Recombinant Protein maternal effect lethal 26 (mel-26)

Code CSB-YP856698CXY
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP856698CXY
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP856698CXY-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP856698CXY
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP856698CXY
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
mel-26
Uniprot No.
Alternative Names
mel-26; ZK858.4Protein maternal effect lethal 26
Species
Caenorhabditis elegans
Expression Region
1-395
Target Protein Sequence
MEPRIDGGVF IGGIGNSGNE MCSNGVPALG VSSQTEIKVE KVQHTWTVKN FSHCYQEYLE NFVYLQRGDE QLTWSIKIYP KGNGENNKDF VFLCLNRVIN NNVKAGKIGF KSQFKLRTAE NKDIEMRIHP NPSHSDYVSY IKRDVLFPQI MPRDMIIVNV EIDVAVETIT TTNEPIQFEP TNSEQQLIED YQRLFSQELL CDFAINVNGK IIRAHKAVLA ARSPVFNAML THQDTDEAKS SMMYINDMDY DVIYEMVYYI YCGRCNKDIT DMATALLIAA DKYRLEELKS HCEKYLVENI NIENACSLLI IGDLYSAPKL RKRAVTYILA RPKNVTGTPG WEDILKGHPN LITDIFSQID RQSSTGATSS VSNLPGVPMD IPGITGNIVP PPSGL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway.
Gene References into Functions
  1. KLHL22 plays a conserved role to mediate the activation of mTORC1 and downstream events in mammals and nematodes; depletion of MEL-26, the Caenorhabditis elegans orthologue of KLHL22, extends worm lifespan PMID: 29769719
  2. the identification of a large family of BTB-domain protein MEL-26 and its genetic target MEI-1 as substrate-specific adaptors for C. elegans CUL-3 PMID: 13679922
  3. MEL-26 not only acts as a substrate-specific adaptor within the MEL-26/CUL-3 complex, but also promotes cytokinesis by a CUL-3- and microtubule-independent mechanism. PMID: 16169482
  4. KO8F11.3 regulates mel-26 in the helminth embryo. PMID: 17403899
  5. FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis. PMID: 17878235

Show More

Hide All

Subcellular Location
Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, I band.
Tissue Specificity
Expressed in body wall muscles.
Database Links

STRING: 6239.ZK858.4

UniGene: Cel.5086

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2025 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1