Recombinant Mouse Zinc-alpha-2-glycoprotein (Azgp1)

Code CSB-YP720705MO
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP720705MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP720705MO
MSDS
Size Pls inquire
Source Baculovirus
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Azgp1
Uniprot No.
Alternative Names
Azgp1; Zinc-alpha-2-glycoprotein; Zn-alpha-2-GP; Zn-alpha-2-glycoprotein
Species
Mus musculus (Mouse)
Expression Region
18-307
Target Protein Sequence
QET GSYYLTFLYT GLSRPSKGFP RFQATAFLND QAFFHYNSNS GKAEPVGPWS QVEGMEDWEK ESQLQRAREE IFLVTLKDIM DYYKDTTGSH TFQGMFGCEI TNNRSSGAVW RYAYDGEDFI EFNKEIPAWI PLDPAAANTK LKWEAEKVYV QRAKAYLEEE CPEMLKRYLN YSRSHLDRID PPTVTITSRV IPGGNRIFKC LAYGFYPQRI SLHWNKANKK LAFEPERGVF PNGNGTYLSW AEVEVSPQDI DPFFCLIDHR GFSQSLSVQW DRTRKVKDEN NVVAQPQ
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.
Gene References into Functions
  1. ZAG may be beneficial for preventing high-fat-diet-induced hepatic lipid metabolic disorders. PMID: 28934818
  2. Zinc alpha2 glycoprotein promotes browning in adipocytes. PMID: 29317208
  3. AZGP1 is a negative regulator of fibrosis progression in kidney and heart PMID: 25788525
  4. thyroid hormone up-regulates the production of zinc-alpha2-glycoprotein in the liver but not in the adipose tissue. PMID: 24465683
  5. Overproduction of ZAG in white adipose tissue in chronic kidney disease could be a major contributor to metabolic disturbances associated with CKD. PMID: 23423258
  6. Fatty acid synthase and hormone-sensitive lipase expression in liver are involved in zinc-alpha2-glycoprotein-induced body fat loss in obese mice. PMID: 21180279
  7. ZAG synthesis in adipose tissue and the liver is downregulated, as are its circulating levels, in ob/ob mice. PMID: 19934249
  8. Azgp1 is a possible candidate gene for regulation of body weight, elucidation of polygenic inheritance, and age-dependent changes in the genetic control of obesity. PMID: 12882938
  9. Mice bearing the MAC16-tumor displayed substantial losses of body weight and fat mass, which was accompanied by major increases in ZAG mRNA and protein. PMID: 14983038
  10. Glucocorticoids stimulate lipolysis through an increase in azgo1 expression, and they are responsible for the increase in azgp1 expression seen in adipose tissue of cachectic mice. PMID: 15714206
  11. results suggest that EPA may preserve adipose tissue in cachectic mice by downregulation of ZAG expression through interference with glucocorticoid signalling PMID: 15899583
  12. ZAG deficiency correlated with a significant decrease in adipocytic lipolysis PMID: 17234189

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Subcellular Location
Secreted.
Protein Families
MHC class I family
Database Links
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