Recombinant Mouse Zinc-alpha-2-glycoprotein (Azgp1)

In Stock
Code CSB-MP720705MO
Abbreviation Recombinant Mouse Azgp1 protein
MSDS
Size $318
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity
Greater than 95% as determined by SDS-PAGE.
Activity
Not Test
Target Names
Azgp1
Uniprot No.
Research Area
Others
Alternative Names
Zn-alpha-2-GP; Zn-alpha-2-glycoprotein
Species
Mus musculus (Mouse)
Source
Mammalian cell
Expression Region
18-307aa
Target Protein Sequence
QETGSYYLTFLYTGLSRPSKGFPRFQATAFLNDQAFFHYNSNSGKAEPVGPWSQVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYKDTTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPEMLKRYLNYSRSHLDRIDPPTVTITSRVIPGGNRIFKCLAYGFYPQRISLHWNKANKKLAFEPERGVFPNGNGTYLSWAEVEVSPQDIDPFFCLIDHRGFSQSLSVQWDRTRKVKDENNVVAQPQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Mol. Weight
35.1 kDa
Protein Length
Full Length of Mature Protein
Tag Info
C-terminal 10xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.
Gene References into Functions
  1. ZAG may be beneficial for preventing high-fat-diet-induced hepatic lipid metabolic disorders. PMID: 28934818
  2. Zinc alpha2 glycoprotein promotes browning in adipocytes. PMID: 29317208
  3. AZGP1 is a negative regulator of fibrosis progression in kidney and heart PMID: 25788525
  4. thyroid hormone up-regulates the production of zinc-alpha2-glycoprotein in the liver but not in the adipose tissue. PMID: 24465683
  5. Overproduction of ZAG in white adipose tissue in chronic kidney disease could be a major contributor to metabolic disturbances associated with CKD. PMID: 23423258
  6. Fatty acid synthase and hormone-sensitive lipase expression in liver are involved in zinc-alpha2-glycoprotein-induced body fat loss in obese mice. PMID: 21180279
  7. ZAG synthesis in adipose tissue and the liver is downregulated, as are its circulating levels, in ob/ob mice. PMID: 19934249
  8. Azgp1 is a possible candidate gene for regulation of body weight, elucidation of polygenic inheritance, and age-dependent changes in the genetic control of obesity. PMID: 12882938
  9. Mice bearing the MAC16-tumor displayed substantial losses of body weight and fat mass, which was accompanied by major increases in ZAG mRNA and protein. PMID: 14983038
  10. Glucocorticoids stimulate lipolysis through an increase in azgo1 expression, and they are responsible for the increase in azgp1 expression seen in adipose tissue of cachectic mice. PMID: 15714206
  11. results suggest that EPA may preserve adipose tissue in cachectic mice by downregulation of ZAG expression through interference with glucocorticoid signalling PMID: 15899583
  12. ZAG deficiency correlated with a significant decrease in adipocytic lipolysis PMID: 17234189

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Subcellular Location
Secreted.
Protein Families
MHC class I family
Database Links
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