaptic glutamate release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli. PMID: 19216737

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KEGG: mmu:12293

STRING: 10090.ENSMUSP00000049457

UniGene: Mm.159842